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The Role of Cytokines in Alzheimer’s Disease

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Neurochemistry

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Abstract

In Alzheimer’s disease (AD), acute-phase proteins such as α1-antichymotrypsin (1,2), α1-antitrypsin (3,4), apolipoproteins (5–7), C-reactive-protein (8) and the adhesion molecule ICAM-1 (9,10) have been found in cerebral amyloid plaques. The relationship between α1-antichymotrypsin and the 4kD β-amyloid-protein (βA4) or the amyloid-precursor protein (APP) is unclear. α1-Antichymotrypsin is not present in all amyloid plaques suggesting that the presence of βA4 is not sufficient to initiate acute-phase protein synthesis in vivo (11). The effects of α1-antichymotrypsin on the development of senile plaques are not well understood.There are contradictory data suggesting an involvement of α1-antichymotrypsin either in the aggregation and assembly of βA4 into filaments or an involvement of α1-antichymotrypsin as a factor which keeps βA4 in solution (12,13).

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Author information

Authors and Affiliations

  1. Department of Psychiatry, Medical School, University of Freiburg, Freiburg, Germany

    M. Hüll, B. L. Fiebich & K. Lieb

  2. Department of Neuropathology, Medical School, University of Freiburg, Freiburg, Germany

    B. Volk

Authors
  1. M. Hüll
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  2. B. L. Fiebich
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  3. K. Lieb
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  4. B. Volk
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  5. M. Berger
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  6. J. Bauer
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Editor information

Editors and Affiliations

  1. University Hospital, Groningen, The Netherlands

    Albert Teelken  & Jaap Korf  & 

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© 1997 Springer Science+Business Media New York

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Hüll, M., Fiebich, B.L., Lieb, K., Volk, B., Berger, M., Bauer, J. (1997). The Role of Cytokines in Alzheimer’s Disease. In: Teelken, A., Korf, J. (eds) Neurochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5405-9_5

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  • DOI: https://doi.org/10.1007/978-1-4615-5405-9_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7468-8

  • Online ISBN: 978-1-4615-5405-9

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