Abstract
Consistent evidence from epidemiologic, clinical, and biochemical studies indicates that an elevated plasma homocysteine concentration is a risk factor for premature vascular disorders. Several chapters of this book discuss the evidence linking hyperhomocysteinemia to vascular disease, as well as possible mechanisms by which hyperhomocysteinemia may promote athero-genesis. In order to obtain perspective on hyperhomocysteinemia as a risk factor for coronary heart disease (CHD), several pertinent questions need answers. For example, how common is hyperhomocysteinemia in a population with a high CHD prevalence? Which factors determine homocysteine concentrations in the circulation? Is it feasible and appropriate to modulate determinants of plasma homocysteine concentrations to achieve lower plasma homocysteine concentrations in the general population?
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Ubbink, J.B. (1997). Vitamin Status and Hyperhomocysteinemia in a Healthy Population. In: Graham, I., Refsum, H., Rosenberg, I.H., Ueland, P.M., Shuman, J.M. (eds) Homocysteine Metabolism: From Basic Science to Clinical Medicine. Developments in Cardiovascular Medicine, vol 196. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5771-5_13
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DOI: https://doi.org/10.1007/978-1-4615-5771-5_13
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