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Atherosclerosis

Cellular and Molecular Interactions in the Artery Wall

  • Avrum I. Gotlieb
  • B. Lowell Langille
  • Sergey Fedoroff

Part of the Altschul Symposia Series book series (ALSS, volume 1)

Table of contents

  1. Front Matter
    Pages i-x
  2. Rudolph Altschul: Man and Scientist

    1. S. Fedoroff
      Pages 1-4
  3. The Dynamic Vessel Wall

    1. Front Matter
      Pages 5-5
    2. Stephen M. Schwartz, David Gordon, Josiah N. Wilcox
      Pages 7-31
  4. Vascular Wall Injury and Repair

    1. Front Matter
      Pages 57-57
    2. Michael A. Reidy, Volkhard Lindner
      Pages 59-66
    3. Paul E. DiCorleto, Carol de la Motte, Ravi Shankar
      Pages 89-97
  5. Extracellular Matrix Interactions in Atherogenesis

  6. Autocrine and Paracrine Control of Vascular Tissue

    1. Front Matter
      Pages 137-137
    2. Tucker Collins, Regina Young, Arturo E. Mendoza, Jochen W. U. Fries, Amy J. Williams, Parvez Sultan et al.
      Pages 139-152
    3. Peter Libby, Harald Loppnow, James C. Fleet, Helen Palmer, Hong Mei Li, Stephen J. C. Warner et al.
      Pages 161-169
  7. Thrombosis and Fibrinolysis

    1. Front Matter
      Pages 171-171
    2. Satoshi Ogawa, Masayasu Matsumoto, Jerold Brett, Matthias Clauss, David M. Stern
      Pages 173-185
    3. Marian A. Packham
      Pages 209-225
    4. Michael R. Buchanan, Maria C. Bertomeu, Stephanie J. Brister, Thomas A. Haas
      Pages 227-233
  8. Lipids in Atherogenesis

    1. Front Matter
      Pages 235-235
    2. Wolfgang J. Schneider
      Pages 237-245
    3. Göran Bondjers, Eva Hurt Camejo, Olle Wiklund, Urban Olsson, Sven-Olof Olofsson, German Camejo
      Pages 247-254
    4. Louis Horlick
      Pages 255-261
  9. Back Matter
    Pages 263-278

About this book

Introduction

This volume contains the papers which were presented at the First Altschul Symposium, Atherosclerosis: Cellular and Molecular Interactions in the Artery Wall. The symposium was held in Saskatoon, at the University of Saskatchewan in May 1990 in memory of Dr. Rudolph Altschul, a pioneer in the field of vascular biology and the prevention of atherosclerosis. Dr. Altschul was Professor and Head of the Department of Anatomy at the University of Saskatchewan from 1955 to 1963. The challenge for biomedical scientists is to unravel the multifactorial etiology of atherosclerosis. For the last hundred and sixty years, anatomical pathologists have carefully studied the morphological changes of the human vascular wall during the initiation and evolution of the fibrofatty atherosclerotic plaque. Based on these elegant morphological observations, theories on atherogenesis were put forth by pathologists in the 1840's. Rudolf Virchow suggested that the movement of substances from the blood into the vessel wall was important for atherogenesis while Carl von Rokitansky felt that the deposition of substances on the lumenal surface of the artery resulted in the formation of atherosclerotic plaque. Since these original theories, it has become apparent that the pathogenesis of atherosclerosis is multifactorial and the disease evolves in stages. It is also likely that not all plaques arise through the same sequence of events and that many steps are involved in the development of each plaque. Today, our understanding of the complicated processes of atherogenesis is still incomplete.

Keywords

Pathogene anatomy biology development evolution memory

Editors and affiliations

  • Avrum I. Gotlieb
    • 1
  • B. Lowell Langille
    • 1
  • Sergey Fedoroff
    • 2
  1. 1.University of TorontoTorontoCanada
  2. 2.University of SaskatchewanSaskatoon, SaskatchewanCanada

Bibliographic information