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Developmental Neuropathology of Schizophrenia

  • Sarnoff A. Mednick
  • Tyrone D. Cannon
  • Christopher E. Barr
  • José M. LaFosse

Part of the NATO ASI Series book series (NSSA, volume 217)

Table of contents

  1. Front Matter
    Pages i-viii
  2. The Developing Brain

  3. Neurochemical Aspects of the Developing Brain

  4. Neuropathological Indicants of Neurodevelopmental Anomalies in Schizophrenics

  5. Perinatal Complications in Schizophrenics

    1. Karen L. Dykes, Sarnoff A. Mednick, Tyrone D. Cannon, Christopher E. Barr
      Pages 121-140
  6. Structural Imaging and Neuropsychological Evidence of Neurodevelopmental Anomalies

  7. Facts About Schizophrenia and Neurodevelopment

    1. P. B. Jones, R. Goodman, M. J. Owen, S. W. Lewis, R. M. Murray
      Pages 191-209
    2. Jose M. LaFosse, Sarnoff A. Mednick
      Pages 211-225
  8. Back Matter
    Pages 227-247

About this book

Introduction

This volume reports the proceedings of a NATO Advanced Workshop held in Castelvecchio Pas coli, Italy, from August 28 - September 1, 1989. An important inspiration for this Workshop came from our studies in Helsinki and Denmark, which have found that exposure to an influenza epidemic during the second trimester of fetal development increases the risk of adult schizophrenia. This finding has stimulated an important new hypothesis in the study of the etiology of schizophrenia. It has suggested the possiblity that disturbances of brain development during gestation may contribute to the risk of adult schizophrenia. We determined that it would be of value to bring together schizophrenia researchers and those doing basic studies of the development of the brain. Both groups of researchers were encouraged to communicate at a level that would help other scientists to integrate their knowledge and techniques into their own discipline. For this reason, perhaps, the papers of this volume are remarkably clear and not difficult to understand. The first four chapters describe the neurochemical and structural aspects of brain development. The chapter by Dziegielewska and Saunders discusses transport mechanisms and the properties of endogenous and exogenous substances that control the internal environment of the developing brain. In the second chapter, Nowakowski reports on his studies of the develop­ ment of the hippocampus in mice genetically inbred to exhibit disruptions of neural migration.

Keywords

Neuron brain cerebral cortex cortex development dopamine magnetic resonance imaging (MRI) neuropathology schizophrenia

Editors and affiliations

  • Sarnoff A. Mednick
    • 1
  • Tyrone D. Cannon
    • 1
  • Christopher E. Barr
    • 1
  • José M. LaFosse
    • 1
  1. 1.University of Southern CaliforniaLos AngelesUSA

Bibliographic information