Ventilatory Response at the Onset of Exercise: An Update of the Neurohumoral Theory
There appears to be agreement on the fact that the ventilatory response at the onset of a constant-load exercise is characterized in man by two components (Dejours, 1963): a) an abrupt reflex response (“phase I”, ph 1 ventilatory response, according to the definition of Wasserman, 1978), most probably originating from the contracting muscles, whose afferent pathway is presumably represented by the group III spinal afferent fibers (Mitchell et al., 1977; Mitchell, 1990); b) a delayed response (“phase II and III”, ph2 and ph3), mainly controlled by the endogenous production of CO2. The way these components interact has been for a long time, and still is, a matter for discussion.
KeywordsWork Load Ventilatory Response Lung Transplant Recipient Typical Subject Impedance Cardiography
Unable to display preview. Download preview PDF.
- Asmussen, E., 1973. Ventilation in the transition from rest to exercise. Acta Physiol. Scand. 89:68Google Scholar
- Asmussen, E. and M. Nielsen, 1948. Studies on the initial changes in respiration in the transition from rest to work and from work to rest. Acta Physiol. Scand. 16: 270Google Scholar
- Cerretelli, P., B. Grassi, G. Ferretti, A. Colombini, M. Rieu, L. Xi, M. Meyer and C. Marconi, 1989. Regulation of ventilation at exercise after lung and heart denervation in humans. FASEB J. 3:A855 (Abstract)Google Scholar
- Dejours, P., 1963. The regulation of breathing during muscular exercise in man. A neurohumoral theory. In: “The regulation of Human Respiration”, D.J.C. Cunningham and B.B. Lloyd, ed. Blackwell, Oxford (pp. 535–547)Google Scholar
- Dill, D B., H.T. Edwards and W.V. Consolazio, 1937. Blood as a physicochemical system. XI. Man at rest. J. Biol. Chem. 118:635Google Scholar
- Meyer, M., P. Cerretelli, C. Marconi, M. Rieu and C. Cabrol, 1989. Cardiorespiratory adjustment to exercise after cardiac transplantation. In: “Clinical Aspects of O2 Transoprt and Tissue Oxygenation”, K. Reinhart and K. Eyrich, ed. Springer Verlag, Berlin, (pp. 477–499)Google Scholar
- Mitchell, J.H., 1990. Neural control of the circulation during exercise. Med. Sci. Sports Exercise 22:141Google Scholar