Abstract
Glucose is the predominant fuel for the developing, as well as the adult brain under physiologic conditions. However, cerebral energy requirements of most mammals are quite low at birth, reflective of the immaturity of the central nervous system at this stage of development. Several studies have reported values for cerebral glucose utilization in the fetal and newborn rat brain to be 10-30% of the adult value (3-5), although it is somewhat higher in the brain stem and other structures such as the thalamus (6, 8).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aghajanian, G.K., and Bloom, F.E., The formation of synaptic junctions in developing rat brain: A quantitative electron microscopic study, Brain Res. 6:116–721, 196
Bondy, C.A., Lee, W.H., and Zhou, J., Ontogeny and cellular distribution of brain glucose transporter gene expression, Mol. and Cell. Neurosci., in press.
Cremer, J.E., Cunningham, V.J., Pardridge, W.M., Braun, L.D., and Oldendorf, W.H., Kinetics of blood-brain barrier transport of pyruvate, lactate and glucose in suckling, weanling and adult rats, J. Neurochem. 33:439–445, 1979.
Daniel, P.M., Love, E.R., and Pratt, O.E., The effect of age upon the influx of glucose into the brain, J. Physiol. 274: 141–148, 197
Dyve, S., and Gjedde, A., Glucose metabolism of fetal rat brain in utero, measured with labeled deoxyglucose, Acta.Neurol. Scand. 83: 14–19, 1991.
Nehlig, A., Pereira de Vasconcelso, A., and Boyet, S., Quantitative autoradiographic measurement of local cerebral glucose utilization of freely moving rats during postnatal development, J. Neurosci. 8: 2321–2333, 198
Pessin, J.E., and Bell, G.I., Mammalian facilitative glucose transporter family: structure and molecular regulation: in: “Annu. Rev. Physiol.” 54: 911–930, J.K. Hoffman, ed., Annual Reviews Inc., Palo Alto, CA, 1991.
Vannucci, R.C., Christensen, M.A., and Stein, D.T., Regional cerebral glucose utilization in the immature rat: Effect of hypoxia-ischemia, Ped. Res. 26: 208–214, 1989.
Nagamatsu, S., Kornhauser, J.M., Burant, CF., Seino, S., Mayo, K.E., and Bell, G.I., Glucose transporter expression in brain: cDNA sequence of mouse glut3, the brain facilitative glucose transporter isoform, and identification of sites of expression by in situ hybridization, J. Biol. Chem. 267: 467–472, 1992.
Maher, F., Vannucci, S., Takada, J., and Simpson, I.A., Expression of mouse-glut3 and human-glut3 glucose transporter proteins in brain, Biochem. Biophys. Res. Comm. 182: 703–711, 1992.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Vannucci, S.J., Willing, L.B., Vannucci, R.C. (1993). Developmental Expression of Glucose Transporters, Glut1 and Glut3, in Postnatal Rat Brain. In: Drewes, L.R., Betz, A.L. (eds) Frontiers in Cerebral Vascular Biology. Advances in Experimental Medicine and Biology, vol 331. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2920-0_1
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2920-0_1
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6267-8
Online ISBN: 978-1-4615-2920-0
eBook Packages: Springer Book Archive