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Comparative Genomics: An Introduction: Sequencing Projects and Model Organisms

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Comparative Genomics

Abstract

At its most literal the term means comparing genomes. This immediately brings to mind DNA and protein sequences and inevitably comparison with the human genome. However, Comparative genomics is more than that. It applies to the comparison of any organism at a variety of levels: DNA or protein sequences, mapping positions and maps, function and evolution. The aim is to decipher how genes function and provide an understanding of the link between genotype and phenotype. Often this is with particular reference to a set of heritable characters or disease, as these are clearly more attractive funding possibilities (even more so when human studies enter into the experimental equation). With livestock, such as cattle, sheep, pigs, fish etc, which are of great economic importance to any country, there are clear commercial requirements to being able to understand the inheritance patterns of advantageous characters and also disease. However, any commercial applications are underpinned by a vast array of academic or “basic” research.

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  1. Fugu Genomics HGMP Resource Centre, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SB, UK

    Melody S. Clark

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  1. Fugu Genomics HGMP Resource Centre, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SB, UK

    Melody S. Clark

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Clark, M.S. (2000). Comparative Genomics: An Introduction: Sequencing Projects and Model Organisms. In: Clark, M.S. (eds) Comparative Genomics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4657-3_1

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  • DOI: https://doi.org/10.1007/978-1-4615-4657-3_1

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