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Thermodynamic State Diagrams of Oligonucleotide Triple Helices

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Triple Helix Forming Oligonucleotides

Part of the book series: Perspectives in Antisense Science ((DARE,volume 2))

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Summary

Understanding of the cellular role of nucleic acid triple helices and utilization of triple-helix forming oligonucleotides in biotechnology, diagnostics, and therapeutics depend on development of an understanding of triple-helix formation as a function of the nucleic acid components and solution conditions. This article reviews developments in nucleic acid triple-helix thermodynamics with emphasis on the construction and interpretation of state diagrams as a means of characterizing the complex behavior of triple-helix forming oligonucleotides.1

This paper is a truncated version of a more extensive review of triple helix thermodynamics (1).

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Authors
  1. G. Eric Plum
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  2. K. J. Breslauer
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Editors and Affiliations

  1. CNRS, France

    Claude Malvy , Annick Harel-Bellan  & Linda L. Pritchard ,  & 

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Plum, G.E., Breslauer, K.J. (1999). Thermodynamic State Diagrams of Oligonucleotide Triple Helices. In: Malvy, C., Harel-Bellan, A., Pritchard, L.L. (eds) Triple Helix Forming Oligonucleotides. Perspectives in Antisense Science, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5177-5_3

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  • DOI: https://doi.org/10.1007/978-1-4615-5177-5_3

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