Skip to main content
SpringerLink
Log in

Alcohol Imbibition and Behavior: A Comparative Genetic Approach

  • Chapter
Psychopharmacogenetics

Abstract

Alcoholism is a major and difficult problem in many countries. In those countries from which at least relatively valid statistical figures are available, i.e., the northern and western European countries, Britain, the USA, Canada and Australia, one can estimate that approximately 4–6% of the men and 0.1–1.5% of the women suffer from alcoholism or problems caused by excessive drinking. It is impossible to estimate the exact number of alcoholics, because the occurrence and frequency figures are totally dependent upon how one defines alcoholism.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • ACHTÉ, K., 1958, Korreloituvatko ABO-veriryhmät ja alkoholismi. (In finnish, with german summary). Duodecim. 74: 20.

    Google Scholar 

  • AHTEE, L. & ERIKSSON, K., 1972, 5-hydroxytryptamine and 5-hydroxyindolylacetic acid content in brain of rat strains selected for their alcohol intake. Physiol. Behay. 8: 123.

    Google Scholar 

  • AHTEE, L. & ERIKSSON, K., 1973, Regional distribution of brain 5hydroxytryptamine in rat strains selected for their alcohol intake. Ann. N. Y. Acad. Sci. 215: 126.

    Google Scholar 

  • AHTEE, L. & ERIKSSON, K., 1975, Dopamine and noradrenaline content in the brain of rat strains selected for their alcohol intake. Acta Physiol. Scand. (in press)

    Google Scholar 

  • ÅMARK, C., 1951, A study in alcoholism. ZActa Psychiat. Neurol. Scand. Suppl. 70:256.

    Google Scholar 

  • BADR, F. M. & BADR, R. S., 1975, Induction of dominant lethal mutation in male mice by ethyl alcohol. Nature (London) 253: 134.

    Google Scholar 

  • BENNET, E. L. & HEBERT, M., 1960, Investigation of possible biochemical differences correlatedwith ethanol preference in mice. Univ. Calif. Radiation Lab. Quart. Report No. 3208.

    Google Scholar 

  • BILLINGTON, B. F., 1956, Note on distribution of bloodgroups in bronchiectasis and portal cirrhosis. Australas. Ann. Med. 5: 20.

    Google Scholar 

  • BREWSTER, D. J., 1968, Genetic analysis of ethanol preference in rats selected for emotional reactivity. J. Hered. 59:283.

    Google Scholar 

  • CADOTTE, M., ALLARD, S. & VERDY, M., 1973, Lack of ethanol in vitro on human chromosomes. Ann. Gent. 16: 55.

    Google Scholar 

  • CAMPS, F. E. & DODD, B. E., 1967, Increase in the incidence of non-secretors of ABH blood group substances among alcoholic patients. Brit. Med. J. 1: 30.

    Google Scholar 

  • CAMPS, F. E., DODD, B. E. & LINCOLN, P. J., 1969, Frequencies of secretors and non-secretors of ABH blood group substances among 1000 alcoholic patients. Brit. Med. J. 4:457.

    Google Scholar 

  • CICERO, T. J. & HILL, S. Y., 1970, Ethanol self-selection in rats: A distinction between absolute and 95 per cent ethanol. Physiol. Behay. 5: 689.

    Google Scholar 

  • CICERO, T. J. & MYERS, R. D., 1968, Selection of single ethanol test solution in free-choice studies with animals. Quart. J. Stud. Alc. 29: 446.

    Google Scholar 

  • CICERO, T. J. & SMITHLOFF, B. R., 1973, Alcohol oral self-adminis-tration in rats: Attempts to elicit excessive intake and dependence. In: Alcohol Intoxication and Withdrawal. Ex-perimental Studies. Ed. by M. M. Gross, Plenum Press, New York-London. Advan. Exp. Med. Biol. 35: 213.

    Google Scholar 

  • CRUZ-COKE, R., 1965, Color-blindness and cirrhosis of the liver. Lancet 1: 1131.

