Skip to main content
SpringerLink
Log in

The Biology of CSF-1 and Its Receptor

  • Chapter
Macrophage Biology and Activation

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 181))

Abstract

The constant renewal of blood cells in vertebrate species depends on the proliferation and differentiation of hematopoietic stem cells in the bone marrow (Harrison et al. 1988). These cells in turn give rise to progenitor cells which are committed to more restricted pathways of differentiation. The survival, proliferation, and differentiation of these progenitor cells are regulated by the colony stimulating factors (CSFs), so named because of their ability to promote the in vitro proliferation and differentiation of single progenitor cells into macroscopic colonies with discernible differentiated cell types (Pluznik and Sachs 1965; Bradley and Metcalf 1966; Ichikawa et al. 1966). This group of hematopoietic growth factors includes interleukin-3 (IL-3), granulocyte-macrophage colony stimulating factor (GM-CSF), granulocyte colony stimulating factor (G-CSF), interleukin-5 (IL-5), and colony stimulating factor-1 (CSF-1) (reviewed in STANLEY and JUBINSKY 1984; METCALF 1986).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Akagawa KS, Kamoshita K, Tokunaga T (1988) Effects of granulocyte-macrophage colony stimulating factor and colony stimulating factor-1 on the proliferation and differentiation of murine alveolar macrophages. J Immunol 141: 3383–3390.

    PubMed  CAS  Google Scholar 

  • Arceci RJ, Shanahan F, Stanley ER, Pollard JW (1989) Temporal expression and locations of colony stimulating factor-1 (CSF-1) and its receptor in the female reproductive tract are consistent with CSF-1 regulated placental development. Proc Natl Acad Sci USA 86: 8818–8822.

    PubMed  CAS  Google Scholar 

  • Ashmun RA, Look AT, Roberts WM, Roussel MF, Seremetis S, Ohtsuka M, Sherr CJ (1989) Monoclonal antibodies to the human CSF-1 receptor (c-fms proto-oncogene product) detect epitopes on normal mononuclear phagocytes and on human myeloid leukemic blast cells. Blood 73: 827–837.

    PubMed  CAS  Google Scholar 

  • Athanassakis I, Bleackley RC, Poetkau V, Guilbert L, Barr PJ, Wegman TG (1987) The immunostimulatory effect of T cells and T cell lymphokines on murine fetally derived placental cells. J Immunol 138: 37–44.

    PubMed  CAS  Google Scholar 

  • Baccarini M, Sabatini DM, App H, Rapp UR, Stanley ER (1990) Colony stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product. EMBO J 9: 3649–3657.

    PubMed  CAS  Google Scholar 

  • Baccarini M, Gill GN, Stanley ER (1991) Epidermal growth factor stimulates phosphorylation of RAF-1 independently of receptor autophosphorylation and internalization. J Biol Chem (in press).

    Google Scholar 

  • Barlow DP, Bucan M, Lebract H, Hogan BLM, Gough NM (1987) Close genetic and physical linkage between the murine haematopoietic growth factor genes GM-CSF and multi-CSF (IL-3). EMBO J 6: 617–623.

    PubMed  CAS  Google Scholar 

  • Bartelmez SH, Stanley ER (1985) Synergism between hemopoietic growth factors (HGFs) detected by their effects on cells bearing receptors for a lineage-specific HGF: assay of hemopoietin-1. J Cell Physiol 122: 370–378.

    PubMed  CAS  Google Scholar 

  • Bartelmez SH, Bradley TR, Bertoncello I et al. (1989) Interleukin-1 plus interleukin-3 plus colony stimulating factor-1 are essential for clonal proliferation of primitive myeloid bone marrow cells. Exp Hematol 17: 240–245.

    PubMed  CAS  Google Scholar 

  • Bartocci A, Pollard JW, Stanley ER (1986) Regulation of colony-stimulating factor-1 during pregnancy. J Exp Med 164: 956–961.

    PubMed  CAS  Google Scholar 

  • Bartocci A, Mastrogiannis DS, Migliorati G, Stockert RJ, Wolkoff AW, Stanley ER (1987) Macrophages specifically regulate the concentration of their own growth factor in the circulation. Proc Natl Acad Sci USA 84: 6173–6183.

    Google Scholar 

  • Baumbach WR, Colston EM, Cole MD (1987) Integration of the BALB/c ecotropic provirus into the colony stimulating factor-1 growth factor locus in a myc retrovirus-induced murine monocyte tumor. J Virol 62: 3151–3155.

    Google Scholar 

  • Becker SJ, Warren MK, Haskill S (1987) Colony stimulating factor-induced monocyte survival and differentiation into macrophages in serum-free cultures. Immunology 139: 3703–3709.

    CAS  Google Scholar 

  • Bermudez L, Young LS (1990) Macrophage colony stimulating factor (CSF-1) stimulates murine and human macrophages to kill mycobacterium avium complex (MAC), (submitted for publication).

    Google Scholar 

  • Besmer P, Murphy JE, George PC et al. (1986) A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. Nature 320: 415–421.

    PubMed  CAS  Google Scholar 

  • Boocock CA, Jones GE, Stanley ER, Pollard JW (1989) Colony stimulating factor-1 induces rapid behavioral responses in the mouse macrophage cell line, BAC 1.2F5. J Cell Sci 93: 447–456.

    PubMed  CAS  Google Scholar 

  • Bot FJ, Van Eijk L, Broeders L, Aarden LA, Lowenberg B (1989) Interleukin-6 synergizes with M-CSF in the formation of macrophage colonies from purified human marrow progenitor cells. Blood 73: 435–437.

    PubMed  CAS  Google Scholar 

  • Bradley TR, Metcalf D (1966) The growth of mouse bone marrow cells in vitro. Aust J Exp Biol Med Sci 44: 287–299.

    PubMed  CAS  Google Scholar 

  • Bradley TR, Stanley ER, Sumner MT (1971) Factors from mouse tissues stimulating colony growth of mouse bone marrow cells in vitro. Aust J Exp Biol Med Sci 49: 595–603.

    PubMed  CAS  Google Scholar 

  • Branch DR, Turner AR, Guilbert LJ (1989) Synergistic stimulation of proliferation by the monokines tumor necrosis factor-alpha and colony stimulating factor-1. Blood 73: 307–311.

    PubMed  CAS  Google Scholar 

  • Bravo R, Neuberg M, Burckhardt J, Almendral J, Wallich R, Muller R (1987) Involvement of common and cell-type specific pathways in c-fos gene control: stable induction by cAMP in macrophages. Cell 48: 251–260.

    PubMed  CAS  Google Scholar 

  • Browning PJ, Bunn HF, Cline A, Shuman M, Nienhuis AW (1986) “Replacement” of COOH-terminal truncation of v-fms with c-fms sequences markedly reduces transformation potential. Proc Natl Acad Sci USA 83: 7800–7804.

    PubMed  CAS  Google Scholar 

  • Broxmeyer HE, Williams DE, Cooper S et al. (1987) Comparative effects in vivo of recombinant murine interleukin-3, natural murine colony stimulating factor-1 and recombinant murine granulocyte-macrophage colony stimulating factor on myelopoiesis in mice. J Clin Invest 79: 721–730.

