Summary
The applications of triple helix forming oligonucleotides can be limited by the relatively low stability of triple helical complexes. Ligands which can bind more tightly to triple helical DNA than to double-helical DNA can stabilize triple helices. This chapter reviews the structural aspects of triple helix ligand complexes and briefly discusses the possible use or role of triple helix stabilizing agents in triplex-based strategies or mechanisms.
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Escudé, C., Garestier, T. (1999). Triple Helix Stabilizing Agents. In: Malvy, C., Harel-Bellan, A., Pritchard, L.L. (eds) Triple Helix Forming Oligonucleotides. Perspectives in Antisense Science, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5177-5_19
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DOI: https://doi.org/10.1007/978-1-4615-5177-5_19
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