Abstract
Recently we have shown that the density of [3H]5HT binding sites in the carotid body (CB) and within the nucleus of the tractus solitarius (NTS) of the cat is increased following unilateral chronic sectioning of the carotid sinus nerve (CSN) (Dashwood et al 1990). [125I]endothelin (ET) binding sites have also been identified in these regions, but these “receptors” are unaffected by CSN section (Spyer et al 1991). There is physiological evidence that both 5HT (Kirby and McQueen 1984) and ET (Spyer et al 1991) affect chemoreflex activity in the cat. Here we report the effect of chronic chemoreceptor stimulation, by almitrine bismesylate, on the density of central and peripheral 5HT and ET receptors in the cat.
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References
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© 1993 Springer Science+Business Media New York
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Dashwood, M.R. et al. (1993). The Effects of Almitrine on (3H)5HT and (125I) Endothelin Binding to Central and Peripheral Receptors: An in Vitro Autoradiographic Study in the Cat. In: Data, P.G., Acker, H., Lahiri, S. (eds) Neurobiology and Cell Physiology of Chemoreception. Advances in Experimental Medicine and Biology, vol 337. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2966-8_3
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DOI: https://doi.org/10.1007/978-1-4615-2966-8_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6290-6
Online ISBN: 978-1-4615-2966-8
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