Abstract
From a simple enzymatic reaction to interactions among cells, there are practically no biological events that do not have recognition of shapes as the key factor determining the uniqueness of the event. In this presentation I would like to introduce protein-linked oligosaccharides as elements carrying enormous potential information, essential for the specificity of biological events.
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R. Kornfeld & S. Kornfeld. Assembly of asparagine-linked oligosaccharides. Annu. Rev. Biochem. 54: 631 (1985).
A.J. Parodi & L.A. Quesada-Allue. Protein glycosylation in Trypahosoma cruzi. I. Characterization of dolíchol-bound monosaccharides and oligosaccharides synthesized “in vivo”. J. Biol. Chem. 257: 7637, (1982).
L.A. uuesada-Allue & A.J. Parodi. Novel mannose carrier in the trypanosomatid Crithidia fasciculata behaving as a short -saturated polyprenyl phosphate. Biochem. J. 212: 123 (1983).
J. Bischoff & R. Kornfeld. Evidence for an α -mannosidase in the endoplasmic reticulum of rat liver. J. Biol. Chem. 258: 7907 (1983).
L.J. Rizzolo & R. Kornfeld. Post-translational protein modification in the endoplasmic reticulum. Demonstration of fatty acylase and deoxymannojirimycin-sensitive α -mannosidase activities. J. Biol. Chem. 263: 9520 (1988).
S. Tronbetta, M. Bosch & A.J. Parodi. Glucosylation of glycoproteins by mammalian, plant, fungal & trypanosomatid protozoa microsomal membranes. Biochemistry 28: 8108 (1989).
A.J. Parodi. The mechanism of synthesis of the polysaccharide part of mannan in Saccharomyces cerevisiae. Arch. Blochern. Biophys. 210: 372 (1981).
S. Kornfeld. Trafficking of lysosomal enzymes in normal and disease states. J. Clin. Invest. 77: 1 (1986).
K. von Figura & A. Hasilik. Lysosomal enzymes and their receptors. Annu. Rev. Biochem. 55: 167 (1986).
L. Lang, M.L. Reitman, J. Tang, R.M. Roberts & S. Kornfeld. Lysosomal enzyme phosphorylation. Recognition of a protein-dependent determinant allows specific phosphorylation of oligosaccharides present on lysosomal enzymes. J. Biol. Chem. 259: 14663 (1984).
N.M. Dahms, P. Lobel & S. Kornfeld. Mannose 6-phosphate receptors and lysosomal enzyme targeting. J. Biol. Chem. 264: 12115 (1989).
H.J. Geuze, J.W. Slot, G.J.A.M. Strous, A. Hasilik & K. von Figura. Ultrastructural localization of the mannose 6-phosphate receptor in rat liver. J. Cell. Biol. 98: 2047 (1984).
P. Hsieh, M. Rich-Rosner & P.W. Robbins. Selective cleavage by endo- β -N-acetylglucosaminidase H at individual glycosylation sites of Sindbis virion envelope glycoprotein. J. Biol. Chem. 258: 2555 (1983).
I. Tabas & S. Kornfeld. The synthesis of complex-type oligosaccharides. III. Identification of an α-D-mannosidase activity involved in a late stage of processing of complex-type oligosaccharides. J. Biol. Chem. 253: 7779 (1978).
I. Brockhausen, E. Hull, O. Hindsgaul, H. Schachter, R.W. Shah, S.W. Michnick & J. Carver. Control of glycoprotein synthesis. Detection and characterization of a novel branching enzyme iron hen oviduct, UDP-N-acetylglucosamine:GlcNAc β 1–6 (G1cNAc β1–2) Man -R (GlcNAc to Man) β-4-N-acetylglucosaminyltransferase VI. J. Biol. Chem. 264: 11211 (1989).
M.J. Humphries, K. Matsumoto, S.L. White & K. Olden. Oligosaccharide modification by swainsonine treatment inhibits by B16–F10 murine melanoma cells. Proc. Natl. Acad. Sci. U.S.A. 83: 1752 (1986).
J.W. Dennis, S. Laferte, C. Waghorne, M.L. Kreitman & R.S. Kerbel. β 1–6 branching of Asn-linked oligosaccharides is directly associated with metastasis. Science 236: 582 (1987).
D.C. Wiley & J.J. Skehel. The structure and function of the hemagglutinin membrane glycoprotein of influenza virus. Annu. Rev. Biochem. 56: 365 (1987).
W. Weis, J.H. Brown, S. Cusack, J.C. Paulson, J.J. Skehel & D.C. Wiley. Nature 333: 426 (1988).
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© 1991 Springer Science+Business Media New York
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Parodi, A.J. (1991). N-Linked Oligosaccharide Synthesis and Cellular Sociology. In: Ceriani, R.L. (eds) Breast Epithelial Antigens. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3740-3_12
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DOI: https://doi.org/10.1007/978-1-4615-3740-3_12
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