• Ira Pastan
  • Mark C. Willingham

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Ira Pastan, Mark C. Willingham
    Pages 1-44
  3. Alexander Levitzki
    Pages 45-68
  4. John A. Hanover, Robert B. Dickson
    Pages 131-161
  5. Pierre J. Courtoy, Joël Quintart, Joseph N. Limet, Colette De Roe, Pierre Baudhuin
    Pages 163-194
  6. Sjur Olsnes, Kirsten Sandvig
    Pages 195-234
  7. Frederick R. Maxfield
    Pages 235-257
  8. Richard Klausner, Jos Van Renswoude, Joe Harford, Carla Wofsy, Byron Goldstein
    Pages 259-279
  9. Mark C. Willingham, Ira Pastan
    Pages 281-321
  10. Back Matter
    Pages 323-326

About this book


Many hormones, growth factors, and other large molecules bind to speci­ Jic receptors on the surface of eukaryotic cells and are rapidly taken into these cells. Current techniques of protein purification have made available sufficient amounts of these molecules so that detailed studies of their interaction with cells could be carried out. These studies have been performed on just a few types of cells, but it is clear that all types of cells carry out a_ similar internalization process. The realization that cells rapidly internalize hormones, growth factors, transport proteins, toxins, and viruses has led many investigators to address a similar series of questions: (1) What is the pathway by which macromolecules enter cells? (2) Do all macromolecules enter by the same pathway? (3) What is the function of internalization of large molecules? (4) What is the biochemical mechan­ ism of internalization? In this volume we have tried to provide answers to these and related questions. To do this we have asked scientists currently active in the field to contribute chapters in their special areas of interest. The selection of the material covered reflects in large part areas of active research. Because of space limitations some important areas have not been covered as fully as we would have liked in this volume, but will be covered in a future volume. Our aim has been to present a consistent view and, when disagreements exist, to point out the basis of such disagreements.


cell cells growth growth factor hormone hormones molecule protein proteins research transport

Editors and affiliations

  • Ira Pastan
    • 1
  • Mark C. Willingham
    • 1
  1. 1.Laboratory of Molecular BiologyNational Cancer Institute, National Institutes of HealthBethesdaUSA

Bibliographic information