    PubMed  CAS  Google Scholar 

  • Byrne PV, Guilbert LJ, Stanley ER (1981) Distribution of cells bearing receptors for a colony-stimulating factor (CSF-1) in murine tissues. J Cell Biol 91: 848–853.

    PubMed  CAS  Google Scholar 

  • Caracciolo D, Shirsat N, Wong GG, Lange B, Clark S, Rovera G (1987) Recombinant human macrophage colony stimulating factor (M-CSF) requires subliminal concentrations of granulocyte-macrophage (GM)-CSF for optimal stimulation of human macrophage colony formation in vitro. J Exp Med 166: 1851–1860.

    PubMed  CAS  Google Scholar 

  • Cenci E, Bartocci A, Puccetti P, Mocci S, Stanley ER, Bistoni F (1991) Macrophage colony stimulating factor in murine candidiasis: serum and tissue levels during infection and protective effect of exogenous administration. Infect Immun (in press).

    Google Scholar 

  • Cerdan C, Courcoul M, Rozanajaona D et al. (1990) Activated but not resting T cells or thymocytes express colony-stimulating factor 1 mRNA without co-expressing c-fms mRNA. Eur J Immunol 20: 331–335.

    PubMed  CAS  Google Scholar 

  • Cerretti DP, Wignall J, Anderson D et al. (1988) Human macrophage colony stimulating factor: alternative RNA and protein processing from a single gene. Mol Immunol 25: 761–770.

    PubMed  CAS  Google Scholar 

  • Cheers C, Hill M, Haight AM, Stanley ER (1989) Stimulation of macrophage phagocytic but not bactericidal activity by colony stimulating factor-1. Infect Immun 57: 1512–1516.

    PubMed  CAS  Google Scholar 

  • Chen BD, Clark CR (1986) Interleukin-3 (IL-3) regulates the in vitro proliferation of both blood monocytes and peritoneal exudate macrophages. Synergism between a macrophage lineage-specific colony stimulating factor (CSF-1) and IL-3. J Immunol 137: 563–570.

    PubMed  CAS  Google Scholar 

  • Chen BDM, Clark CH, Chou T (1988) Granulocyte-macrophage colony stimulating factor stimulates monocyte and tissue macrophage proliferation and enhances their responsiveness to macrophage colony stimulating factor. Blood 71: 997–1002.

    PubMed  CAS  Google Scholar 

  • Chodakewitz JA, Lacy J, Edwards SE, Birchall N, Coleman DL (1990) Macrophage colony stimulating factor production by murine and human keratinocytes: enhancement by bacterial lipo-polysaccharide. J Immunol 144: 2190–2196.

    PubMed  CAS  Google Scholar 

  • Chong KT, Langlois L (1988) Enhancing effect of M-CSF on leukocytes and host defense in normal and immunosuppressed mice. FASEB J 2: A1474.

    Google Scholar 

  • Chong KT, Langlois L (1989) Recombinant human macrophage colony stimulating factor (M-CSF) enhanced murine host defense against lethal Candida albicans infections. Annual Meeting of the American Society of Microbiology 89: 134A.

    Google Scholar 

  • Chen BDM, Lin HS, Hsu S (1983) Tumor-promoting phorbol esters inhibit the binding of colony-stimulating factor (CSF-1) to murine peritoneal exudate macrophages. J Cell Physiol 116: 207–212.

    PubMed  CAS  Google Scholar 

  • Clark CR, Chen BDM, Boros DL (1988) Macrophage progenitor cell and colony stimulating factor production during granulomatous schistosomiasis mansoni in mice. Intect Immun 56: 2680–2685.

    CAS  Google Scholar 

  • Coussens L, Van Beveren C, Smith D et al. (1986) Structural alteration of viral homologue of receptor protooncogene fms at carboxyl terminus. Nature 320: 277–280.

    PubMed  CAS  Google Scholar 

  • Das SK, Stanley ER (1982) Structure-function studies of a colony stimulating factor (CSF-1). J Biol Chem 257: 679–684.

    Google Scholar 

  • Das SK, Stanley ER, Guilbert LJ, Forman LW (1981) Human colony stimulating factor (CSF-1) radioimmunoassay: resolution of three subclasses of human colony stimulating factors. Blood 58: 630–641.

    PubMed  CAS  Google Scholar 

  • Downing JR, Rettenmier CW, Sherr CJ (1988) Ligand-induced tyrosine kinase activity of the colony stimulating factor-1 receptor in a murine macrophage cell line. Mol Cell Biol 8: 1795–1799.

    PubMed  CAS  Google Scholar 

  • Downing JR, Roussel MF, Sherr CJ (1989) Ligand and protein kinase C downmodulate the colony stimulating factor-1 receptor by independent mechanisms. Mol Cell Biol 9: 2890–2896.

    PubMed  CAS  Google Scholar 

  • Dubreuil P, Torres H, Courcoul MA, Birg F, Mannoni P (1988) c-fms expression is a molecular marker of human acute myeloid leukemias. Blood 72: 1081–1085.

    PubMed  CAS  Google Scholar 

  • Dynan WS, Sazer S, Tjian R, Schimke RT (1986) Transcription factor Spl recognizes a DNA sequence in the mouse dihydrofolate reductase promoter. Nature 349: 246–248.

    Google Scholar 

  • Elford PR, Felix R, Cecchini M, Trechsel U, Fleisch H (1987) Murine osteoblast-like cells and the osteogenic cell MC 3T3-E1 release a macrophage colony-stimulating activity in culture. Calcif Tissue Int 41: 151–156.

    PubMed  CAS  Google Scholar 

  • Felix R, Cecchiri MG, Fleisch H (1990) Macrophage colony stimulating factor restores in vivo bone resorption in the op/op osteopetrotic mouse. Endocrinology 127: 2592–2594.

    PubMed  CAS  Google Scholar 

  • Fibbe WE, Van Damme J, Billian A et al. (1988) Interleukin-1 induces human marrow stromal cells in long-term culture to produce granulocyte colony-stimulating factor and macrophage colony-stimulating factor. Blood 71: 430–435.

    PubMed  CAS  Google Scholar 

  • Gaffney EV, Lingenfelter SE, Koch GA, Lisi PJ, Chu CW, Tsai SC (1988) Regulation by interferon-γ of function in the acute monocytic leukemia cell line, THP-1. J Leukocyte Biol 43: 248–255.

    PubMed  CAS  Google Scholar 

  • Garnick MB, Stoudemire JB (1990) Preclinical and clinical evaluation of recombinant human macrophage colony stimulating factor. Int J Cell Cloning 8[Suppl 1]: 356–373.

    PubMed  Google Scholar 

  • Geissler K, Harrington M, Srivastaua C, Leemhais T, Tricot G, Broxmeyer HE (1989) Effects of recombinant human colony stimulating factors (CSF) (GM-CSF, G-CSF and CSF-1) on human monocyte/macrophage differentiation. J Immunol 143: 140–146.

    PubMed  CAS  Google Scholar 

  • Gendleman H, Orenstein JM, Martin MA et al. (1988) Efficient isolation and propagation of human immunodeficiency virus on recombinant colony stimulating factor-1-treated monocytes. J Exp Med 167: 1428–1441.

