Initiation of the Cyclooxygenase Reaction via Peroxidase Enzyme Intermediates

  • R. J. Kulmacz
Part of the Developments in Oncology book series (DION, volume 67)


Prostaglandin H synthase has two distinct catalytic activities: the cyclooxygenase activity generates a hydroperoxide PGG2, from arachidonic acid; the peroxidase activity reduces hydroperoxides to the corresponding alcohols like PGH2. The synthase is thus capable of both producing and destroying hydroperoxides. The metabolic progeny of PGH2 (prostaglandins, prostacyclins, thromboxanes) are known to affect many aspects of tumor growth and metastasis (reviewed in Ref. 1).


Peroxidase Activity Cyclooxygenase Activity Hydroperoxide Level Heme Prosthetic Group Cyclooxygenase Reaction 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • R. J. Kulmacz
    • 1
  1. 1.Dept. of Biological ChemistryUniv. of Illinois at ChicagoChicagoUSA

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