Abstract
Mammalian neuraminidases have been localised inside the lysosomes, in the cytosol as well as in the various membranes of the cell cytocavitary system (1). Brain tissue is especially rich in membrane-bound neuraminidase which reaches its highest specific activity in the plasma membranes isolated from synaptosomes (2, 3). This enzyme cleaves terminal N-acylneuraminic acid residues, predominantly from oligosialogangliosides, thereby degrading them to monosialogangliosides (4–5).
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Abbreviations
- Des-GM1 :
-
(monosialo-gangliotetraitol): Galßl→3GalNAcßl→4Ga1[3←2αNeuAc]ß1→4[3H]sorbitol
- Des-GD1a :
-
(disialo-gangliotetraitol): Gal [3←2αNeuAc] ß1→3GalNAcß 1→4Gal (3←2αNeuAc)ß1→4[3H]sorbitol
- GA2 :
-
Gangliotriaosylceramide (GgOse3Cer): Ga1NACß1→4Galß1→4Glc1→l’ceramide
- GM1 :
-
(ganglioside II3 NeuAc GgOse4-Cer): Galßl→3GaiNACß1→4Ga1[3←2αNeuAc]ß1→4G1cß1→1’ceramide
- GM2 :
-
(ganglioside II3 NeuAc-GgOse3-Cer): Ga1NAcß1→4Gal [3←2αNeuAc]ß1→4Glcß1→1’ceramide
- GDIa :
-
(ganglioside IV3 NeuAc, II3 NeuAc-GgOse4-Cer): Gal [3←2αNeuAc]ß1→3GalNAcß1→4Gal [3←2αNeuAc]ß1→4Glcß1→1’ceramide
- NeuAc:
-
N-Acetylneuraminic acid
- Sialyl-lactitol::
-
NeuAcα2→3Ga1ß1→4[3H]sorbitol
References
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© 1978 Plenum Press, New York
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Sandhoff, K., Pallmann, B., Wiegandt, H., Ziegler, W. (1978). Studies on Bovine Brain Membrane-Bound Neuraminidase (Sialidase). In: Gatt, S., Freysz, L., Mandel, P. (eds) Enzymes of Lipid Metabolism. Advances in Experimental Medicine and Biology, vol 101. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9071-2_42
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DOI: https://doi.org/10.1007/978-1-4615-9071-2_42
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