Pathology of Soft Tissue Sarcomas
The information derived from the pathological study of tissue is central to the management of patients presenting with soft tissue lesions. The histological diagnosis can be derived from good sections obtained from an excision or an incisional biopsy. A clinical history and knowledge of the radiological and clinical findings are helpful and sometimes essential. A fine needle aspiration (FNA) is an efficient way to orient the diagnosis (e.g., lymphoma vs. mesenchymal lesion) and a good approach to the planning of diagnostic surgery. FNA is also a good technique to establish the diagnosis of recurrent disease. However, accurate histological typing and grading of most lesions require a detailed and generous sampling of the entire lesion. Whenever possible, tissue should be put aside for electron microscopy and immunohistochemistry on frozen sections.
KeywordsSoft Tissue Sarcoma Synovial Sarcoma Soft Tissue Tumor Malignant Fibrous Histiocytoma Clear Cell Sarcoma
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- 11.Brooks JJ: Seminar on soft tissue pathology. European Society of Pathology, Porto, 1989.Google Scholar
- 12.Lambe CDK, Cartun RW, Knibbs DR, et al.: Immunocytochemical reactivity with cytokeratin monoclonal antibodies in malignant melanoma. Further evidence dictating cautious interpretation of immunostaining. Lab Invest 60:50a, 1989.Google Scholar
- 14.Zarbo RJ, Raju U, Regezi J, et al.: Melanotic neuroectodermal tumors (MNT) of infancy: Intermediate filament, neuroendocrine and melanoma associated antigen profile. Lab Invest 60:109a, 1989.Google Scholar
- 16.Chen J, Jones PA: Conversion of human osteogenic sarcoma cells into contractile myotubes by a muscle determination gene. Proc Am Assoc Cancer Res 30 (Abstr.):42, 1989.Google Scholar
- 18.Evans HL: Liposarcoma. A study of 55 cases with reassessment of its classification. Am J Surg Pathol 3:507, 1979.Google Scholar
- 31.Turc-Carel C, Dal Cin P, Limon J, et al.: Translocation X:18 in synovial sarcoma. Cancer Genet Cytogenet 23:93, 1986.Google Scholar
- 33.Scrable HJ, Lamplin BC, Witte OP, et al.: Mitotic recombination mapping localizes the human rhabdomyosarcoma locus to chromosome l1p 15.5 llpter. Nature 329:645–647, 1987.Google Scholar