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DNA-Protein Cross-Links: New Insights into their Formation and Repair in Irradiated Mammalian Cells

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Mechanisms of DNA Damage and Repair

Part of the book series: Basic Life Sciences ((BLSC,volume 189))

Abstract

The production of strong binding between DNA and protein by radiations and chemicals has been known for many years. DNA-protein cross-links (DPCs) were first recognized as a distinct lesion in ultraviolet light (UV)-irradiated bacteria by Smith1 and by Alexander and Moroson.2 The importance of DPCs for cellular lethality was clearly demonstrated in E. coli.3 Smith has reviewed various aspects of this work on several occasions.4–6

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Authors and Affiliations

  1. Division of Biochemical Oncology, Department of Radiology, Case Western Reserve University, Cleveland, OH, 44106, USA

    Nancy L. Oleinick, Song-mao Chiu, Libby R. Friedman, Liang-yan Xue & Narayani Ramakrishnan

Authors
  1. Nancy L. Oleinick
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  2. Song-mao Chiu
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  3. Libby R. Friedman
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  4. Liang-yan Xue
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  5. Narayani Ramakrishnan
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Editor information

Editors and Affiliations

  1. National Bureau of Standards, Gaithersburg, Maryland, USA

    Michael G. Simic

  2. Chemistry Department, American University, Washington, D.C., USA

    Michael G. Simic

  3. Johns Hopkins University, Baltimore, Maryland, USA

    Lawrence Grossman

  4. New York University Medical Center, New York, New York, USA

    Arthur C. Upton

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© 1986 Plenum Press, New York

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Oleinick, N.L., Chiu, Sm., Friedman, L.R., Xue, Ly., Ramakrishnan, N. (1986). DNA-Protein Cross-Links: New Insights into their Formation and Repair in Irradiated Mammalian Cells. In: Simic, M.G., Grossman, L., Upton, A.C., Bergtold, D.S. (eds) Mechanisms of DNA Damage and Repair. Basic Life Sciences, vol 189. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9462-8_19

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  • DOI: https://doi.org/10.1007/978-1-4615-9462-8_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9464-2

  • Online ISBN: 978-1-4615-9462-8

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