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Part of the book series: Cancer Treatment and Research ((CTAR,volume 56))

Abstract

The information derived from the pathological study of tissue is central to the management of patients presenting with soft tissue lesions. The histological diagnosis can be derived from good sections obtained from an excision or an incisional biopsy. A clinical history and knowledge of the radiological and clinical findings are helpful and sometimes essential. A fine needle aspiration (FNA) is an efficient way to orient the diagnosis (e.g., lymphoma vs. mesenchymal lesion) and a good approach to the planning of diagnostic surgery. FNA is also a good technique to establish the diagnosis of recurrent disease. However, accurate histological typing and grading of most lesions require a detailed and generous sampling of the entire lesion. Whenever possible, tissue should be put aside for electron microscopy and immunohistochemistry on frozen sections.

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References

  1. Shmookler BM, Enzinger FM, Weiss SW: Giant cell fibroblastoma. A juvenile form of dermatofibrosarcoma protuberans. Cancer 64:2154–2161, 1989.

    Article  PubMed  CAS  Google Scholar 

  2. Suster S, Rosai J: Intranodal hemorrhagic spindle-cell tumor with “amianthoid” fibers. Report of six cases of a distinctive mesenchymal neoplasm of the inguinal region that simulates Kaposi’s sarcoma. Am J Surg Pathol 13:347–357, 1989.

    Article  PubMed  CAS  Google Scholar 

  3. Weiss SW, Gnepp DR, Bratthauer GL: Palisaded myofibroblastoma. A benign mesenchymal tumor of lymph node. Am J Surg Pathol 13:341–346, 1989.

    Article  PubMed  CAS  Google Scholar 

  4. Walford N, Van Der Wouw PA, Das PK, Ten Velden JJAM, Hulsebosch HJ: Epithelioid angiomatosis in the acquired immunodeficiency syndrome: Morphology and differential diagnosis. Histopathology 16:83–88, 1990.

    Article  PubMed  CAS  Google Scholar 

  5. Brandwein M, Choi HSH, Strauchen J, Stoler M, Jagirdar J: Spindle cell reaction to nontuberculous mycobacteriosis in AIDS mimicking a spindle cell neoplasm. Virchows Arch [A] 416:281–286, 1990.

    Article  CAS  Google Scholar 

  6. Angervall L, Kindblom LG: The diagnosis of soft tissue tumors. The Göteborg experience. In: Recent concepts in sarcoma treatment. Ryan J, Bahn LO, (eds). Boston: Kluwer Academic Publishers, pp 22–26, 1988.

    Chapter  Google Scholar 

  7. Brooks JJ: Immunochemistry in sarcomas. In: Recent concepts in sarcoma treatment. Ryan J, Bahn LO, (eds). Boston: Kluwer Academic Publishers, pp 48–55, 1988.

    Chapter  Google Scholar 

  8. Miettinen M: Immunoreactivity for cytokeratin and epithelial membrane antigen in leiomyosarcoma. Arch Pathol Lab Med 112:637–640, 1988.

    PubMed  CAS  Google Scholar 

  9. Weiss SW, Brathauer GL, Morris PA: Postirradiation malignant fibrous histiocytoma expressing cytokeratin. Am J Surg Pathol 12:554–558, 1988.

    Article  PubMed  CAS  Google Scholar 

  10. Miettinen M, Rapola J: Immunohistochemical spectrum of rhabdomyosarcoma and rhabdomyosarcoma-like tumors. Expression of cytokeratin and the 68 kd neurofilament protein. Am J Surg Pathol 13:120–132, 1989.

    Article  PubMed  CAS  Google Scholar 

  11. Brooks JJ: Seminar on soft tissue pathology. European Society of Pathology, Porto, 1989.

    Google Scholar 

  12. Lambe CDK, Cartun RW, Knibbs DR, et al.: Immunocytochemical reactivity with cytokeratin monoclonal antibodies in malignant melanoma. Further evidence dictating cautious interpretation of immunostaining. Lab Invest 60:50a, 1989.

    Google Scholar 

  13. Costrove M, Fitzgibbons PL, Sherrod A, et al.: Intermediate filament expression in astro-cytic neoplasms. Am J Surg Pathol 13:141–145, 1989.

    Article  Google Scholar 

  14. Zarbo RJ, Raju U, Regezi J, et al.: Melanotic neuroectodermal tumors (MNT) of infancy: Intermediate filament, neuroendocrine and melanoma associated antigen profile. Lab Invest 60:109a, 1989.

    Google Scholar 

  15. Gerald W, Rosai J: Desmoplastic small cell tumor with divergent differentiation. Ped Pathol 9:177–183, 1989.

    Article  CAS  Google Scholar 

  16. Chen J, Jones PA: Conversion of human osteogenic sarcoma cells into contractile myotubes by a muscle determination gene. Proc Am Assoc Cancer Res 30 (Abstr.):42, 1989.

    Google Scholar 

  17. Roberts WM, Douglas EC, Peiper S, et al.: Amplification of the gli gene in childhood sarcomas. Cancer Res 49:5407–5413, 1989.