    Google Scholar 

  • Gilbert HS, Praloran V, Stanley ER (1989) Increased circulating CSF-1 (M-CSF) in myeloproliferative disease: association with myeloid metaplasia and peripheral bone marrow extension. Blood 74: 1231–1234.

    PubMed  CAS  Google Scholar 

  • Gisselbrecht S, Fichelson S, Sola B et al. (1987) Frequent c-fms activation by proviral insertion in mouse myeloblastic leukemias. Nature 329: 259–261.

    PubMed  CAS  Google Scholar 

  • Gisselbrecht S, Sola B, Fichelson S et al. (1989) The murine M-CSF gene is localized on chromosome 3. Blood 73: 1742–1746.

    PubMed  CAS  Google Scholar 

  • Gliniak BC, Rohrschneider LR (1990) Expression of the M-CSF receptor is controlled posttranscriptionally by the dominant actions of GM-CSF or multi-CSF. Cell 63: 1073–1083.

    PubMed  CAS  Google Scholar 

  • Groffen J, Heisterkamp N, Spurr N, Dana S, Wasmuth JJ, Stephenson JR (1983) Chromosomal localization of the human c-fms oncogene. Nucleic Acids Res 11: 6331–6339.

    PubMed  CAS  Google Scholar 

  • Guilbert LJ, Stanley ER (1980) Specific interaction of murine colony-stimulating factor with mononuclear phagocytic cells. J Cell Biol 85: 153–159.

    PubMed  CAS  Google Scholar 

  • Guilbert LJ, Stanley ER (1984) Modulation of receptors for the colony stimulating factor CSF-1 by bacterial lipopolysaccharide and CSF-1. J Immunol Methods 73: 17–28.

    PubMed  CAS  Google Scholar 

  • Guilbert LJ, Stanley ER (1986) The interaction of 125I-colony-stimulating factor-1 with bone marrow derived macrophages. J Biol Chem 261: 4024–4032.

    PubMed  CAS  Google Scholar 

  • Hamilton JA, Stanley ER, Burgess AW, Shadduck R (1980) Stimulation of macrophage plasminogen activator by colony stimulating factors. J Cell Physiol 103: 435–445.

    PubMed  CAS  Google Scholar 

  • Hamilton JA, Vairo G, Lingelbach SR (1988) Activation and proliferation signals in murine macrophages. Stimulation of glucose uptake by hemopoietic growth factors and other agents. J Cell Physiol 134: 405–412.

    PubMed  CAS  Google Scholar 

  • Guilbert LJ, Nelson DJ, Hamilton JA, Williams N (1983) The nature of 12-0-tetradecanoylphorbol-13-acetate (TPA) stimulated hemopoiesis. Colony stimulating factor (CSF) requirement for colony formation and the effect of 125I-CSF-1 binding. J Cell Physiol 115: 226–282.

    Google Scholar 

  • Hamilton JA, Veis N, Bordun AM, Vairo G, Gonda TJ, Phillips WA (1989) Activation and proliferation signals in murine macrophages: relationships among c-fos and c-myc expression, phosphoinositide hydrolysis, superoxide formation and DNA synthesis. J Cell Physiol 141: 618–626.

    PubMed  CAS  Google Scholar 

  • Hampe A, Gobet M, Sherr CJ, Galibert F (1984) The nucleotide sequence of the feline retroviral oncogene v-fms shows unexpected homology with oncogenes encoding tyrosine-specific protein kinases. Proc Natl Acad Sci USA 81: 85–89.

    PubMed  CAS  Google Scholar 

  • Hampe A, Shamoon BM, Gobet M, Sherr CJ, Galibert F (1989) Nucleotide sequence and structural organization of the human fms proto-oncogene. Oncogene Res 4: 9–17.

    PubMed  CAS  Google Scholar 

  • Harrison D, Astle C, Lerner C (1988) Number and continuous proliferative pattern of transplanted premature immunohematopoietic stem cells. Proc Natl Acad Sci USA 85: 822–826.

    PubMed  CAS  Google Scholar 

  • Haskill S, Johnson C, Eierman D, Becker S, Warren K (1988) Adherence induces selective mRNA expression of monocyte mediators and proto-oncogenes. J Immunol 140: 1690–1694.

    PubMed  CAS  Google Scholar 

  • Hattersley G, Dorey E, Horton MA, Chambers TJ (1988) Human macrophage colony stimulating factor inhibits bone resorption by osteoclasts disaggregated from rat bone. J Cell Physiol 137: 199–203.

    PubMed  CAS  Google Scholar 

  • Heard JM, Roussel MF, Rettenmier CW, Sherr CJ (1987a) Synthesis, post-translational processing and autocrine transforming activity of a carboxylterminal truncated form of colony stimulating factor-1. Oncogene Res 1: 423–440.

    PubMed  CAS  Google Scholar 

  • Heard JM, Roussel MF, Rettenmier CW, Sherr CJ (1987b) Multilineage hematopoietic disorders induced by transplantation of bone marrow cells expressing the v-fms oncogene. Cell 51: 663–673.

    PubMed  CAS  Google Scholar 

  • Ho JL, Reed S, Wick EA (1989) Effect of macrophage-colony stimulating factor (M-CSF) on intramacrophage (MO) survival of Leishmania mexicana amazonensis (LMA). Clin Res 37: 431A.

    Google Scholar 

  • Hoggan MD, Halden NF, Buckler CE, Kozak CA (1988) Genetic mapping of the mouse c-fms proto-oncogene to chromosome 18. J Virol 62: 1055–1056.

    PubMed  CAS  Google Scholar 

  • Horiguchi J, Warren MK, Ralph P, Kufe D (1986) Expression of the macrophage specific colony-stimulating factor (CSF-1) during human monocytic differentiation. Biochem Biophys Res Commun 141: 924–930.

    PubMed  CAS  Google Scholar 

  • Horiguchi J, Sherman ML, Sampson-Johannes A, Weber BL, Kufe DW (1988) CSF-1 and c-fms gene expression in human carcinoma cell lines. Biochem Biophys Res Commun 157: 395–401.

    PubMed  CAS  Google Scholar 

  • Hoshina M, Hishio A, Bo M, Boime I, Mochizuki M (1985) The expression of oncogene fms in human chorionic tissue. Acta Obstet Gynecol Jpn 37: 2791–2798.

    CAS  Google Scholar 

  • Huang E, Nocka K, Beier DR et al. (1990) The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of c-kit receptor, the gene product of the W locus. Cell 63: 225–233.

    PubMed  CAS  Google Scholar 

  • Huebner K, Isobe M, Croce CM, Golde DW, Kaufman SE, Gasson JC (1985) The human gene encoding GM-CSF is at 5q21-q32, the chromosome region deleted in the 5q-anomaly. Science 230: 1282–1285.

    PubMed  CAS  Google Scholar 

  • Hume DA, Denkins YM (1989) Activation of macrophages to express cytocidal activity correlates with inhibition of their responsiveness to macrophage colony stimulating factor (CSF-1): involvement of a pertussis-toxin sensitive reaction. Immunol Cell Biol 67: 243–249.

