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Enhanced Eicosanoid Release in Ras-Transformed Cells

  • G. A. JamiesonJr.
  • K. A. Flem
  • H. A. Elkousy
  • S. A. Holliday
  • G. D. Leikauf
Chapter
Part of the Developments in Oncology book series (DION, volume 67)

Abstract

Our laboratory is studying the spectrum of ionic and biochemical events which are activated seconds to minutes after the addition of mitogens to quiescent fibroblasts. Previous work determined serum and bradykinin to rapidly stimulate phospholipases A2 and C in human fibroblasts (1–4). Activation of these phospholipases results in the production of a variety of lipid-derived “second messengers” (including arachidonate and its metabolites, diacylglycerol and inositol trisphosphate). These messengers stimulate a variety of cellular processes which are thought to be important components of the mitogenic response — including changes in cellular ion fluxes (2–8), activation of protein kinases (7,8), and induction of rapid transcriptional events (9,10).

Keywords

Inositol Phosphate Inositol Trisphosphate Bradykinin Receptor Arachidonate Metabolite Rodent Fibroblast 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • G. A. JamiesonJr.
    • 1
  • K. A. Flem
    • 1
  • H. A. Elkousy
    • 1
  • S. A. Holliday
    • 1
  • G. D. Leikauf
    • 1
  1. 1.Division of Molecular Toxicology, Department of Environmental HealthUniversity of Cincinnati College of MedicineCincinnatiUSA

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