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Thrombin-Stimulated Endothelial Cell Functions: Monocyte Adhesion and PDGF Production

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Atherosclerosis

Part of the book series: Altschul Symposia Series ((ALSS,volume 1))

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Abstract

In the past decade there has been much interest in the concept of an activated or injured endothelium that exhibits properties distinct from healthy, adult endothelium. The activated state of the endothelial cell may result from the action of cytokines, as recently reviewed in detail by Pober and Cotranl. Alternatively, injury to the endothelium may shorten endothelial cell lifetime, causing increased turnover in specific regions of the artery. This may, in turn, lead to the expression of genes which are suppressed under physiological rather than pathological conditions, even in the absence of exogenous stimulators. Extrapolation of in vitro findings has suggested to us a possible role of dysfunctional endothelium in the development of the atherosclerotic plaque2. Activated endothelial cells may (1) express binding sites for monocytes and perhaps secrete monocyte activators; (2) secrete oxygen free radicals that can modify nearby low density lipoprotein (LDL); (3) act as a procoagulant rather than an anticoagulant surface, and (4) synthesize and secrete a PDGF-like protein and/or other mitogens and chemoattractants for medial smooth muscle cells.

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Authors and Affiliations

  1. Department of Vascular Cell Biology and Atherosclerosis, Cleveland Clinic Research Institute, Cleveland, OH, 44195, USA

    Paul E. DiCorleto, Carol de la Motte & Ravi Shankar

Authors
  1. Paul E. DiCorleto
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  2. Carol de la Motte
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  3. Ravi Shankar
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Editor information

Editors and Affiliations

  1. University of Toronto, Toronto, Ontario, Canada

    Avrum I. Gotlieb  & B. Lowell Langille  & 

  2. University of Saskatchewan, Saskatoon, Saskatchewan, Canada

    Sergey Fedoroff

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© 1991 Springer Science+Business Media New York

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DiCorleto, P.E., de la Motte, C., Shankar, R. (1991). Thrombin-Stimulated Endothelial Cell Functions: Monocyte Adhesion and PDGF Production. In: Gotlieb, A.I., Langille, B.L., Fedoroff, S. (eds) Atherosclerosis. Altschul Symposia Series, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3754-0_7

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  • DOI: https://doi.org/10.1007/978-1-4615-3754-0_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6672-0

  • Online ISBN: 978-1-4615-3754-0

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