    Google Scholar 

  • CRUZ-COKE, R. & VARELA, A., 1965, Color-blindness and alcohol addiction. Lancet 2: 1348.

    Google Scholar 

  • DEITRICH, R. A., 1972, Genetic basis of phenobarbital-induced increase in aldehyde dehydrogenase: Implications for alcohol research. Ann. N. Y. Acad. Sci. 167:73.

    Google Scholar 

  • ELLIS, F. W. & PICK, J. R., 1969, Ethanol-induced withdrawal reactions in Rhesus-monkeys. Pharmacologist 11: 256.

    Google Scholar 

  • ERIKSSON, C. J. P., 1973, Ethanol and acetaldehyde metabolism in rat strains genetcially selected for their ethanol preference Biochem. Pharmacol. 22:2283.

    Google Scholar 

  • ERIKSSON, K., 1968, Genetic selection for voluntary alcohol consumption in the albino rat. Science 159: 739.

    Google Scholar 

  • ERIKSSON, K., 1969, Factors affecting voluntary alcohol consumption in the albino rat. Ann. Zool. Fennici 6: 227.

    Google Scholar 

  • ERIKSSON, K., 1971a, Inheritance of behaviour towards alcohol in normal and motivated choice situations in mice. Ann. Zool. Fennici 8: 400.

    Google Scholar 

  • ERIKSSON, K., 1971b, Rat strains specially selected for their alcohol consumption. Ann. Med. Exp. Biol. Fenn. 49:67.

    Google Scholar 

  • ERIKSSON, K., 1972, Behavioral and physiological differences among rat strains specially selectet for their alcohol consumption. Ann. N. Y. Acad. Sci. 197:32.

    Google Scholar 

  • ERIKSSON, K. & MALMSTRÖM, K. K., 1967, Sex differences in consumption and elimination of alcohol in albino rats. Ann. Med. Exp. Biol. Fenn. 45: 389.

    Google Scholar 

  • ERIKSSON, K. & PIKKARAINEN, P. H., 1968, Differences between the sexes in voluntary alcohol consumption and liver ADH-activity in inbred strains of mice. Metab. Clin. Exp. 17:1037.

    Google Scholar 

  • FALCONER, D. S., 1964, Introduction to quantitative genetics. Oliver & Boyd, Edinburgh, 365.

    Google Scholar 

  • FENNA, D., SCHAEFER, O. & GILBERT, J. A. L., 1971, Ethanol metabolism in various racial groups. Can. Med. Ass. J. 105:472.

    Google Scholar 

  • FIALKOW, P. J., THULINE, H. C. & FENSTER, L. F., 1966, Lack of association between cirrhosis and the common types of color blindness. N. Engl. J. Med. 275: 584.

    Google Scholar 

  • FORSANDER, O. & ERIKSSON, K., 1974, F’drekommer det etnologiska skillnader i alkoholens ämnesomsättningen. (in swedish). Alkoholpolitik 37: 115.

    Google Scholar 

  • FREUND, G., 1969, Alcohol withdrawal syndrome in mice. Arch. Neurol. (Chicago) 21: 315.

    Article  Google Scholar 

  • FREUND, G., 1973, Alcohol, barbiturate and bromide withdrawal syndromes in mice. Ann. N. Y. Acad. Sci. 215:224.

    Google Scholar 

  • FULLER, J. L., 1964, Measurement of alcohol preference in genetic experiments. J. Comp. Physiol. Psychol. 57:85.

    Google Scholar 

  • GOLDSTEIN, D. B., 1972, Relationship of alcohol dose to intensity of withdrawal signs in mice. J. Pharmacol. Exp. Ther. 180:203.

    Google Scholar 

  • GOLDSTEIN, D. B., 1973, Inherited differences in intensity of alcohol withdrawal reactions in mice. Nature (London) 245: 154.

