Abstract
Mutation, cell death and chromosome damage are the ultimate products of the response of mammalian cells to DNA-damaging agents. It is important to determine how cells respond to a continuous exposure to DNA damage (much like we experience in our environment) and to learn about the genetic and molecular events that lie between the incurrence of DNA damage and the final appearance of damaged chromosomes and dead or mutated cells. We now know that bacteria induce specific sets of genes in response to certain types of genetic damage;1 evidence that eukaryotes employ similar strategies is rapidly accumulating. Among other things a detailed understanding of these mechanisms will provide a more sound scientific basis upon which to assess the risk to man from DNA-damaging agents in our environment.
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© 1986 Plenum Press, New York
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Samson, L. (1986). The Adaptive Response of Mammalian Cells to Alkylating Agents. In: Simic, M.G., Grossman, L., Upton, A.C., Bergtold, D.S. (eds) Mechanisms of DNA Damage and Repair. Basic Life Sciences, vol 189. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9462-8_35
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DOI: https://doi.org/10.1007/978-1-4615-9462-8_35
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