Abstract
For a number of reasons, receptor-mediated endocytosis provides an ideal system in which a biological process can be approached with mathematical modeling. Much progress has been made in the ability to define and measure individual steps in the complex multistep process of endocytosis, and the use of radiolabeled ligands makes quantitative kinetic data accessible to the modeler. In this chapter we briefly explore the role of mathematical modeling in interpreting experimental data and in elucidating details about the pathway of receptor-mediated endocytosis. We first discuss our current view of the endocytic pathway, emphasizing the kinetic and mechanistic possibilities for both ligand and receptor as they embark on their cellular journeys. We then review some of the published modeling of endocytosis; finally, we focus on the early steps in the binding and internalization of ligand and discuss in some detail the mathematics of these aspects of the process. Two particularly well-described systems are used to illustrate the endocytic pathway: the hepatic asialoglycoprotein (ASGP) receptor and the low-density lipoprotein (LDL) receptor.
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© 1985 Plenum Press, New York
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Klausner, R., Van Renswoude, J., Harford, J., Wofsy, C., Goldstein, B. (1985). Mathematical Modeling of Receptor-Mediated Endocytosis. In: Pastan, I., Willingham, M.C. (eds) Endocytosis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6904-6_9
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DOI: https://doi.org/10.1007/978-1-4615-6904-6_9
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