Abstract
Prostaglandin H synthase has two distinct catalytic activities: the cyclooxygenase activity generates a hydroperoxide PGG2, from arachidonic acid; the peroxidase activity reduces hydroperoxides to the corresponding alcohols like PGH2. The synthase is thus capable of both producing and destroying hydroperoxides. The metabolic progeny of PGH2 (prostaglandins, prostacyclins, thromboxanes) are known to affect many aspects of tumor growth and metastasis (reviewed in Ref. 1).
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Kulmacz, R.J. (1991). Initiation of the Cyclooxygenase Reaction via Peroxidase Enzyme Intermediates. In: Honn, K.V., Marnett, L.J., Nigam, S., Walden, T.L. (eds) Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury. Developments in Oncology, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3874-5_30
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DOI: https://doi.org/10.1007/978-1-4615-3874-5_30
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