Abstract
An extensive assortment of cell adhesion processes are mediated by receptors called integrins, a family composed of at least 20 distinct α-β heterodimers. Ligands bound by integrins include a variety of extracellular matrix molecules, cell surface Ig-like proteins, and some serum and complement proteins (Hemler, 1990; Hynes, 1992; Larson and Springer, 1990). Adhesion mediated by integrins is an essential feature of diverse processes such as tumor cell growth and metastasis, development, wound healing, and immunolocalization of leukocytes.
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Hemler, M.E., Masumoto, A., Chan, B.M.C., Kassner, P., Teixidó, J. (1993). Extracellular and Intracellular Functions of vla Proteins. In: Hemler, M.E., Mihich, E. (eds) Cell Adhesion Molecules. Pezcoller Foundation Symposia, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2830-2_7
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DOI: https://doi.org/10.1007/978-1-4615-2830-2_7
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