Ventilatory Response at the Onset of Exercise: An Update of the Neurohumoral Theory
There appears to be agreement on the fact that the ventilatory response at the onset of a constant-load exercise is characterized in man by two components (Dejours, 1963): a) an abrupt reflex response (“phase I”, ph 1 ventilatory response, according to the definition of Wasserman, 1978), most probably originating from the contracting muscles, whose afferent pathway is presumably represented by the group III spinal afferent fibers (Mitchell et al., 1977; Mitchell, 1990); b) a delayed response (“phase II and III”, ph2 and ph3), mainly controlled by the endogenous production of CO2. The way these components interact has been for a long time, and still is, a matter for discussion.
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