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Cell Adhesion Molecules

Cellular Recognition Mechanisms

  • Martin E. Hemler
  • Enrico Mihich

Part of the Pezcoller Foundation Symposia book series (PFSO, volume 4)

Table of contents

  1. Front Matter
    Pages i-x
  2. Gerard Marguerie, Georges Uzan
    Pages 1-11
  3. Elisabeth N. Georges, Elizabeth L. George, Helen Rayburn, Richard O. Hynes
    Pages 29-39
  4. Martin E. Hemler, Enrico Mihich
    Pages 41-43
  5. Francisco Sánchez-Madrid, Alicia G. Arroyo, Miguel R. Campanero, Paloma Sánchez-Mateos
    Pages 45-61
  6. Martin E. Hemler, Akihide Masumoto, Bosco M. C. Chan, Paul Kassner, Joaquin Teixidó
    Pages 93-104
  7. Eric J. Brown
    Pages 105-125
  8. James B. McCarthy, Amy P. N. Skubitz, Leo T. Furcht, Elizabeth A. Wayner, Joji Iida
    Pages 127-147
  9. Maria Grazia Lampugnani, Massimo Resnati, Marco Raiteri, Marco Pittiglio, Luigi Ruco, Elisabetta Dejana
    Pages 149-163
  10. Carl G. Figdor, Yvette van Kooyk
    Pages 181-194
  11. Angela Gismondi, Fabrizio Mainiero, Gabriella Palmieri, Stefania Morrone, Michele Milella, Mario Piccoli et al.
    Pages 195-208
  12. Garth L. Nicolson, Timothy J. Yeatman, Robert J. Tressler, Timothy V. Updyke, Jun-ichi Hamada, Phillip G. Cavanaugh
    Pages 221-243
  13. Geertje La Rivière, Hans Kemperman, Mariëtte Driessens
    Pages 245-264
  14. Peter Herrlich, Wolfgang Rudy, Martin Hofmann, Robert Arch, Margot Zöller, Volker Zawadzki et al.
    Pages 265-288
  15. Back Matter
    Pages 289-294

About this book

Introduction

The Fourth Annual Pezcoller Symposium entitled Adhesion Molecules: Cellular Recognition Mechanisms was held in Rovereto, Italy, June 24-26, 1992 and was focussed on the detailed mechanisms whereby cells utilize certain integral membrane proteins to perceive their surrounding environment and interact with it. With timely presentations and stimulating discussions this Symposium addressed the genetics and biochemistry of adhesion molecules, the regulation of their functions and their role in cancer and the immune system. Emphasis was given to adhesion proteins in the integrin family because of the widespread distribution of this group of molecules and its important role in essentially all eukaryotic biological systems. The regulation of integrin genes and their expression are discussed in detail, as are specific aspects of the genetics of fibronectin. The molecular basis for the regulation of certain integrins, the function of these proteins in determining cell adhesion, and the consequences of this adhesion for the function of the cells involved are discussed. The role of certain integrins in stimulating signal transduction, the essential involvement of integrins in conditioning the function of T and NK cells function, the heterogeneity of integrins and its biological consequences, and the role of cell adhesion molecules in tumor cells invasion and metastases are all extensively analyzed. New information was presented on the role of CD44 and splice variants in normal differentiation and tumor progression.

Keywords

Activation Immune System biochemistry carcinoma genes genetics proteins proteoglycans regulation signal transduction

Editors and affiliations

  • Martin E. Hemler
    • 1
  • Enrico Mihich
    • 2
  1. 1.Dana-Farber Cancer InstituteBostonUSA
  2. 2.Roswell Park Cancer InstituteBuffaloUSA

Bibliographic information