Abstract
Our laboratory is studying the spectrum of ionic and biochemical events which are activated seconds to minutes after the addition of mitogens to quiescent fibroblasts. Previous work determined serum and bradykinin to rapidly stimulate phospholipases A2 and C in human fibroblasts (1–4). Activation of these phospholipases results in the production of a variety of lipid-derived “second messengers” (including arachidonate and its metabolites, diacylglycerol and inositol trisphosphate). These messengers stimulate a variety of cellular processes which are thought to be important components of the mitogenic response — including changes in cellular ion fluxes (2–8), activation of protein kinases (7,8), and induction of rapid transcriptional events (9,10).
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Literature Cited
Jamieson, G.A., Jr. and Villereal, M.L.: Arch. Biochem. Biophys. 252:478, 1987.
Muldoon, L.L., Jamieson, G.A., Jr. and Villereal, M.L.: J. Cell Physiol. 130:29, 1987.
Jamieson, G.A., Jr., Etscheid, B.G., Muldoon, L.L. and Villereal, M.L.: J. Cell Physiol. 134:220, 1987.
Vicentini, L.M., Miller, R.J. and Villereal, M.L.: J. Biol. Chem. 259:6912, 1984.
Mix, L.L., Dinerstein, R.J. and Villereal, M.L.: Biochem. Biophys. Res. Comm. 119:69, 1984.
Muldoon, L.L., Dinerstein, R.J. and Villereal, M.L.: Am. J. Physiol. 294:C140, 1985.
Palfrey, H.C., Nairn, A.C., Muldoon, L.L. and Villereal, M.L.: J. Biol. Chem. 262:9785, 1987.
Muldoon, L.L., Jamieson, G.A., Jr., Kao, A.C., Palfrey, H.C. and Villereal, M.L.: Am. J. Physiol. 253 (Cell Physiol 22):C219, 1987.
Joseph, L.J., Le-Beau, M.M., Jamieson, G.A., Jr., Acharya, S., Shows, T.B., Rowley, J.D., and Sukhatme, V.P.: Proc. Natl. Acad. Sci. USA 85:7164, 1988.
Jamieson, G.A., Jr., Mayforth, R., Villereal, M.L.: J. Cell Physiol. 139:262, 1989.
Etscheid, B.G., Jamieson, G.A., Jr., Toscas, K. and Villereal, M.L.: Am. J. Physiol. 259:C549–556, 1990.
Parries, G., Hoebel, R. and Racker, E.: Proc. Natl. Acad. Sci. (USA) 84:2648, 1987.
Downward, J., de-Gunzburg, J., Riehl, R. and Weinberg, R.A.: Proc. Natl. Acad. Sci. USA 85:5774, 1988.
Ruggiero, M., Srivastava, S.K., Fleming, T.P., Ron, D., and Eva, A.: Oncogene 4:767, 1989.
Jamieson, G.A., Jr., Sukhatme, V.P., McArdle, R.A. and Villereal, M.L.: J. Cell Biol. 105:108a, 1987.
Powell, W.S.: Methods of Enzymology 86:467, 1982.
Bligh, E.G., Dyer, W.J.: Canad. J. Biochem. Physiol. 37:911, 1957.
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Jamieson, G.A., Flem, K.A., Elkousy, H.A., Holliday, S.A., Leikauf, G.D. (1991). Enhanced Eicosanoid Release in Ras-Transformed Cells. In: Honn, K.V., Marnett, L.J., Nigam, S., Walden, T.L. (eds) Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury. Developments in Oncology, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3874-5_45
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DOI: https://doi.org/10.1007/978-1-4615-3874-5_45
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