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Murine T-Cell Differentiation Antigens Detected by Monoclonal Antibodies

  • Chapter
Monoclonal Antibodies

Abstract

Monoclonal antibodies can now be produced in unlimited quantities by making “hybridomas” (Köhler and Milstein, 1975). These antibodies introduced a new era in serology, making it possible to distinguish single antigenic specificities among a complex array of antigens. Monoclonal antibodies have been used to discover new antigenic specificities on the surface of lymphoid cells of rats and mice (Williams et al, 1977; Springer et al, 1978a,b; Ledbetter and Herzenberg, 1979; Stern et al, 1978; Trowbridge, 1978), and to characterize biochemically many of the molecules that express these antigens. In other cases monoclonal antibodies have made it possible to distinguish multiple antigenic sites on complex molecules. For example, using monoclonal antibodies, five allotypic sites have been defined and located on mouse IgG2a heavy chain (Oi and Herzenberg, 1979a,b). Similarly, two allotypic sites on mouse immunoglobulin D (IgD) have been located with monoclonal antibodies (Goding, 1980).

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Author information

Authors and Affiliations

  1. Department of Genetics, Stanford University School of Medicine, Stanford, California, 94305, USA

    Jeffrey A. Ledbetter, James W. Goding, Takeshi Tokuhisa & Leonard A. Herzenberg

Authors
  1. Jeffrey A. Ledbetter
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  2. James W. Goding
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  3. Takeshi Tokuhisa
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  4. Leonard A. Herzenberg
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Editor information

Editors and Affiliations

  1. University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

    Roger H. Kennett  & Thomas J. McKearn  & 

  2. The Wistar Institute, Philadelphia, Pennsylvania, USA

    Kathleen B. Bechtol

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© 1980 Plenum Press, New York

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Ledbetter, J.A., Goding, J.W., Tokuhisa, T., Herzenberg, L.A. (1980). Murine T-Cell Differentiation Antigens Detected by Monoclonal Antibodies. In: Kennett, R.H., McKearn, T.J., Bechtol, K.B. (eds) Monoclonal Antibodies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7505-4_14

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  • DOI: https://doi.org/10.1007/978-1-4615-7505-4_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-7507-8

  • Online ISBN: 978-1-4615-7505-4

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