Abstract
Several lines of evidence suggest that at least some cases of schizophrenia are a consequence of a structurally abnormal brain (Stevens, 1982). Although it is only now possible to study the cells of the brain and the genes controlling them, many of the most enduring findings in the field of schizophrenia research were established more than half a century ago and concern the timing of events. These findings include the excess of schizophrenics born in the late winter and spring (Tramer, 1929), the importance of the perinatal period in the development of psychopathology (Critchton-Browne, 1862), the association of early head trauma and psychosis (Tennent, 1937), and the earlier age of onset of schizophrenia in males (Bleuler, 1911 trans. 1950). Such findings have been widely replicated but for many years were not considered to be of fundamental importance to the understanding of schizophrenia. Instead, they were disregarded as mere chronological curiosities.
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References
Achte, K.A., Hillbrom, E. & Aalberg, V. (1969) Psychosis following war brain injuries. Acta Psychiat. Scand., 45, 1–18.
Amato, M., Howald, H., Von Muralt, G. (1987) Fetal sex distribution of peri-intraventricular haemorrhage in preterm infants. Eur. Neurol., 27(1), 20–23.
Andreasen, N. (1988) Paper presented at the 4th Biennial Winter Workshop on Schizophrenia, Badgastein.
Aylward, E., Walker, E. & Bettes, B. (1984) Intelligence in schizophrenia. Schiz. Bull., 10, 430–459.
Baron, M. & Gruen, R. (1988) Risk factors in schizophrenia: Season of birth and family history. Brit. J. Psychiat., 152, 460–465.
Barth, P.G. (1987) Disorders of neuronal migration. Can. J. Neurol. Sci., 14, 1.
Blackshaw, S. & Bowen, R.C. (1987) A case of atypical psychosis associated with alexithymia and a left fronto-temporal lesion. Can. J. Psychiat., 32, 688–692.
Bleuler, E. (1950) Dementia Praecox or the Group of Schizophrenias. New York.I.U.P.
Bradbury, T.N. & Miller, A. (1985) Season of birth in schizophrenia. Psychol. Bull., 98, 569–594.
Bruton, C. (1988) A Neuropathological Study of Temporal Lobe Epilepsy. Maudsley Monograph, O.U.P.
Castle, D., & Murray, R.M. (1990) The neurodevelopmental basis of sex differences in schizophrenia. Psychol. Med. (submitted).
Coffey, V.P. & Jessop, W.J.E. (1959) Maternal influenza and congenital deformities: A prospective study. Lancet, ii, 935–938.
Cowan, L.M., Fawcett, J.W., O’Leary, D.D. & Stanfield, B.B. (1984) Regressive events in neurogenesis. Science, 225, 1258–1265.
Critchton-Browne, J. (1862) Psychical diseases of early life. J. Mental Science, 6, 284–320.
Crow, T.J. (1980) Molecular pathology of schizophrenia: More than one disease process? Brit. Med. J., 280, 66–8.
Davison, K. & Bagley, C.R. (1969) Schizophrenia-like Psychoses Associated with Organic Disorder of the CNS. R.N. Herrington (Ed.) Current Problems in Neuropsychiatry. Headley, Kent.
Degreef, G., Mukherjee, S., Bilder, R. & Schnur, D. (1988) Season of birth and CT scan findings in schizophrenic patients. Biol. Psychiat., 24, 461–464.
Falkai, P. & Bogerts B. (1986) Cell loss in the hippocampus of schizophrenics. Eur.Arch. Psychiat. Neurol. Sci., 236, 154–161.
Feuchtwanger, E. & Mayer-Gross, W. (1938) Hirnverletzung and Schizophrene. Schweizer Archiv fur Neurologie and Psychiatrie, 41, 17–99.
Flor-Henry, P. (1978) Gender, hemispheric specialisation and psychopathology, Soc. Sci. & Med., 12b, 155.
Foerster, A., Lewis, S.W., Owen, M.J. & Murray, R.M. (1990) Premorbid adjustment and personality in psychosis: Effects of sex and diagnosis. Brit. J. Psychiat (in press).
Goodman, R. (1988) Are complications of pregnancy and birth causes of schizophrenia? Dev. Med. Child Neurol., 30, 391–406.
Goodman, R. (1989a) Neuronal misconnections and psychiatric disorder. Is there a link? Brit. J. Psychiat., 154, 292–299.