    Google Scholar 

  • GOODWIN, D. W., SCHLUSINGER, F., HERMANSEN, L., GUZE, S. B., WINOKUR, G., 1973, Alcohol problems in adoptees raised apart from alcoholic biological parents. Arch. Gen. Psychiat. 28:238.

    Google Scholar 

  • GORELL, G. J. & THULINE, H. C., 1967, Inheritance of alcoholism. Lancet 1: 274.

    Google Scholar 

  • HIRSCH, J., 1967, Behavior-Genetic analysis. McGraw Hill, New York, 522.

    Google Scholar 

  • JACOBY, M. G., 1967, Alcoholism and color-blindness. Lancet 1: 113.

    Article  Google Scholar 

  • JELLINEK, E. M., 1960, The disease concept of alcoholism. Hillhouse Press, New Haven. 246.

    Google Scholar 

  • JINKS, J. L. & FULKER, D. W., 1970, Comparison of the biometrical genetical, mama, and classical approaches to the analysis of human behaviour. Psychol. Bull. 73: 311.

    Google Scholar 

  • JONSSON, E. & NILSSON, T., 1968, Alkoholkonsumption hos monozygota och dizygota tvillingar. (in swedish). Nord. Hyg. Tidskr. 49: 21.

    Google Scholar 

  • KAIJ, L., 1960, Alcoholism in twins. Studies on the etiology and sequels of abuse of alcohol. Diss., Univ. Lund, Almqvist & Wiksell, Stockholm 144.

    Google Scholar 

  • KAKIHANA, R. & MCCLEARN, G. E., 1963, Development of alcohol preference in BALB/c mice. Nature (London) 199: 511.

    Google Scholar 

  • KELLER, M. & ROSENBERG, S. S., 1971, Alcohol and health. First special report of the U. S. Congress on alcohol and health from the secretary of health, education and welfare. DHEW Publication No. 73–9031, reprinted 1972.

    Google Scholar 

  • LESTER, D., 1966, Self-selection of alcohol by animals, human variation and the etiology of alcoholism. Quart J. Stud. Alc. 27: 395.

    Google Scholar 

  • LIEBER, C. S. & DECARLI, L. M., 1968, Ethanol oxidation by hepatic microsomes: Adaptive increase in ethanol feeding. Science 162:917.

    Google Scholar 

  • LOEHLIN, J. C., 1972, An analysis of alchol related questionnaire items from the national merit twin study. Ann. N. Y. Acad. Sci. 197:117.

    Google Scholar 

  • MARDONES, J., 1960, Experimentally induced changes in the free selection of ethanol. Int. Rev. Neurobiol. 2:41.

    Google Scholar 

  • MARDONES, J. 1972, Evidnece of genetic factors in the appetite for alcohol and alcoholism. Ann. N. Y. Acad. Sci. 197:138.

    Google Scholar 

  • MATHER, K. & JINKS, J. L., 1971, Biometrical genetics, the study of continuous variation. 2ned ed. Chapman Hall, London, 382.

    Google Scholar 

  • MCCLEARN, G. E., 1973, The genetic aspects of alcoholism. In alcoholism, progress in research and treatment. Ed. by P. G. Bourne and R. Fox, Academic Press, New York and London, 337–358.

    Google Scholar 

  • MCCLEARN, G. E. & RODGERS, D. A., 1959, Differences in alcohol preference among inbred strains of mice. Quart J. Stud. Alc. 20: 691.

    Google Scholar 

  • MCCLEARN, G. E. & RODGERS, D. A., 1961, Genetics factors in alcohol preference of laboratory mice. J. Comp. Physiol. Psychol. 54: 116.

    Google Scholar 

  • MURRAY, R. F. & MOTULSKY, A. G., 1971, Developmental variation in the isoenzymes of human liver and gastric alcohol dehydrogenase. Science 171: 71.

    Google Scholar 

  • HYRHED, M., 1974, Alcohol consumption in relation to factors associated with ischemic heart disease. A co-twin control study. Acta Med. Scand. Suppl. 567:93.

