Abstract
Mammalian carotid bodies contain substantial amounts of norepinephrine (NE) (1,2). Despite its abundance in the chemoreceptor tissue, the role of norepinephrine in carotid body function remain uncertain. Several investigators have examined the effects of norepinephrine on carotid body activity (3–6). The reported chemoreceptor responses to NE include inhibition as well as excitation, often inhibition preceeds the excitation.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
D.M. McDonald. Peripheral chemoreceptors: Structure - function relationships of the carotid body. In: “Lung Biology in Health and Disease: The Regulation of Breathing,” Vol. 17, T.F. Hornbein, ed., Dekker, New York (1981).
S.J. Fidone and C. Gonzalez. Initiation and control of chemoreceptor activity in the carotid body. In: “Handbook of Physiology Section 3, The Respiratory System,” Vol. 2, N.S. Cherniack and T.G. Widdicombe, ed., (1986).
S.R. Sampson, MJ. Aminoff, R.A. Jaffe, and E.H. Vidruk. A pharmacological analysis of neurally induced inhibition of carotid body chemoreceptor activity in cats. J. Pharmacol. Exp. Ther 197:119 (1976).
G.E. Bisgard, R.D. Mitchell, and D.A. Herbert. Effect of dopamine, norepinephrine, and 5-hydroxytryptamine on the carotid body of the dog. Respir. Physiol. 37:61 (1979).
F. Liados and P. Zapata. Effects of adrenoceptor stimulating and blocking agents on carotid body chemosensory inhibition. J. Physiol (London) 274:501 (1978).
H.Folgering, J. Ponte, and T. Sadig. Adrenergic mechanisms and chemoreception in the carotid body of the cat and rabbit. J. Physiol (London) 325:1 1982).
D.B. Bylund and V.C. V’Prichard. Characterization of al-and a2 adrenergic receptors. Int. Rev. Neurobiol. 24:343 (1983).
Y-R. Kou, P. Ernsberger, P.A. Cragg, N.S. Cherniack, and N.R. Prabhakar. Role of ~2-adrenergic receptors in carotid body response to hypoxia. Resp. Physiol. 83:353 (1991).
N.R. Prabhakar, S.C. Landis, G.K. Kumar, D. Millikan-Kilpatrick, N.S. Cherniack, and S.E. Leeman. Substance P and neurokinin A in the cat carotid body: Localization, exogenous effects, and changes in content in response to arterial P02. Brain Res. 481:205 (1989).
S.Z. Langer and P.E. Hicks. Alpha-adrenoreceptor subtypes in blood vessels: Physiology and pharmacology. J. Cardio. Pharmacol. 6:S547 (1984).
G.E. Bisgard and M.J. Engwall. Ventilatory effects of prolonged hypoxia in goats. In: “Hypoxia. The Adaptations,in J.R. Sutton, G. Coats, and J.E. Remmers, eds., Decker Inc., Toronto (1990).
J.M. Pequignot, J.M. Cottet-Emrad, Y. Dalmaz, and L. Peyrin. Dompamine and norepinephrine dynamics in rat carotid body during long-term hypoxia. J. Auton. Nerv. Syst 21:9 (1987).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Prabhakar, N.R., Kou, YR., Cragg, P.A., Cherniack, N.S. (1993). Effect of Arterial Chemoreceptor Stimulation: Role of Norepinephrine in Hypoxic Chemotransmission. In: Data, P.G., Acker, H., Lahiri, S. (eds) Neurobiology and Cell Physiology of Chemoreception. Advances in Experimental Medicine and Biology, vol 337. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2966-8_42
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2966-8_42
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6290-6
Online ISBN: 978-1-4615-2966-8
eBook Packages: Springer Book Archive