Initiation of the Cyclooxygenase Reaction via Peroxidase Enzyme Intermediates
Prostaglandin H synthase has two distinct catalytic activities: the cyclooxygenase activity generates a hydroperoxide PGG2, from arachidonic acid; the peroxidase activity reduces hydroperoxides to the corresponding alcohols like PGH2. The synthase is thus capable of both producing and destroying hydroperoxides. The metabolic progeny of PGH2 (prostaglandins, prostacyclins, thromboxanes) are known to affect many aspects of tumor growth and metastasis (reviewed in Ref. 1).
KeywordsPeroxidase Activity Cyclooxygenase Activity Hydroperoxide Level Heme Prosthetic Group Cyclooxygenase Reaction
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