    PubMed  CAS  Google Scholar 

  • Hume DA, Pawli P, Donahue RE, Fidler IJ (1988) The effect of human recombinant macrophage colony stimulating factor (CSF-1) on the murine mononuclear phagocyte system in vivo. J Immunol 141: 3405–3409.

    PubMed  CAS  Google Scholar 

  • Hume DA, Donohue RE, Fidler IJ (1989) The therapeutic effect of human recombinant macrophage colony stimulating factor (CSF-1) in experimental murine metastatic melanoma. Lymphokine Res 8: 69–77.

    PubMed  CAS  Google Scholar 

  • Ichikawa Y, Pluznik DH, Sachs L (1966) In vitro control of the development of macrophage and granulocyte colonies. Proc Natl Acad Sci USA 56: 488–495.

    PubMed  CAS  Google Scholar 

  • Imamura K, Kufe D (1988) Colony stimulating factor-1-induced Na+ influx into human monocytes involves activation of a pertussis toxin-sensitive GTP-binding protein. J Biol Chem 263: 14093–14098.

    PubMed  CAS  Google Scholar 

  • Ishibashi S, Inaba T, Shimano H et al. (1990) Monocyte colony stimulating factor enhances uptake and degradation of acetylated low density lipoproteins and cholesterol esterification in human monocyte derived macrophages. J Biol Chem 265: 14109–14117.

    PubMed  CAS  Google Scholar 

  • Janowska-Wieczorek A, Belch AR, Jacobs A, Bowen D, Paietta E, Stanley ER (1991) Increased circulating colony stimulating factor-1 in patients with preleukemia, leukemia and lymphoid malignancies. Blood (in press).

    Google Scholar 

  • Jaye M, Howk R, Burgess W et al. (1986) Human endothelial cell growth factor: cloning, nucleotide sequence and chromosome localization. Science 233: 541–545.

    PubMed  CAS  Google Scholar 

  • Jubinsky PT, Yeung YG, Sacca R, Li W, Stanley ER (1988) Colony stimulating factor-1 stimulated macrophage membrane protein phosphorylation. In: Kudlow JE, Maclennan DH, Bernstein A, Gottlieb AI (eds) Biology of Growth factors: molecular biology, oncogenes, signal transduction and clinical applications. Plenum, New York, pp 75–90.

    Google Scholar 

  • Kacinski BM, Bloodgood RS, Schwartz PE, Carter D, Stanley ER (1989a) The macrophage colony stimulating factor CSF-1 is produced by human ovarianand endometrial adenocarcinoma-derived cell lines and is present at abnormally high levels in the plasma of ovarian carcinoma patients with active disease. Cold Spring Harbor Symp Quant Biol, Cancer Cells 7: 333–337.

    Google Scholar 

  • Kacinski BM, Stanley ER, Carter D, Chambers JT, Chambers SK, Kohorn EI, Schwartz PE (1989b) Circulating levels of CSF-1 (M-CSF), a lymphohematopoietic cytokine, may be a useful marker of disease status in patients with malignant ovarian neoplasms. Int J Radiat Oncol Biol Phys 17: 159–164.

    PubMed  CAS  Google Scholar 

  • Kanada T, Shikita M, Tsuneoka K, Sakai N, Tomita T, Kanegashi S (1987) J Pharmacobio-Dyn 10: 215.

    PubMed  CAS  Google Scholar 

  • Karbassi A, Becker JM, Foster JJ, Moore RN (1987) Enhanced killing of Candida albicans by murine macrophages treated with macrophage-colony stimulating factor: evidence for augmented expression of mannose receptors. J Immunol 139: 417–421.

    PubMed  CAS  Google Scholar 

  • Kawasaki ES, Ladner MB (1990) Molecular biology of macrophage colony stimulating factor. In: Dexter TM, Garland JM, Testa NG (eds) Colony stimulating factors. Marcel Dekker, New York, pp 155–176.

    Google Scholar 

  • Kawasaki ES, Ladner MB, Wang AM et al. (1985) Molecular cloning of a complementary DNA encoding human macrophage-specific colony stimulating factor (CSF-1). Science 230: 291–296.

    PubMed  CAS  Google Scholar 

  • Komiyama A, Ishiguro A, Kubo T et al. (1988) Increases in neutrophil counts by purified human urinary colony-stimulating factor in chronic neutropenia of childhood. Blood 71: 41–45.

    PubMed  CAS  Google Scholar 

  • Kurland JI, Pelus LM, Ralph P, Bockman RS, Moore MAS (1979) Induction of PGE synthesis in normal and neoplastic macrophages: role of CSF(s) distinct from effects on myeloid progenitor cell. proliferation. Proc Natl Acad Sci USA 76: 2326–2330.

    PubMed  CAS  Google Scholar 

  • Ladner MB, Martin GA, Noble JA, Nikoloff DM, Tal R, Kawasaki ES, White TJ (1987) Human CSF-1: gene structure and alternative splicing of mRNA precursors. EMBO J 6: 2693–2698.

    PubMed  CAS  Google Scholar 

  • Ladner MB, Martin GA, Noble JA, Wittman VP, Warren MK, McGrogan M, Stanley ER (1988) cDNA cloning and expression of murine macrophage colony-stimulating factor from 1929 cells. Proc Natl Acad Sci USA 85: 6706–6710.

    PubMed  CAS  Google Scholar 

  • Laimins LA, Kessel M, Rosenthal N, Khoury G (1983) Viral and cellular enhancer elements. In: Gluzman Y, Shenk T (eds) Communications in molecular biology, enhancers and eukaryotic gene expression. Cold Spring Harbor Laboratory, New York, pp 28–87.

    Google Scholar 

  • Lanotte M, Metcalf D, Dexter TM (1982) Production of monocyte/macrophage colony stimulating factor by preadipocyte cell lines derived from murine marrow stroma. J Cell Physiol 112: 123–127.

    PubMed  CAS  Google Scholar 

  • Le PT, Kurtzberg J, Brandt SJ, Niedel JE, Haynes BF, Singer KH (1988) Human thymic epithelial cells produce granulocyte and macrophage colony-stimulating factors. J Immunol 141: 1211–1217.

    PubMed  CAS  Google Scholar 

  • Le Beau MM, Westbrook CA, Diaz MO et al. (1986) Evidence for the involvement of GM-CSF and fms in the deletion (5q) in myeloid disorders. Science 231: 984–987.

    PubMed  Google Scholar 

  • Le Beau MM, Epstein ND, O’Brien SJ, Nienhuis AW, Yang YC, Clark SC, Rowley, JD (1987) The interleukin-3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of 5q. Proc Natl Acad Sci USA 84: 5913–5917.

    PubMed  Google Scholar 

  • Le Beau MM, Lemons RS, Espinosa R, Larson RA, Arai N, Rowley JD (1989) Interleukin-4 and interleukin-5 map to human chromosome 5 in a region encoding growth factors and receptors and are deleted in myeloid leukemias with a del (5q). Blood 73: 647–650.

    PubMed  Google Scholar 

  • Lee MT, Warren MK (1987) CSF-1-induced resistance to viral infection in murine macrophages. J Immunol 138: 3019–3022.

