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Triple Helix Forming Oligonucleotides

  • Claude Malvy
  • Annick Harel-Bellan
  • Linda L. Pritchard

Part of the Perspectives in Antisense Science book series (DARE, volume 2)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Background and Structural Aspects

  3. The Biology of Triple Helices

    1. Front Matter
      Pages 99-99
    2. L. James Maher
      Pages 101-115
    3. Scot W. Ebbinghaus, Nadarajah Vigneswaran, Charles M. Mayfield, David T. Curiel, Donald M. Miller
      Pages 117-127
    4. Fedor Svinarchuk, Claude Malvy
      Pages 145-157
    5. Marina Kochetkova, Mary Frances Shannon
      Pages 159-166
    6. Karen M. Vasquez, Peter M. Glazer
      Pages 167-179
    7. François-Xavier Barre, Linda L. Pritchard, Annick Harel-Bellan
      Pages 181-192
    8. Sergei M. Mirkin
      Pages 193-222
    9. Anne-Laure Guieysse, Daniele Praseuth
      Pages 223-231
    10. Kyonggeun Yoon, Jörg Jendis, Karin Moelling
      Pages 233-242
  4. New Developments and Applications

    1. Front Matter
      Pages 243-243
    2. Thomas Bentin, Peter E. Nielsen
      Pages 245-255
    3. Christophe Escudé, Thérèse Garestier
      Pages 257-271
    4. Maxim D. Frank-Kamenetskii
      Pages 285-294
  5. Back Matter
    Pages 295-297

About this book

Introduction

Sequence-specific DNA binding ligands, amongst which triple helix forming oligonucleotides are the most efficient as yet, represent promising tools in a number of fields. One of their most promising applications is as antiviral tools: they can specifically target a viral gene, even if it is integrated into the host genome, and be used to specifically inactivate the viral gene or even destroy the cells harboring this gene. However, from science fiction to science there remains a gap; and we are at the moment on the threshold of this fascinating field. Triple Helix Forming Oligonucleotides considers the different aspects of the design and improvement, current or future, of these molecules and their structural analysis, as well as their applications, with special emphasis on the attempts to obtain biological effects of these potentially important tools. What emerges is that the current state of the research is encouraging, and that these molecules are already useful in some biotechnology applications.

Keywords

DNA Nucleotide Purine RNA Vivo genes microscopy transcription

Editors and affiliations

  • Claude Malvy
    • 1
  • Annick Harel-Bellan
    • 1
  • Linda L. Pritchard
    • 1
  1. 1.CNRSFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-5177-5
  • Copyright Information Kluwer Academic Publishers 1999
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-7358-2
  • Online ISBN 978-1-4615-5177-5
  • Series Print ISSN 1566-0389
  • Buy this book on publisher's site