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Force-Frequency-Relation in Human Atrial and Ventricular Myocardium

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Cellular Function and Metabolism

Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 9))

Abstract

In human heart failure, an increase in frequency of Stimulation is followed by a reduced force of contraction in vivo and in vitro. The present study aimed to investigate whether a different origin of the myocardial sample or pretreatment with the cardioprotective agent 2, 3-butanedione-monoxime (BDM) influences the force-frequency- relationship in electrically driven muscle strips taken from failing and nonfailing human myocardium. With as well as without pretreatment with BDM, the altered force-frequency-relationship in failing compared to nonfailing human ventricular myocardium can be observed. The effectiveness and the potency to increase force of contraction following an increase in frequency of stimulation was significantly higher in atrial than in ventricular myocardium in nonfailing and failing tissue. The different observations in atrial and ventricular myocardium provide evidence for functionally relevant differences in the electromechanical coupling between the human atrial and ventricular myocardium. (Mol Cell Biochem 119: 73–78, 1993)

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Authors and Affiliations

  1. Medizinische Klinik I, Universität München, Klinikum Groβhadern, Marchioninistr. 15, D-8000, München 70, Germany

    Robert H. G. Schwinger, Michael Böhm, Andrea Koch, Rainer Uhlmann & Erland Erdmann

  2. Herzchirurgische Klinik, Universität München, Klinikum Groβhadern, Marchioninistr. 15, D-8000, München 70, Germany

    Peter Überfuhr, Eckhart Kreuzer & Bruno Reichart

Authors
  1. Robert H. G. Schwinger
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  2. Michael Böhm
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  3. Andrea Koch
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  4. Rainer Uhlmann
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  5. Peter Überfuhr
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  6. Eckhart Kreuzer
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  7. Bruno Reichart
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  8. Erland Erdmann
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Editor information

Editors and Affiliations

  1. Third Department of Internal Medicine Faculty of Medicine, University of Tokyo, Bunkyo-ku, Hongo 7-3-1, Tokyo 113, Japan

    Yoshio Yazaki (Professor of Medicine) (Professor of Medicine)

  2. Department of Internal Medicine, Jikei University School of Medicine, Katsushika-ku, Aoto 6-41-2, Tokyo 125, Japan

    Seibu Mochizuki (Professor of Medicine) (Professor of Medicine)

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© 1993 Springer Science+Business Media Dordrecht

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Schwinger, R.H.G. et al. (1993). Force-Frequency-Relation in Human Atrial and Ventricular Myocardium. In: Yazaki, Y., Mochizuki, S. (eds) Cellular Function and Metabolism. Developments in Molecular and Cellular Biochemistry, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3078-7_11

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  • DOI: https://doi.org/10.1007/978-1-4615-3078-7_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6344-6

  • Online ISBN: 978-1-4615-3078-7

  • eBook Packages: Springer Book Archive

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