Goodman, R. (1989b) Limits to Cerebral Plasticity. In: Johnson, D.A., Utley, D.,Wyke, M. (Eds.) Children’s Head Injury: Who Cares? Falmer, Basingstoke.
Green, M.F., Satz, P., Soper, H.V. & Kharabi, F. (1987) Relationship between physical anomalies and age at onset of schizophrenia. Amer. J. Psychiat., 144,666–667.
Greenough, W.T., Black, J.E., Wallace, C.S. (1987) Experience and brain development. Child Dev., 58, 539–559.
Guy, J.D., Majorski, L.V., Wallace, C.J. & Guy, M.P. (1983) The incidence of minor physical anomalies in adult male schizophrenics. Schiz. Bull., 9, 571.
Hafner, H., Reicher, A., Maurer, K., Loffler, W., Munk-Jorgensen, P. & Stromgren, E. (1989) How does gender influence age at first hospitalisation for schizo-phrenia? A transnational case register study. Psychol. Med., 19, 903–918.
Jacob, H. & Beckman, H. (1986) Prenatal development disturbances in the limbic allocortex in schizophrenics. J. Neural. Transmiss., 65, 303–326.
Janowsky, R.T. (1972) Effects of viral infection on the developing nervous system. N. Eng. J. Med., 287, 599–604.
Janowsky, J.S. & Findlay, B.L. (1986) The outcome of perinatal brain damage. Devel. Med. Child Neurol., 28, 375–389.
Jones, P.B. & Kerwin, R.W. (1990) Left temporal lobe damage in Asperger’s syndrome. Brit. J. Psychiat., 136, 570–572.
Kendell, R.E. & Kemp, I.W. (1989) Maternal influenza in the etiology of schizophrenia. Arch. Gen. Psych., 46, 878–882.
Kinney, D.K. & Jacobsen, B. (1978) Environmental Factors in Schizophrenia. Wynne, L.C., Cromwell, R.L. & Matthysse, S. (Eds.) The Nature of Schizophrenia. p.38–51. Wiley, New York.
Kokes, R., Strauss, J.S. & Klorman, R (1977) Measuring premorbid adjustment. Schiz. Bull., 3, 186.
Kraepelin, E. (1971) Dementia Praecox and Paraphrenia. New York, Robert E. Krieger Publishing Corporation.
Kringlen, E. (1967) Heredity and Environment in the Functional Psychoses. London, William Heinemann
Kringlen, E. (1987) Contributions of Genetic Studies on Schizophrenia. Hafner, H., Gattaz, W. & Janzarik, W. (Eds.) The Search for the Causes of Schizophrenia, p.123. Springer-Verlag, Berlin.
LaFosse, J.M. & Mednick, S.A. (1990) This volume.
Lancet, (1989) Editorial: Cerebral palsy, intrapartum care and a shot in the foot. Lancet, ii, 1251–1252.
Landmesser, L. & Pilar, G. (1974) Synaptic transmission and cell death during normal ganglionic development. J. Physiol., 241, 737–749.
Lewine, R. (1981) Sex differences in schizophrenia. Psychol. Bull, 90, 432.
Lewine, R., Burbach, D. & Meltzer, H. (1984) Effects of diagnostic criteria on the ratio of male to female schizophrenic patients. Am. J. Psychiat., 141, 84.
Lewis, S.W. & Mezey, G.C. (1985) Clinical correlates of septum pellucidum cavities. Psychol. Med., 15, 43.
Lewis, S.W., Chitkara, B., Reveley, A.M. & Murray, R.M. (1987) Family history and birthweight in MZ twins concordant and discordant for psychosis. Acta Genet. Med. Gemellol., 36, 267.
Lewis, S.W., Reveley, M.A., David, A.S. & Ron, M.A. (1989) Agenesis of the corpus callosum and schizophrenia: A case report. Psychol. Med., 18, 341–347.
Lewis, M.S. (1989) Age incidence and schizophrenia, Parts I and II. Schiz. Bull.,15, 1, 59–80.
Lewis, M.S. (1990) Res ipsa Laquitor: The author replies. Schiz. Bull., 16(1), 17–28.
Loranger, A.W. (1984) Sex differences in age of onset of schizophrenia. Arch.Gen. Psychiat., 41, 157.
Lyon, M., Barr, C.E., Cannon, T.D., Mednick, S.A. & Shore, D. (1989) Fetal neural development and schizophrenia. Schiz. Bull., 15(1), 149–161.