    PubMed  CAS  Google Scholar 

  18. Evans HL: Liposarcoma. A study of 55 cases with reassessment of its classification. Am J Surg Pathol 3:507, 1979.

    Google Scholar 

  19. Friend SH, Horowitz JM, Gerber M, et al.: Deletions of DNA sequence in retinoblastoma and mesenchymal tumors: Organization and sequence of the encoded protein. Proc Natl Acad Sci USA 84:9059–9063, 1987.

    Article  PubMed  CAS  Google Scholar 

  20. Chen H, Miller C, Koeffer HP, et al.: Rearrangement of the p 53 gene in human osteogenic sarcomas. Proc Natl Acad Sci USA 84:7716–7719, 1987. Perosio MP, Brooks JJ: Expression of growth factors and growth factor receptors in soft tissue tumors. Lab Invest 60:24-253, 1989.

    Article  Google Scholar 

  21. Markhede G, Angervall L, Stener B: A multivariate analysis of the prognosis after surgical treatment of malignant soft tissue tumors. Cancer 49:1721–1723, 1982.

    Article  PubMed  CAS  Google Scholar 

  22. Trojani M, Contesso G, Coindre JM, et al.: Soft tissue sarcoma of the adults: Study of pathological prognostic variables and definition of histopathological grading system. Int J Cancer 33:37–42, 1983.

    Article  Google Scholar 

  23. Mandard AM, Petiot J, Marnay J, et al.: Prognostic factors in soft tissue sarcomas. A multivariate analysis (109 cases). Cancer 63:1437–1451, 1989.

    PubMed  CAS  Google Scholar 

  24. Costa J, Wesley RA, Glatstein E, et al.: The grading of soft tissue sarcomas: Results of a clinico-histopathological correlation in a series of 163 cases. Cancer 53:530–541, 1984.

    Article  PubMed  CAS  Google Scholar 

  25. Leyvraz S, Costa J: Histological diagnosis and grading of soft tissue sarcomas. Semin Surg Oncol 4:3–6, 1988.

    Article  PubMed  CAS  Google Scholar 

  26. Kreicbergs A, Tribukait B, Willems J, et al.: DNA flow analysis of soft tissue tumors. Cancer 59:128–133, 1987.

    Article  PubMed  CAS  Google Scholar 

  27. Schmidt D, Leuschner I, Harms D, et al.: Malignant rhabdoid tumor. A morphological and flow cytometric study. Pathol Res Pract 184:202–210, 1989.

    Article  PubMed  CAS  Google Scholar 

  28. Radio SJ, Wooldridge I, Linder J: Flow cytometry DNA analysis of malignant fibrous histiocytoma and related fibrohistiocytic tumors. Human Pathol 19:74–77, 1988.

    Article  CAS  Google Scholar 

  29. Zeppa P, Zabatta A, Marino G, et al.: A morphometric approach to the grading of chondroid tumors on fine-needle smears. Pathol Res Pract 185:760–763, 1989.

    Article  PubMed  CAS  Google Scholar 

  30. Turc-Carel C, Lizard-Nacol S, Justrabo E, et al.: Two new cases of primary peripheral neuroepithelioma of soft tissue with translocation T (11;22) (Q24;Q12). Cancer genet Cytogenet 33:291–297, 1988.

    Article  Google Scholar 

  31. Turc-Carel C, Dal Cin P, Limon J, et al.: Translocation X:18 in synovial sarcoma. Cancer Genet Cytogenet 23:93, 1986.

    Google Scholar 

  32. Turc-Carel C. Lizard-Nacol S, Justrabo E, et al.: Consistant chromosome translocation in alveolar rhabdomyosarcoma. Cancer Genet Cytogenet 19:361–362, 1986.

    Article  PubMed  CAS  Google Scholar 

  33. Scrable HJ, Lamplin BC, Witte OP, et al.: Mitotic recombination mapping localizes the human rhabdomyosarcoma locus to chromosome l1p 15.5 llpter. Nature 329:645–647, 1987.

    CAS  Google Scholar 

  34. Turc-Carel C, Limon J, Dal Cin P, et al.: Cytogenetic studies of adipous tissue tumors. Cancer Genet Cytogenet 23:291–299, 1986.

    Article  PubMed  CAS  Google Scholar 

  35. Mandahl N, Heim S, Arheden K, et al.: Three major cytogenetic subgroups can be identified among chromosomally abnormal solitary lipomas. Human Genet 79:203–208, 1988.

    Article  CAS  Google Scholar 

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© 1991 Springer Science+Business Media New York

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Costa, J., Guillou, L. (1991). Pathology of Soft Tissue Sarcomas. In: Pinedo, H.M., Verweij, J., Suit, H.D. (eds) Soft Tissue Sarcomas: New Developments in the Multidisciplinary Approach to Treatment. Cancer Treatment and Research, vol 56. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3896-7_1

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  • DOI: https://doi.org/10.1007/978-1-4615-3896-7_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6738-3

  • Online ISBN: 978-1-4615-3896-7

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