Abstract
PU.1 has been reported to control the expression of an increasing number of myeolid-specific genes, including the macrophage CSF receptor (M-CSFR). Macrophage colony stimulating factor (M-CSF) and its receptor are required for proliferation, differentiation, and maturation of monocytes/macrophages.
To investigate the mechanism of M-CSFR expression, we studied the binding of PU.1 to M-CSFR promoter during monocyte to macrophage differentiation. We show that induction of a highly phosphorylated form of PU.1 positively correlates with monocyte to macrophage maturation.
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Sposi, N.M., Marziali, G., Pelosi, E., Battistini, A., Testa, U., Peschle, C. (1999). Pattern of PU.1 Binding to M-CSF Receptor Promoter During Monocyte to Macrophage Maturation. In: Abraham, N.G., Tabilio, A., Martelli, M., Asano, S., Donfrancesco, A. (eds) Molecular Biology of Hematopoiesis 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4797-6_33
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DOI: https://doi.org/10.1007/978-1-4615-4797-6_33
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