Book Volume 67 1991

Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury

Proceedings of the 1st International Conference October 11–14, 1989 Detroit, Michigan USA

ISBN: 978-1-4613-6727-7 (Print) 978-1-4615-3874-5 (Online)

Table of contents (74 chapters)

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  1. Front Matter

    Pages i-xxxi

  2. Phospholipid Turnover Oxygenases and Fatty Acid Metabolism

    1. Front Matter

      Pages 1-1

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      Chapter

      Pages 3-8

      Immunobiochemical and Molecular Biological Studies on Arachidonate 12-Lipoxygenase of Porcine Leukocytes

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      Chapter

      Pages 9-14

      Transcellular Biosynthesis of Leukotrienes: Is Leukotriene A4 a Mediator?

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      Chapter

      Pages 15-18

      The Occurence of Thromboxane Synthase in Tumor Cells

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      Chapter

      Pages 19-25

      Stimulation and Inhibition of Oxygen Radical Formation by Ascorbic Acid and 13-CIS-Retinoic Acid

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      Chapter

      Pages 27-32

      Fatty Acid Cyclooxygenase Metabolism of Arachidonic Acid in Human Tumor Cells

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      Chapter

      Pages 33-36

      Identification of Linoleic Acid Metabolism as a Component of the Epidermal Growth Factor Signal Transduction Pathway in BALB/c 3T3 Fibroblasts

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      Chapter

      Pages 37-41

      Localization and Expression of the Eicosanoid Metabolizing P4501VA Gene Family in Rat Tissues and Hepatic Tumors

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      Chapter

      Pages 43-47

      Deficient Lipoxin Formation in Chronic Myelogenous Leukemia

  3. Radiation and Chemical Carcinogenesis

    1. Front Matter

      Pages 49-49

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      Chapter

      Pages 51-59

      Radiation Injury and Carcinogenesis

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      Chapter

      Pages 61-67

      Tumor Promotion and the Arachidonate Cascade

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      Chapter

      Pages 69-72

      Eicosanoids and Bioactive Lipids as Modifiers of Multistage Carcinogenesis In Vitro

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      Chapter

      Pages 73-77

      Prevention of Peroxide Produced DNA Strand Scission in Human Tumor Cells by Lipoxygenase Inhibitors

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      Chapter

      Pages 79-86

      8-Hydroxydeoxyguanosine, a DNA Adduct Formed by Oxygen Radicals: Its Implications on the Mutagenic and Carcinogenic Action of Oxygen Radical-Forming Agents

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      Chapter

      Pages 87-91

      Reaction of DNA Peroxyl Radicals with Cysteamine and Glutathione: The Formation of Sulfoxyl Radicals

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      Chapter

      Pages 93-102

      Fatty Acid-Induced Modulation of Carcinogenesis in Human and Mouse Mammary Explant Cultures

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      Chapter

      Pages 103-107

      Radiation Protection and Cancer Therapy by Linoleate

  4. Lipid Peroxidation, Eicosanoid Biosynthesis, and Radiation Induced Tissue Injury

    1. Front Matter

      Pages 109-109

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      Chapter

      Pages 111-115

      An Overview of Eicosanoid-Induced Radiation Protection

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      Chapter

      Pages 117-121

      Vascular Myointimal Proliferation

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      Chapter

      Pages 123-133

      Absence of Prostaglandin E2-Induced Radioprotection in Two Cell Lines Lacking Specific PGE2-Binding Sites

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      Chapter

      Pages 135-140

      Radiation-Induced Decrease in Rat Abdominal Aortic Reactivity to U46619: Amelioration with Indomethacin and WR2721

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