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Signal Transduction from Leukocyte Integrins

  • Eric J. Brown
Chapter
Part of the Pezcoller Foundation Symposia book series (PFSO, volume 4)

Abstract

The activation of leukocytes at sites of inflamation is a topic of great meidcal importance. Leukocytes normally exist in the circulation unactivated. In response to specific inflammatory signals, they can migrate out of the bloodstream, into the site of inflammation. At the inflammatory site, they express a different phenotype than in the bloos. Neutrophils and monocytes are easily stimulated to release reactive oxygen metabolites which act both as cytocidal agents and as metabolic intermediates (Durum and Oppenheim, 1989); monocytes and macrophages are more highly phagocytic or more competent for antigen presentation (Silverstein, et al., 1989; Unanue and Allen, 1987); lymphocytes are activated to proliferate, synthesize cytokines, or perform effector functions (Durum and Oppenheim, 1989). Inhibition of leukocyte migration into, or activation at, sites of inflammation can dramatically reduce tissue damage and alter survival (Ferguson et al., 1991; Rosen, 1989; Vedder et al., 1988; Vercellotti et al., 1983). Thus, understanding the mechanisms of leukocyte exit from the bloodstream and activation at inflammatory sites is presently a subject of intense effort in several laboratories.

Keywords

Leukocyte Activation Fibronectin Receptor Neutrophil Phagocytosis Cell BioI Connective Tissue Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

DMSO

Dimethylsulfoxide;

ECM

Extracellular Matrix;

IAP

Integrin-associated 50 kD Integral Membrane Protein;

LRI

Leukocyte-response Integrin;

Mr

Relative molecular mass as estimated from SDS-PAGE;

PMN

Polymorphonuclear Neutrophil

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Copyright information

© Plenum Press, New York 1993

Authors and Affiliations

  • Eric J. Brown
    • 1
  1. 1.Departments of Medicine, Cell Biology and Physiology, and Molecular MicrobiologyWashington University School of MedicineSt. LouisUSA

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