    Google Scholar 

  • NORDMO, S. H., 1959, Blood groups in skizopreania, alcoholism and mental deficiency. Amer. J. Psychiat. 116:460.

    Google Scholar 

  • OGATA, S. & MIZOHATA, M., 1972, Studies on atypical human liver dehydrogenase in Japanese. Report of 30th International Congress on Alcoholism and Drug Dependence, Amsterdam.

    Google Scholar 

  • PARTANEN, J., BRUUN, K. & MARKKANEN, T., 1966, Inheritance of drinking behavior. A study on intelligence, personality, and use of alcohol of adult twins. The Finnish Foundation for Alcohol Studies 14: 159.

    Google Scholar 

  • RODGERS, D. A., 1966, Factors underlying differences in alcohol preference among inbred strains of mice. Psychosom. Med. 28: 498.

    Google Scholar 

  • RODGERS, D. A. & MCCLEARN, G. E., 1962, Mouse strain differences in preference for various concentrations of alcohol. Quart. J. Stud. Alc. 23: 26.

    Google Scholar 

  • ROE, A., 1944, The adult adjustment of children of alcohlic parents raised in foster homes. Quart J. Stud. Alc. 5:378.

    Google Scholar 

  • SASSOON, H. F., WISE, J. B. & WATSON, J. A., 1970, Alcoholism and color vision: are there familial links? Lancet 2: 367.

    Google Scholar 

  • SATINDER, K. P. 1972, Behavior-genetic-dependent self-selection of alcohol in rats. J. Comp. Physiol. Psychol. 80:422.

    Google Scholar 

  • SEIXAS, F. A. & EGGLESTON, S., 1973, Alcoholism and the central nervous system. Ann. N. Y. Acad. Sci. 215: 389.

    Google Scholar 

  • SCHLESINGER, K., KAKIHANA, R. & BENNET, E. L., 1966, Effects of tetraethylthiuramdisulfate (Antabuse) on the metabolism and consumption of ethanol in mice. Psychosom. Med. 28:514.

    Google Scholar 

  • SCHUCKIT, M. A., 1972, Family history and halfsibling research in alcoholism. Ann. N. Y. Acad. Sci. 197:121.

    Google Scholar 

  • SHEPPARD, J. R., ALBERSHEIM, P. & MCCLEARN, G. E., 1968, Enzyme activities and ethanol preference in mice. Biochem. Genet. 2: 205.

    Google Scholar 

  • SINCLAIR, J. D., 1974a, Rats learning to work for alcohol. Nature (London) 249: 590.

    Google Scholar 

  • SINCLAIR, J. D., 1974b, Morphine suppresses alcohol drinking regardless of prior alcohol access duration. Pharmacol. Biochem. Behay. 2:409.

    Google Scholar 

  • SINCLAIR, J. D. & SENTER, R. J., 1968, Development of an alcohol-deprivation effect in rats. Quart. J. Stud. Alc. 29: 863.

    Google Scholar 

  • SINCLAIR, J. D., ADKINS, J. WALKER, S., 1973, Morphine induced suppression of alcohol drinking in rats. Nature (London) 246: 425.

    Google Scholar 

  • SMITH, J. W., 1972, Color vision in alcoholics. Ann. N. Y. Acad. Sci. 197:143.

    Google Scholar 

  • SPEISER, P., 1958, Krankheiten und Blutgruppen. Krebsarzt 4: 208.

    Google Scholar 

  • SWINSON, R. P. & MADDEN, J. S., 1973, ABO-bloodgroups and ABHsubstance secretion in alcoholics. Quart J. Stud. Alc. 34: 64.

    Google Scholar 

  • THOMAS, K., 1969, Selection and avoidance of alcohol by two strains of inbred mice and derived generations. Quart, J. Stud. Alc. 30:849.

    Google Scholar 

  • THULINE, H. C., 1972, Considerations in regard to a proposed association of alcoholism and color-blindness. Ann. N. Y. Acad. Sci. 197:148.

    Google Scholar 

  • DE TOROK, D., 1972, Chromosomal irregularities in alcoholics. Ann. N. Y. Acad. Sci. 197:96.

    Google Scholar 

  • WALD, G., 1968, The molecular basis of visual excitation. Nature (London) 219: 800.

    Google Scholar 

  • WALLGREN, H. BARRY, H., III., 1970, Actions of alcohol. Vol. 1, Elsevier, Amsterdam, 400.

    Google Scholar 

  • VAN THIELE, D. H., CAVALER, J. LESTER, R., 1974, Ethanol inhibition of vitamin A metabolism in the testes: Possible mechanism for sterility in alcoholics, Science 186: 941.

    Google Scholar 

  • VARELA, N., RIVERA, L., MARDONES, J. CRUZ-COKE, R., 1969, Color vision defects in non-alcoholic relatives of alcoholic parents. Brit. J. Addict.

    Google Scholar 

  • WARTBURG, J-P. PAPENBERG, J., 1966, Alcohol dehydrogenase in ethanol metabolism. Psychosom. Med. 28: 405.

    Google Scholar 

  • WARTBURG, J-P., PAPENBERG, J. AEBI, H., 1965, An atypical human alcohol dehydrogenase. Can. J. Biochem. 43: 889.

    Google Scholar 

  • WARTBURG, J-P. SCHÜRCH, P. M., 1968, Atypical human liver dehydrogenase. Ann. N. Y. Acad. Sci. 151:936.

    Google Scholar 

  • VESELL, E. S., 1972, Ethanol metabolism: Regulation by genetic factors in normal volunteers under a controlled environment and the effect of chronic ethanol administration. Ann. N. Y. Acad. Sci. 197:79.

    Google Scholar 

  • VESELL, E. S., PAGE, J. G. PASSANANTI, G. T., 1971, Genetic and environmental factors affecting ethanol metabolism in man. Clin. Pharmacol. Ther. 12: 192.

    Google Scholar 

  • WHITNEY, G., 1972, Relationship between alcohol preference and other behaviors in laboratory mice. International Symposium Biological Aspects of Alcohol Consumption. Helsinki 1971. Ed by 0. Forsander K. Eriksson. Finnish Foundation for Alcohol Studies 20: 151.

    Google Scholar 

  • WILLIAMS, R. J., 1947, The etiology of alcoholism; A working hypothesis involving the interplay of hereditary and environmental factors. Quart. J. Stud. Alc. 7:567.

    Google Scholar 

  • WINOKUR, G., 1967, X-borne recessive genes in alcoholism. Lancet 2, 466.

    Google Scholar 

  • WINOKUR, G. CLAYTON, P. J., 1968, Family history studies IV. Comparison of male and female alcoholics. Quart J. Stud. Alc. 29:885.

    Google Scholar 

  • WINOKUR, G., REICH, T., RIMMER, J. PITTS, F. N., 1970, Alcoholism III. Diagnosis and familial psychiatric illness in 259 alcoholic propands. Arch. Gen. Psychiat. 23: 104.

    Article  PubMed  Google Scholar 

  • WOLFF, P. H., 1972, Ethnic differences in alcohol sensitivity. Science 175: 449.

    Google Scholar 

  • WOLFF, P. H., 1973, Vasomotor sensitivity to alochol in diverse mongoloid populations. Amer. J. Hum. Genet. 25:193.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Laboratories, State Alcohol Monopoly Alko, Box 350, SF-00101, Helsinki 10, Finland

    Kalervo Eriksson Ph.D.

Authors
  1. Kalervo Eriksson Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Jackson Laboratory, Bar Harbor, Maine, 04609, USA

    Basil E. Eleftheriou Ph.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1975 Plenum Press, New York

About this chapter

Cite this chapter

Eriksson, K. (1975). Alcohol Imbibition and Behavior: A Comparative Genetic Approach. In: Eleftheriou, B.E. (eds) Psychopharmacogenetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7697-6_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-7697-6_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7699-0

  • Online ISBN: 978-1-4615-7697-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation