Frontiers in Cerebral Vascular Biology

Transport and Its Regulation

  • Lester R. Drewes
  • A. Lorris Betz

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 331)

Table of contents

  1. Front Matter
    Pages i-x
  2. Glucose Transport

    1. Front Matter
      Pages 1-1
    2. Susan J. Vannucci, Lisa B. Willing, Robert C. Vannucci
      Pages 3-7
    3. Nancy D. Borson, Wilmar L. Salo, Lester R. Drewes
      Pages 19-24
    4. Steen Hasselbalch, Gitte Moos Knudsen, Johannes Jakobsen, Søren Holm, Olaf B. Paulson
      Pages 25-27
    5. Graeme F. Mason, Kevin L. Behar, Margaret A. Martin, Robert G. Shulman
      Pages 29-34
    6. Rolf Gruetter, Edward J. Novotny, Susan D. Boulware, Douglas L. Rothman, Graeme F. Mason, Gerald I. Shulman et al.
      Pages 35-40
  3. Electrolyte Transport

    1. Front Matter
      Pages 41-41
    2. Richard F. Keep, Jianming Xiang, A. Lorris Betz
      Pages 43-54
    3. Berislav V. Zlokovic, Liang Wang, Jasmina B. Mackic, Asma J. Saraj, J. Gordon McComb, Alicia McDonough
      Pages 55-60
    4. Hiroo Johshita, Takao Asano, Tohru Matsui, Tohru Koide
      Pages 61-64
    5. Richard F. Keep, Jianming Xiang, Steven R. Ennis, Mary E. Beer, A. Lorris Betz
      Pages 65-69
    6. Patricia A. Revest, Hazel C. Jones, N. Joan Abbott
      Pages 71-74
    7. Richard Béliveau, Lise Dallaire, Sylvie Giroux
      Pages 75-80
  4. Drug and Amino Acid Transport

    1. Front Matter
      Pages 81-81
    2. Peter Brust, Dean F. Wong, Albert Gjedde, Armin Ermisch
      Pages 95-100
    3. Kishena C. Wadhwani, Quentin R. Smith, Stanley I. Rapoport
      Pages 101-106

About this book

Introduction

During the past three decades, the cerebral vasculature and its role in blood-brain transport has been an increasingly active area of investigation and learning, particularly from an anatomical and physiological point of view. However, much less is known at the molecular and cellular level about the blood-brain barrier especially regarding the macromolecules responsible for transport, the roles played by vascular wall components (endothelial cell, pericyte, smooth muscle, basement membrane), and the mechanisms regulating brain vascular-specific protein expression and their molecular alterations during development and disease. Fundamental questions still unanswered include: What are the molecular constituents of brain endothelial cell tight junctions? What are the membrane proteins responsible for transport of specific substrates? What are the molecular signals that cause glucose transporter gene expression to be 20 to 100 times greater in brain endothelial cells in vivo than in vitro? What roles do pericytes, smooth muscle cells and basement membrane have in establishing or maintaining blood-brain transport characteristics? Are brain vascular transport systems responsible for edema following injury? Are transporter systems regulated via receptor-mediated events? Do hormones or neuromodulators regulate transporter expression? What is the molecular mechanism by which plasma proteins enter the extravascular space? Are transporters asymmetrically distributed between the luminal and abluminal endothelial cell membranes? Can prodrugs or pharmacologic agents be designed as substrate analogs and be delivered to the central nervous system via existing transporters or receptors? Can new and beneficial transporters be introduced into the brain vasculature?

Keywords

Nervous System biology brain central nervous system development gene expression muscle receptor research system

Editors and affiliations

  • Lester R. Drewes
    • 1
  • A. Lorris Betz
    • 2
  1. 1.University of MinnesotaDuluthUSA
  2. 2.The University of MichiganAnn ArborUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-2920-0
  • Copyright Information Springer-Verlag US 1993
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6267-8
  • Online ISBN 978-1-4615-2920-0
  • Series Print ISSN 0065-2598
  • About this book