Machon, R.A., Mednick, S.A. & Schulsinger, F. (1983) The interaction, seasonality, place of birth, genetic risk and subsequent schizophrenia in a high risk sample. Brit. J. Psychiat., 143, 383–388.
McNeill, T.F. (1987) Perinatal influences in the development of schizophrenia. In: Biological Perspectives of Schizophrenia. Helmechen & Heim (Eds.), pp. 125138. John Wiley & Sons, Ltd.
McNeill, T.F. (1988) Paper presented at the 4th Biennial Winter Workshop of Schizophrenia, Badgastein.
McNeill, T.F. & Kaij, L. (1978) Obstetric Factors in the Development of Schizophrenia. Wynne, L.C., Cromwell, R.L. & Matthysse, S. (Eds.) The Nature of Schizophrenia. p. 401, Wiley, New York.
Mednick, S.A., Machon, R.A., Huttenen, M.O. & Bonnett, D. (1988) Adult schizo-phrenia following prenatal exposure to an influenza epidemic. Arch. Gen. Psychiat., 45, 189–192.
Mosher, L.R., Pollin, W. & Stabenau, J.R. (1971) Identical twins discordant for schizophrenia. Arch. Gen. Psychiat., 24, 422.
Murray, R.M., Lewis, S.W. & Reveley, A.M. (1985) Towards an aetiological classification of schizophrenia. Lancet, i, 1023.
Murray, R.M. & Lewis, S.W. (1987) Is schizophrenia a neurodevelopmental disorder? Brit. Med. J., 295, 681–682.
Murray, R.M., Lewis, S.W., Owen, M.J., & Foerster, A. (1988) The Neurodevelop-mental Origins of Dementia Praecox. In: McGuffin, P. & Bebbington, P. (Eds.) Schizophrenia: The Major Issues. Heinemann, London.
Nelson, K.B. & Ellenberg, J.H. (1986) Antecedents of cerebral palsy: Multivariate analysis of risk. New Engl. J. Med., 315, 81–86.
Nowakowski, R.S. (1987) Basic concepts of CNS development. Child Devel., 58, 568–595.
O’Callaghan, E., Larkin, C. & Waddington, J. (1988) Clinical correlates of obstetric complications in schizophrenia. Schiz Res., 1, 125.
O’Callaghan, E., Gibson, R., Colohon, H., Walshe, D., Buckley, P.,Larkin, C. & Waddington, J.L. (1990) Season of birth effect in schizophrenia: Environmental damage or genetic morphism9 Paper presented to the 5th Biennial Workshop on Schizophrenia, Badgastein.
O’Leary, D.D. & Stanfield, B.B. (1985) Occipital cortical neurons with transient pyramidal tract axons extend and maintain collaterals to subcortical but not intracortical targets. Brain Res., 336, 326–333.
Owen, M.J., Lewis, S.W. & Murray, R.M. (1988) Obstetric complications and schizophrenia: A computed tomographic study. Psychol. Med., 18, 331–339.
Owen, M.J., Lewis, S.W., & Murray, R.M. (1989) Family history and cerebral ventricular enlargement in schizophrenia: A case control study. Brit. J. Psychiat., 154, 629–634.
Parnas, J. & Jorgensen, A. (1989) Pre-morbid psychopathology in schizophrenia spectrum. Brit. J. Psychiat., 155, 623–627.
Pearlson, G.D., Kim, W.S., Kubos, K.L., Moberg, P.J., Jayaram, G., Bascom, M.J.,Chase, G.A., Goldfinger, A.D., & Tune, L.E. (1989) Ventricle-brain ratio, computed tomographic density and brain area in 50 schizophrenics. Arch. Gen. Psychiat., 46, 690–697.
Peckham, C.S. (1978) Congenital rubella surveillance. J. Roy. Coll. Physicians, 12, 250–255.
Pollack, M., Levenstein, S. & Klein, D.F. (1968) A three year post-hospital follow up of adolescent and adult schizophrenics. Am. J. Orthopsychiat., 38, 94.
Randall, P.L. (1983) Schizophrenia, abnormal connection and brain evolution. Med.Hyothesis, 10, 247–280.
Rakic, P. (1971) Neuron-glia relationship during granule cell migration in developing cerebellar cortex: A Golgi and electron microscopic study in macacus rhesus. J. Comp. Neurol., 141, 283–312.
Reveley, A.M., & Reveley, M.A. (1983) Aqueduct stenosis and schizophrenia. J. Neurol. Neursurg. Psychiat., 46, 18.
