Abstract
Band and Warwick showed that inbred mouse strains differed in their susceptibility to virulent strain of mouse hepatitis virus, MHV-2, and that peritoneal macrophages cultured from these mouse strains reflected their differences in susceptibility to the virus (1). Adult SJL/J mice are highly resistant to MHV-JHM and MHV-A59 (2,12,13). Our laboratory showed that membranes from the liver and intestinal epithelial cells of BALB/c mice could bind MHV-A59 virions in a solid phase assay using undenatured membrane proteins, whereas membranes from SJL/J mice did not bind virus, suggesting that differences in binding of virus to cells from different mouse strains could account for their differences in susceptibility to MHV (3). In virus-overlay protein blot assays of intestinal brush border and liver membrane proteins, MHV-A59 virions bound strongly to a 58 kDa glycoprotein from BALB/c mice, but the virus did not recognize any proteins from SJL/J mouse tissues (3,4). Anti-receptor monoclonal antibody MAb-CC1 that blocked infection of murine cell lines with MHV-A59 recognized the 110–120 kDa and 58 kDa membrane glycoproteins of BALB/c mice, but no proteins from SJL/J membranes (6,7).
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Dveksler, G.S., Basile, A.A., Cardellichio, C.B., Beauchemin, N., Dieffenbach, C.W., Holmes, K.V. (1994). Expression of MHV-A59 Receptor Glycoproteins in Susceptible and Resistant Strains of Mice. In: Laude, H., Vautherot, JF. (eds) Coronaviruses. Advances in Experimental Medicine and Biology, vol 342. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2996-5_41
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DOI: https://doi.org/10.1007/978-1-4615-2996-5_41
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