    PubMed  CAS  Google Scholar 

  • Leibovitch SA, Leibovitch MP, Borycki AG, Harel J (1989) Expression of CSF-1-receptor-related proteins in muscular stem cells. Oncogene Res 4: 157–162.

    PubMed  CAS  Google Scholar 

  • Li W, Stanley ER (1991) Role of dimerization and modification of the CSF-1 receptor in its activation and internalization during the CSF-1 response. EMBO J (in press).

    Google Scholar 

  • Li W, Yeung YG, Stanley ER (1991) Tyrosine phosphorylation of a common 57-kDa protein in growth factor stimulated and transformed cells. J Biol Chem (in press).

    Google Scholar 

  • Lu L, Walker D, Graham CD, Waheed A, Shadduck RK, Broxmeyer HE (1988) Enhancement of release from MHC class II antigen-positive monocytes of hematopoietic colony-stimulating factors CSF-1 and G-CSF by recombinant human tumor necrosis factor-α: synergism with recombinant human interferon-gamma. Blood 72: 34–41.

    PubMed  CAS  Google Scholar 

  • Lyberg T, Stanley ER, Prydz H (1987) Colony stimulating factor-1 induces thromboplastin activity in murine macrophages and human monocytes. J Cell Physiol 132: 367–370.

    PubMed  CAS  Google Scholar 

  • Monos MM (1988) Expression and processing of a recombinant human macrophage colony-stimulating factor in mouse cells. Mol Cell Biol 8: 5035–5039.

    Google Scholar 

  • Masaoka T, Motoyoshi K, Takaku F (1988) Administration of human urinary colony stimulating factor after bone marrow transplantation. Bone Marrow Transplantation 3: 121–127.

    PubMed  CAS  Google Scholar 

  • Matsumoto K, Kakizoe T, Nakagami Y et al. (1987) Clinical trials of CSF-HU (colony stimulating factor derived from human urine: p-100) on granulocytopenia induced by anticancer chemotherapy in urogenital cancer patients. Hinyokika Kiyo 33: 972–982.

    PubMed  CAS  Google Scholar 

  • McNiece IK, Kriegler AB, Bradley TR, Hodgson GS (1986) Subpopulations of mouse bone marrow high-proliferative-potential colony forming cells (HPP-CFC). Exp Hematol 14: 856–860.

    PubMed  CAS  Google Scholar 

  • McNiece IK, Robinson BE, Quesenberry PJ (1988) Stimulation of murine colony forming cells with high proliferative potential by the combination of GM-CSF and CFS-1. Blood 72: 191–195.

    PubMed  CAS  Google Scholar 

  • Metcalf D (1986) The molecular biology and function of the granulocyte-macrophage colony-stimulating factors. Blood 67: 257–267.

    PubMed  CAS  Google Scholar 

  • Miyauchi J, Wang C, Kelleher CA, Wong GG, Clark SC, Minden MD, McCulloch EA (1988) The effects of recombinant CSF-1 on the blast cells of acute myeloblastic leukemia in suspension culture. J Cell Physiol 135: 55–62.

    PubMed  CAS  Google Scholar 

  • Mochizuki DY, Eisenman JR, Conlon PJ, Larsen AD, Tushinski RJ (1987) Interleukin-1 regulates hematopoietic activity, a role previously ascribed to hemopoietin-1. Proc Natl Acad Sci USA 84: 5267–5271.

    PubMed  CAS  Google Scholar 

  • Moore RN, Osmand AP, Dunn JA, Joshi JG, Ronse BT (1988) Substance P augmentation of CSF-1 stimulated in vitro myelopoiesis: a two-signal progenitor restricted, tuftsin-like effect. J Immunol 141: 2699–2703.

    PubMed  CAS  Google Scholar 

  • Moore RN, Osmand AP, Dunn JA, Joshi JG, Koontz JW, Ronse BT (1989) Neurotensin regulation of macrophage colony stimulating factor-stimulated in vitro myelopoiesis. J Immunol 142: 2689–2694.

    PubMed  CAS  Google Scholar 

  • Morgan CJ, Stanley ER (1984) Chemical crosslinking of the mononuclear phagocyte specific growth factor CSF-1 to its receptor at the cell surface. Biochem Biophys Res Commun 119: 35–41.

    PubMed  CAS  Google Scholar 

  • Morrison DK, Kaplan DR, Rapp U, Roberts TM (1988) Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase raf-1 phosphorylation and associated protein kinase activity. Proc Natl Acad Sci USA 85: 8855–8859.

    PubMed  CAS  Google Scholar 

  • Morrison DK, Kaplan DR, Escobedo JA, Rapp U, Roberts TM, Williams LT (1989) Direct activation of the serine/threonine kinase activity of RAF-1 through tyrosine phosphorylation by the PDGF-b receptor. Cell 58: 649–657.

    PubMed  CAS  Google Scholar 

  • Motoyoshi K, Suda T, Kusumoto K, Takaku F, Miura Y (1982) Granulocyte-macrophage colony stimulating and binding activities of purified human urinary colony stimulating factor to murine and human bone marrow cells. Blood 60: 1378–1386.

    PubMed  CAS  Google Scholar 

  • Mufson RA, Aghajanian T, Wong G, Woodhouse C, Morgan AL (1989) Macrophage colony stimulating factor enhances monocyte and macrophage antibody-dependent cell-mediated cytotoxicity. Cell Immunol 119: 182–192.

    PubMed  CAS  Google Scholar 

  • Muller R, Slamon DJ, Adamson ED, Tremblay JM, Muller D, Cline MJ, Verma IM (1983) Transcription of c-onc genes c-ras Ki and c-fms during mouse development. Mol Cell Biol 3: 1062–1069.

    PubMed  CAS  Google Scholar 

  • Munn DH, Garnick MB, Cheung NKV (1988) Effects of parenteral macrophage colony stimulating factor (M-CSF) on circulating monocyte number, immunophenotype and anti-tumor activity in cynomolgus monkeys. Blood 72: 127a.

    Google Scholar 

  • Munn DH, Garnick MB, Cheung NV (1990) Effects of parenteral recombinant human macrophage colony stimulating factor on monocyte number, phenotype and antitumor cytotoxicity in non-human primates. Blood 75: 2042–2048.

    PubMed  CAS  Google Scholar 

  • Nakamura M, Merchau S, Carter A, Ernst TJ, Demetri GD, Furukawa Y, Anderson W, Freedman AS, Griffin JD (1989) Expression of a novel 3.5kb macrophage colony stimulating factor transcript in human myeloma cells. J Immunol 143: 3543–3547.

    PubMed  CAS  Google Scholar 

  • Nakoinz I, Ralph P (1988) Stimulation of macrophage antibody-dependent killing of tumor targets by recombinant lymphokine factors and M-CSF. Cell Immunol 116: 331–340.

    PubMed  CAS  Google Scholar 

  • Ohtsuka M, Roussel MF, Sherr CJ, Downing JR (1990) Ligand-induced phosphorylation of the colony stimulating factor-1 receptor can occur through an intermoiecular reaction that triggers receptor downmodulation. Mol Cell Biol 10: 1664–1671.