Roberts, G.W., Colter, N., Lofthouse, R., Johnstone, E.C., Crow, T.J. (1987) Is there gliosis in schizophrenia? Investigation in the temporal lobe. Biol. Psychiat., 22, 1459–1468.
Rosanoff, A., Handy, L., Plesset, I. & Brusch, S. (1934) The etiology of so-called schizophrenic psychoses. Amer. J. Psychiat., 91, 247.
Rosenthal, D. (1962) Familial concordance by sex with respect to schizophrenia. Psychol. Bull., 59, 401.
Rosenthal, D. (1971) Genetics of Psychopathology. McGraw-Hill: New York.
Sacchetti, E., Vita, A., Battaglia, M., Calzeroni, A., Conte, T., Invernizzi, G. & Cazullo, C.L. (1987) Season of Birth and Cerebral Ventricular Enlargement in Schizophrenia. In: Cazullo et al. (eds.), Etiopathogenetic Hypothesis of Schizophrenia. MTP Press: Lancaster.
Sacchetti, E., Vita, A., Giobbio, G.M. (1989) Risk factors in schizophrenia. Brit. J. Psychiat., 155, 266–267.
Schulsinger, F., Mednick, S.A., Walker, E.F., Cudeck, R. & Moffitt, T. (1980) Biosocial implications growing from high-risk research. Acta Psychiat. Scand. Suppl., 285, 62, 112.
Schneider, G.E. (1979) Is it really better to have your brain lesioned early? Arevision of the “Kennard Principle”. Neuropsychologica, 17, 557–583.
Seeman, M.V. (1982) Gender differences in schizophrenia. Can. J. Psychiat., 27,107.
Shur, E. (1982) Season of birth in high and low genetic risk schizophrenics. Brit. J. Psychiat., 140, 410.
Silver, J., Lorenz, S., Wahlsten, S. & Coughlin, J. (1982) Axonal guidance during development of the great cerebral commisures, descriptive and experimental studies, in vivo, on the role of preformed glial pathways. J. Comp. Neurol., 210, 10–29.
Stevens, J. (1982) Neuropathology of schizophrenia. Arch. Gen. Psychiat., 39, 1131–1139.
Stevens, J. (1988) Paper presented at the 4th Biennial Winter Workshop on Schizophrenia, Badgastein.
Sunderland, R., Carpenter, R.G. & Gardner, A. (1982) Are all born equal? Brit. Med. J., 284, 624.
Taylor, D.C. (1975) Factors influencing the occurrence of schizophrenia-like psychosis in patients with TLE. Psychol. Med., 5, 249–254.
Tennent, T. (1937) Discussion on mental disorder following head injury. Proceedings of the Royal Society of Medicine, 30, 1092–1093.
Torrey, E.F. (1987) Hypotheses on the seasonality of schizophrenic births. In: Etiopathogenic Hypotheses of Schizophrenia. pp. 41–48. Lancaster: MTP Press Ltd.
Torrey, E.F., Rawlings, R. & Waldman, I.N. (1988) Schizophrenic births and viral diseases in two states. Schiz. Res., 1, 73–77.
Tramer, T. (1929) Uber die biologische Bedeutung des Geburtesmonnates fur die Psychogerkrankung. Schweizer. Archiv fur Neurologie and Psychiatrie, 24, 17–24.
Turner, S.W., Toone, B.K. & Brett-Jones, J.R. (1986) Computerised tomographic scan changes in early schizophrenia - preliminary findings. Psychol. Med., 16, 219–225.
Watson, C.G., Kucala, T., Tilleskjor, C. & Jacobs, L. (1984) Schizophrenic birth seasonality in relation to the incidence of infectious diseases. Arch. Gen. Psychiat., 41, 85–90.
Weinberger, D.R. (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiat., 44 660–669.
Wiesel, T.N. (1982) Postnatal development of the visual cortex and the influence of environment. Nature, 299, 583–591.
Wilcox, J.A. & Nasrallah, H.A. (1987) Childhood head trauma and psychosis. Psychiat. Res., 21, 303.
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Jones, P.B., Goodman, R., Owen, M.J., Lewis, S.W., Murray, R.M. (1991). Neurodevelopment and the Chronological Curiosities of Schizophrenia. In: Mednick, S.A., Cannon, T.D., Barr, C.E., LaFosse, J.M. (eds) Developmental Neuropathology of Schizophrenia. NATO ASI Series, vol 217. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3378-8_10
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