Abstract
Joints are often affected in Lyme disease and in some instances this may be due to immune auto-reactivity. To characterise further the immune response in this disease investigations were carried out to determine the expression of three public idiotypes on serum immunoglobulins in patients with Lyme disease during the development of varying degrees of arthritis.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Steere AC. Lyme disease. N Engl J Med (1989); 321: 586–596.
Grodzicki RL, Steere AC. Comparison of immunoblotting and indirect enzyme-linked immunosorbent assay using different antigen preparation for diagnosing early Lyme disease. J Infect Dis (1988); 157: 790–799.
Mackworth-Young CG, Harris EN, Steere AC et al. Anti-cardiolipin antibodies in Lyme disease. Arthritis Rheum (1988); 31: 1052–1056.
Shoenfeld Y, Isenberg DA, Rauch J, Madaio MP, Stollar BD, Schwartz RS. Idiotypic cross-reactions of monoclonal human lupus autoantibodies. J Exp Med (1983); 158: 718–730.
Williams W, Zumla A, Behrens R et al. Studies of a common idiotype PR4 in autoimmune rheumatic disease. Arthritis Rheum (1988); 31: 1097–1104
Watts TA, Ravirajan CT, Staines NA, Isenberg DA. A human fetal monoclonal DNA-binding antibody shares idiotypes with fetal and adult murine monoclonal DNA-binding antibodies. Immunology (1990); 69: 348–354.
Chen PP, Liu MR, Sinha S, Carson DA. A 16/6 idiotype-positive anti-DNA antibody is encoded by a conserved VH gene with no somatic mutation. Arthritis Rheum (1988); 31: 1429–1431.
Isenberg DA, Collins C. Detection of cross-reactive anti-DNA antibody idiotypes on renal tissue bound immunoglobulins from lupus patients. J Clin Invest (1985); 67: 287–294.
Beradi VP, Weeks KE, Steere AC. Serodiagnosis of early Lyme disease: analysis of IgM and IgG antibody responses by using an antibody-capture enzyme immunoassay. J Infect Dis (1988); 158: 754–760.
Long AA, Ginsberg JS, Brill-Edwards P et al. The relationship of antiphospholipid antibodies to thromboembolic disease in system lupus erythematosus: a cross sectional study. Thromb Haemost (1991); 66: 520–524.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Axford, J.S., Watts, R.A., Long, A.A., Isenberg, D.A., Steere, A.C. (1994). Expression of Public Idiotypes in Patients with Lyme Arthritis. In: Axford, J.S., Rees, D.H.E. (eds) Lyme Borreliosis. NATO ASI Series, vol 260. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2415-1_25
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2415-1_25
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6024-7
Online ISBN: 978-1-4615-2415-1
eBook Packages: Springer Book Archive