    PubMed  CAS  Google Scholar 

  • Orlandi M, Barbolini G, Minghetti L, Luchetti S, Giuliucci B, Chiricolo M, Tomasi V (1989) Prostaglandin and thromboxane biosynthesis in isolated platelet-free human monocytes. III. The induction of cyclo-oxygenase by colony stimulating factor-1. Prostaglandins, Leukotrienes and Essential Fatty Acids 36: 101–106.

    CAS  Google Scholar 

  • Orlofsky A, Stanley ER (1987) CSF-1-induced gene expression in macrophages; dissociation from the mitogenic response. EMBO J 6: 2947–2952.

    PubMed  CAS  Google Scholar 

  • Oster W, Lindemann A, Mertelsmann R, Herrmann F (1989) Production of macrophage-, granulocyte-, granulocyte-macrophage-and multi-colony-stimulating factor by peripheral blood cells. Eur J Immunol 19: 543–547.

    PubMed  CAS  Google Scholar 

  • Paietta E, Racevsbis J, Stanley ER, Andreef M, Papenhausen P, Wiernik PH (1990) Expression of the macrophage growth factor CSF-1 and its receptor c-fms by a Hodgkin’s disease-derived cell line and its variants. Cancer Res 50: 2049–2055.

    PubMed  CAS  Google Scholar 

  • Pettenati MJ, LeBeau MM, Lemons RS et al. (1987) Assignment of CSF-1 to 5q 33.1: evidence for clustering of genes regulating hematopoiesis and for their involvement in the deletion of the long arm of chromosome 5 in myeloid disorders. Proc Natl Acad Sci USA 84: 2970–2974.

    PubMed  CAS  Google Scholar 

  • Pluznik DH, Sachs L (1965) The cloning of normal “mast” cells in tissue culture. J Cell Comp Physiol 66: 319–324.

    CAS  Google Scholar 

  • Pollard JW, Bartocci A, Arceci R, Orlofsky A, Ladner MB, Stanley ER (1987) Apparent role of the macrophage growth factor, CSF-1, in placental development. Nature 330: 484–486.

    PubMed  CAS  Google Scholar 

  • Rajavashisth TB, Eng R, Shadduck RK, Waheed A, Ben-Avram CM, Shively JE, Lusis AJ (1987) Cloning and tissue specific of mouse macrophage colony stimulating factor mRNA. Proc Natl Acad Sci USA 84: 1157–1161.

    PubMed  CAS  Google Scholar 

  • Ralph P, Nakoinz I (1987) Stimulation of macrophage tumoricidal activity by CSF-1. Cell Immunol 105: 270–279.

    PubMed  CAS  Google Scholar 

  • Ralph P, Warren MK (1989) Molecular biology, cell biology and clinical future in myeloid growth factors. In: Cruse JM, Lewis RE Jr (eds). Immunoregulatory cytokines and cell growth. Year Immunol, Karger, Basel, vol 5, pp 103–125.

    Google Scholar 

  • Ralph P, Warren MK, Nakoinz I et al. (1986a) Biological properties and molecular biology of the human macrophage growth factor, CSF-1. Immunobiology 172: 194–204.

    PubMed  CAS  Google Scholar 

  • Ralph P, Warren MK, Lee MT et al. (1986b) Inducible production of human macrophage growth factor, CSF-1. Blood 68: 633–639.

    PubMed  CAS  Google Scholar 

  • Rambaldi A, Young DC, Griffin JD (1987) Expression of the M-CSF (CSF-1) gene by human monocytes. Blood 69: 1409–1413.

    PubMed  CAS  Google Scholar 

  • Rambaldi A, Wakiyama N, Vellenger E, Horiguchi J, Warren MK, Kufe D, Griffin JD (1988) Expression of the macrophage colony-stimulating factor and c-fms genes in human acute myeloblastic leukemia cells. J Clin Invest 81: 1030–1035.

    PubMed  CAS  Google Scholar 

  • Regenstreif LJ, Rossant J (1989) Expression of the c-fms proto-oncogene and of the cytokine, CSF-1, during mouse embryogenesis. Dev Biol 133: 284–294.

    PubMed  CAS  Google Scholar 

  • Reisbach G, Sindermann J, Kremer JP, Hultner L, Wolf H, Dormer P (1989) Macrophage colony stimulating factor is expressed by spontaneously outgrown EBV-B cell lines and activated normal B lymphocytes. Blood 74: 959–964.

    PubMed  CAS  Google Scholar 

  • Rettenmier CW, Roussel MF (1988) Differential processing of colony stimulating factor-1 precursors encoded by two human cDNAs. Mol Cell Biol 8: 5026–5034.

    PubMed  CAS  Google Scholar 

  • Rettenmier CW, Sacca R, Furman WL et al. (1986) Expression of the human c-fms protooncogene product (colony stimulating factor-1 receptor) on peripheral blood mononuclear cells and choriocarcinoma cell lines. J Clin Invest 77: 1740–1746.

    PubMed  CAS  Google Scholar 

  • Rettenmier CW, Roussel MF, Ashmun RA, Ralph P, Price K, Sherr CJ (1987) Synthesis of membrane bound colony-stimulating factor-1 (CSF-1) and down-modulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes. Mol Cell Biol 7: 2378–2387.

    PubMed  CAS  Google Scholar 

  • Rich A, Nordheim A, Wang A (1984) The chemistry and biology of left-handed Z-DNA. Annu Rev Biochem 53: 792–846.

    Google Scholar 

  • Roberts WM, Look AT, Roussel MF, Sherr CJ (1988) Tandem linkage of human CSF-1 receptor (c-fms) and PDGF receptor genes. Cell 55: 655–661.

    PubMed  CAS  Google Scholar 

  • Rosendaal M (1975) Colony stimulating factor (CSF) in the uterus of the pregnant mouse. J Cell Sci 19: 411–423.

    PubMed  CAS  Google Scholar 

  • Roth P (1990) Human colony stimulating factor-1 is elevated in the fetus and newborn. Clin Res 38: 772A.

    Google Scholar 

  • Roth P, Bartocci A, Stanley ER (1990) Lipopolysaccharide induces synthesis of murine colony stimulating factor-1 (CSF-1) in vivo. Ped Res 27: 49A.

    Google Scholar 

  • Rothwell VM, Rohrschneider LR (1987) Murine c-fms cDNA: cloning, sequence analysis, and retroviral expression. Oncogene Res 1: 311–324.

    PubMed  CAS  Google Scholar 

  • Roussel MF, Sherr CJ, Barker PE, Ruddle FH (1983) Molecular cloning of the c-fms locus and its assignment to human chromosome 5. J Virol 48: 770–773.

    PubMed  CAS  Google Scholar 

  • Roussel MF, Dull TJ, Rettenmier CW, Ralph P, Ullrich A, Sherr CJ (1987) Transforming potential of the c-fms protooncogene (CSF-1 receptor). Nature 325: 549–552.

    PubMed  CAS  Google Scholar 

  • Roussel MF, Downing JR, Rettenmier CW, Sherr CJ (1988) A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms) proto-oncogene product) activates its transforming potential. Cell 55: 979–988.

    PubMed  CAS  Google Scholar 

  • Roussel MF, Shurtleff S, Downing JR, Sherr CJ (1990) A point mutation at tyrosine-809 in the human colony stimulating factor-1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol-3-kinase, or induction of c-fos and jun B genes. Proc Natl Acad Sci USA 87: 6738–6742.

    PubMed  CAS  Google Scholar 

  • Sampson-Johannes A, Carlino JA (1988) Enhancement of human monocyte tumoricidal activity by recombinant M-CSF. J Immunol 141: 3680–3686.

    PubMed  CAS  Google Scholar 

  • Sariban E, Mitchell T, Kufe D (1985) Expression of the c-fms protooncogene during human monocytic differentiation. Nature 316: 64–66.

    PubMed  CAS  Google Scholar 

  • Sawada M, Suzumura A, Yamamoto H, Marunouchi T (1990) Activation and proliferation of the isolated microglia by CSF-1 and possible involvement of protein kinase C. Brain Res 509: 119–124.

    PubMed  CAS  Google Scholar 

  • Seelentag WK, Mermod JJ, Montesano R, Vassalli P (1987) Additive effects of interleukin-1 and tumor necrosis factor-alpha on the accumulation of the three granulocyte and macrophage colony-stimulating factor mRNAs in human endothelial cells. EMBO J 6: 2261–2265.

    PubMed  CAS  Google Scholar 

  • Sengupta A, Liu WK, Yeung YG, Yeung DCY, Frackelton AR, Stanley ER (1988) Identification and subcellular localization of proteins that are rapidly phosphorylated in tyrosine in response to colony stimulating factor-1. Proc Natl Acad Sci USA 85: 8062–8066.

    PubMed  CAS  Google Scholar 

  • Shaw G, Kamen R (1986) A conserved AU sequence from the 3′-untranslated region of GM-CSF mRNA mediates selective degradation. Cell 46: 659–667.

    PubMed  CAS  Google Scholar 

  • Sherr CJ (1990) Colony stimulating factor-1 receptor. Blood 75: 1–12.

    PubMed  CAS  Google Scholar 

  • Sherr CJ, Stanley ER (1990) Colony stimulating factor-1. In: Sporn MB, Roberts AB (eds) Peptide growth factors and their receptors. Springer, Berlin Heidelberg New York, pp 667–698.

    Google Scholar 

  • Sherr CJ, Rettenmier CW, Sacca R, Roussel MF, Look AT, Stanley ER (1985) The c-fms protooncogene product is related to the receptor for the mononuclear phagocyte growth factor CSF-1. Cell 41: 665–676.

    PubMed  CAS  Google Scholar 

  • Shieh JH, Peterson RHF, Warren DJ, Moore MAS (1989) Modulation of colony stimulating factor-1 receptors on macrophages by tumor necrosis factor. J Immunol 143: 2534–2539.

    PubMed  CAS  Google Scholar 

  • Shimano H, Yamada N, Motoyoshi K, Matsumoto A, Ishibashi S, Mori N, Takaku F (1990) Plasma cholesterol-lowering activity of monocyte colony stimulating factor (M-CSF). Ann NY Acad Sci 587: 362–370.

    PubMed  CAS  Google Scholar 

  • Shurtleff SA, Downing JR, Rock CO, Hawkins SA, Roussel MF, Sherr CJ (1990) Structural features of the colony stimulating factor-1 receptor that affect its association with phosphatidylinositol-3-kinase. EMBO J 9: 2415–2421.

    PubMed  CAS  Google Scholar 

  • Stanley ER (1990) Role of colony stimulating factor-1 in monocytopoiesis and placental development. In: Mahowald A (ed) Genetics of pattern formation and growth control. Wiley-Liss, New York, pp 165–180.

    Google Scholar 

  • Stanley ER, Guilbert LJ (1981) Methods for the purification, assay, characterization and target cell binding of a colony stimulating factor (CSF-1). J Immunol Methods 42: 253–284.

    PubMed  CAS  Google Scholar 

  • Stanley ER, Heard PM (1977) Factors regulating macrophage production and growth. Purification and some properties of the colony stimulating factor from medium conditioned by mouse L-cells. J Biol Chem 252: 4305–4312.

    PubMed  CAS  Google Scholar 

  • Stanley ER, Jubinsky PT (1984) Factors affecting growth and differentiation of hematopoietic cells in culture. Clin Haematol 13: 329–336.

    PubMed  CAS  Google Scholar 

  • Stanley ER, Cifone M, Heard PM, Defendi V (1976) Factors regulating macrophage production and growth: identity of colony stimulating factor and macrophage growth factor. J Exp Med 143: 631–646.

    PubMed  CAS  Google Scholar 

  • Stanley ER, Chen DM, Lin HS (1978) Induction of macrophage production and proliferation by a purified colony stimulating factor. Nature 274: 168–170.

    PubMed  CAS  Google Scholar 

  • Stanley ER, Guilbert LJ, Tushinski RJ, Bartelmez SH (1983) CSF-1: a mononuclear phagocyte lineage-specific growth factor. J Cell Biochem 21: 151–159.

    PubMed  CAS  Google Scholar 

  • Stein J, Borzillo GV, Rettenmier CW (1990) Direct stimulation of cells expressing receptors for macrophage colony stimulating factor (CSF-1) by a plasma membrane-bound precursor of human CSF-1. Blood 76: 1308–1314.

    PubMed  CAS  Google Scholar 

  • Sutherland GR, Baker E, Callen DJ et al. (1988) Interleukin-5 is at 5q 31 and is deleted in the 5q-syndrome. Blood 71: 1150–1152.

    PubMed  CAS  Google Scholar 

  • Takahashi M, Hong YM, Yasuda S, Takano M, Kawai K, Nakai S, Hirai Y (1988) Macrophage colony stimulating factor is produced by human T lymphoblastoid cell line, CEM-ON: identification by aminoterminal amino acid sequence analysis. Biochem Biophys Res Commun 152: 1401–1409.

    PubMed  CAS  Google Scholar 

  • Thery C, Hetier E, Evrard C, Mallat M (1990) Expression of macrophage colony-stimulating factor gene in mouse brain during development. J Neurosci Res 26: 129–133.

    PubMed  CAS  Google Scholar 

  • Tushinski RJ, Stanley ER (1985) The regulation of mononuclear phagocyte entry into S phase by the colony stimulating factor CSF-1. J Cell Physiol 122: 221–228.

    PubMed  CAS  Google Scholar 

  • Tushinski RJ, Oliver IT, Guilbert LJ, Tynan PW, Warner JR, Stanley ER (1982) Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy. Cell 28: 71–81.

    PubMed  CAS  Google Scholar 

  • Vairo G, Hamilton JA (1988) Activation and proliferation signals in murine macrophages: stimulation of Na+/k+ ATPase activity by hematopoietic growth factors and other agents. J Cell Physiol 134: 13–24.

    PubMed  CAS  Google Scholar 

  • Van Leeuwen BH, Martinson ME, Webb GC, Young IG (1989) Molecular organization of the cytokine gene cluster, involving human IL-3, IL-4, IL-5 and GM-CSF genes, on human chromosome 5. Blood 73: 1142–1148.

    PubMed  Google Scholar 

  • Varticovski L, Druker B, Morrison D, Cantley L, Roberts T (1989) The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase. Nature 342: 699–702.

    PubMed  CAS  Google Scholar 

  • Visvader J, Verma IM (1989) Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes. Mol Cell Biol 9: 1336–1341.

    PubMed  CAS  Google Scholar 

  • Waheed A, Shadduck RK (1982) Purification of colony stimulating factor by affinity chromotography. Blood 60: 238–244.

    PubMed  CAS  Google Scholar 

  • Wakamiya N, Horiguchi J, Kufe D (1987) Detection of c-fms and CSF-1 RNA by in situ hybridization. Leukemia 1: 518–520.

    PubMed  CAS  Google Scholar 

  • Walker F, Nicola NA, Metcalf D, Burgess AW (1985) Hierarchical down-modulation of hemopoietic growth factor receptors. Cell 43: 269–276.

    PubMed  CAS  Google Scholar 

  • Wang C, Kelleher CA, Cheng GYM et al. (1988) Expression of the CSF-1 gene in the blast cells of acute myeloblastic leukemia: association with reduced growth capacity. J Cell Physiol 135: 133–138.

    PubMed  CAS  Google Scholar 

  • Wang FM, Friedman H, Djen J (1989) Enhancement of human monocyte action against Candida albicans by colony stimulating factors (CSF): IL-3, granulocyte-macrophage CSF and macrophage CSF. J Immunol 143: 671–677.

    PubMed  CAS  Google Scholar 

  • Wang JM, Griffin JD, Rambaldi A, Chen ZG, Mantovani A (1988) Induction of monocyte migration by recombinant macrophage colony stimulating factor. J Immunol 141: 575–579.

    PubMed  CAS  Google Scholar 

  • Warren D, Moore MAS (1987) Synergy of interleukin-1 and granulocyte stimulating factor: in vivo stimulation of stem cell recovery and hematopoietic regeneration following 5-fluorouracil treatment of mice. Proc Natl Acad Sci USA 84: 7134–7138.

    PubMed  Google Scholar 

  • Warren MK, Ralph P (1986) Macrophage growth factor CSF-1 stimulates human monocyte production of interferon, tumor necrosis factor and colony stimulating activity. J Immunol 137: 2281–2285.

    PubMed  CAS  Google Scholar 

  • Weber B, Horiguchi J, Luebbers R, Sherman M, Kufe D (1989) Post-translational stabilization of c-fms mRNA by a labile protein during human monocyte differentiation. Mol Cell Biol 9: 769–775.

    PubMed  CAS  Google Scholar 

  • Wheeler EF, Rettenmier CW, Look AT, Sherr CJ (1986) The v-fms oncogene induces factor independence and tumorigenicity in CSF-1 dependent macrophage cell line. Nature 324: 377–380.

    PubMed  CAS  Google Scholar 

  • Wiktor-Jedrzejczak W, Bartocci A, Ferrante AW, Ahmed-Ansari A, Sell KW, Pollard JW, Stanley ER (1990) Total absence of colony stimulating factor-1 in the macrophage deficient osteopetrotic (op/op) mouse. Proc Natl Acad Sci USA 87: 4828–4832.

    PubMed  CAS  Google Scholar 

  • Williams DE, Stranera JE, Cooper S et al. (1987) Interactions between purified murine colony stimulating factors (natural CSF-1, purified recombinant GM-CSF and purified recombinant IL-3) on the in vitro proliferation of purified murine granulocyte-macrophage progenitor cells. Exp Hematol 15: 1007–1012.

    PubMed  CAS  Google Scholar 

  • Williams DE, Eisenman J, Baird A et al. (1990) Identification of a ligand for the c-kit proto-oncogene. Cell 63: 167–174.

    PubMed  CAS  Google Scholar 

  • Willman CL, Stewart CC, Miller V, Yi TL, Tomasi TB (1989) Regulation of MHC class II gene expression in macrophages by hematopoietic colony stimulating factors (CSF). Induction by GM-CSF and inhibition by CSF-1. J Exp Med 170: 1559–1567.

    PubMed  CAS  Google Scholar 

  • Wing EJ, Magee DM, Pearson AC, Waheed A, Shadduck RK (1986) Peritoneal macrophages exposed to purified macrophage-colony stimulating factor (M-CSF) suppress mitogen-and antigen-stimulated lymphocyte proliferation. J Immunol 137: 2768–2773.

    PubMed  CAS  Google Scholar 

  • Wong GG, Temple PA, Leary AC et al. (1987) Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein. Science 235: 1504–1508.

    PubMed  CAS  Google Scholar 

  • Woolford J, McAuliffe A, Rohrschneider LR (1988) Activation of the feline c-fms protooncogene: multiple alterations are required to generate a fully transformed phenotype. Cell 55: 965–977.

    PubMed  CAS  Google Scholar 

  • Yan ZJ, Wang QR, McNiece IK, Wolf NS (1990) Dissecting the hematopoietic microenvironment. VII. The production of an autostimulatory factor as well as a CSF by unstimulated murine marrow fibroblasts. Exp Hematol 18: 348–354.

    PubMed  CAS  Google Scholar 

  • Yang YC, Kovacic S, Kriz R et al. (1988) The human genes for GM-CSF and IL-3 are closely linked in tandem on chromosome 5. Blood 71: 958–961.

    PubMed  CAS  Google Scholar 

  • Yarden Y, Escobedo JA, Kuang WJ et al. (1986) Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature 323: 226–232.

    PubMed  CAS  Google Scholar 

  • Yarden Y, Kuang WJ, Yuang-Feng T et al. (1987) Human protooncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 6: 3341–3351.

    PubMed  CAS  Google Scholar 

  • Yeung YG, Jubinsky PT, Sengupta A, Yeung DCY, Stanley ER (1987) Purification of the colony stimulating factor-1 receptor and demonstration of its tyrosine kinase activity. Proc Natl Acad Sci USA 84: 1268–1271.

    PubMed  CAS  Google Scholar 

  • Zsebo KM, Wypych J, Yuschenkoff VN, Lu H, Hunt P, Dukes PP, Langley KE (1988) Effects of hemopoietin-1 and interleukin-1 activities on early hematopoietic cells of the bone marrow. Blood 71: 962–968.

    PubMed  CAS  Google Scholar 

  • Zsebo KM, Williams DA, Geissler EN et al. (1990) Stem cell factor is encoded at the S1 locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell 63: 213–224.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA

    P. Roth

  2. Departments of Developmental Biology and Cancer, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA

    E. R. Stanley

Authors
  1. P. Roth
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. R. Stanley
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Kansas Cancer Ctr., Kansas City, KA, 66160-7312, USA

    Stephen W. Russell (Wilkinson Distinguished Professor and Director) (Wilkinson Distinguished Professor and Director)

  2. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK

    Siamon Gordon

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Roth, P., Stanley, E.R. (1992). The Biology of CSF-1 and Its Receptor. In: Russell, S.W., Gordon, S. (eds) Macrophage Biology and Activation. Current Topics in Microbiology and Immunology, vol 181. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77377-8_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-77377-8_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77379-2

  • Online ISBN: 978-3-642-77377-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation