Abstract
The study of rabies virus and its components with hybridoma antibodies is of particular importance for several reasons. First, rabies, a rhabdovirus, is unique in its ability to infect all warm-blooded animals, including man. It is a strictly neurotropic virus, replicating in neurons and spreading through axons and nerve cells from the site of infection to the central nervous system; the virus is never detected in the blood of infected animals. Transmission occurs in most cases by bites or scratches and only on very rare occasions by inhalation.
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Flamand, A., Wiktor, T. J., and Koprowski, H., 1980a, Use of hybridoma monoclonal antibodies in the detection of antigenic differences between rabies and rabies-related virus proteins. I. The nucleocapsid, J. Gen. Virol, (in press).
Flamand, A., Wiktor, T. J., and Koprowski, H., 1980b, Use of hybridoma monoclonal antibodies in the detection of antigenic differences between rabies and rabies-related virus proteins. II. The glycoprotein, J. Gen. Virol, (in press).
Gerhard, W., and Webster, R. G., 1978, Antigenic drift in influenza A viruses. I. Selection and characterization of antigenic variants of A/PR/8/34 (H0N1) influenza virus with monoclonal antibodies, J. Exp. Med. 148:383.
Sokol, F., Stancek, D., and Koprowski, H., 1971, Structural proteins of rabies virus, J. Virol. 7:241.
Wiktor, T. J., and Koprowski, H., 1978, Monoclonal antibodies against rabies virus produced by somatic cell hybridization: Detection of antigenic variants, Proc. Natl. Acad. Sci. USA 75:3938.
Wiktor, T. J., and Koprowski, H., 1980, Antigenic variants of rabies virus, J. Exp. Med. (in press).
Wiktor, T. J., Flamand, A., and Koprowski, H., 1980, Use of monoclonal antibodies in diagnosis of rabies virus infection and differentiation of rabies and rabies-related viruses, J. Virol. Methods 1: 33.
Zaides, V. M., Krotova, L. I., Selimova, L. M., Selimov, M. A., Elbert, L. B., and Zhdanov, V. M., 1979, Reevaluation of the proteins in rabies virus particles, J. Virol. 29:1226.
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© 1980 Plenum Press, New York
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Koprowski, H., Wiktor, T. (1980). Monoclonal Antibodies against Rabies Virus. In: Kennett, R.H., McKearn, T.J., Bechtol, K.B. (eds) Monoclonal Antibodies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7505-4_19
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DOI: https://doi.org/10.1007/978-1-4615-7505-4_19
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