Lyme Borreliosis

  • John S. Axford
  • David H. E. Rees

Part of the NATO ASI Series book series (NSSA, volume 260)

Table of contents

  1. Front Matter
    Pages i-xi
  2. The Henry Fuller Lecture

  3. Clinical Manifestations and Treatment

    1. Gerolamo Bianchi, Laura Buffrini, Patrizia Monteforte, Vincenzo Garzia, Maria Clara Grignolo, Gian Luigi Mancardi et al.
      Pages 7-11
    2. Hans-Jürgen Christen, Folker Hanefeld, Helmut Eiffert, Reiner Thomssen
      Pages 13-20
    3. Janine Evans, Lynda Rosenfeld, Robert T. Schoen
      Pages 21-24
    4. Erol Fikrig, Fred S. Kantor, Stephen W. Barthold, Richard A. Flavell
      Pages 25-31
    5. Jana Hercogova, Marika Valesova, Marta Tomankova, Dagmar Frösslova
      Pages 33-37
    6. Marcel R. van der Linde, Harry J. G. M. Crijns
      Pages 39-44
    7. Jarmo Oksi, Inkeri Helander, Heikki Aho, Merja Marjamäki, Matti K. Viljanen
      Pages 45-48
    8. David H. E. Rees, Phillip J. Keeling, William J. McKenna, John S. Axford
      Pages 55-59
    9. Sunil K. Sood, Mark B. Salzman, Lillian Carmody, Lorry G. Rubin, Joseph Piesman
      Pages 69-73
  4. Ecology & Epidemiology

    1. Richard D. Barry, Bernard J. Hudson, Darren R. Shafren, Michelle C. Wills
      Pages 75-82
    2. Gerolamo Bianchi, Guido Rovetta
      Pages 83-88
    3. Jan Clement, Herwig Leirs, Paula McKenna, Violet Armour, David Ward, Jan Groen et al.
      Pages 89-93
    4. A. Romina Emilianus, Kathryn J. Cann, David J. M. Wright, Leonard C. Archard
      Pages 95-103
    5. B. Gilot, C. Guiguen, B. Degeilh, B. Doche, J. Pichot, J. C. Beaucournu
      Pages 105-112
    6. T. G. T. Jaenson, S. Bergström, H. A. Mejlon, L. Noppa, B. Olsén, L. Tälleklint
      Pages 113-115
    7. G. B. B. Mitchell, I. W. Smith
      Pages 117-123

About this book


Lyme Borreliosis is a worldwide infectious disease causing a multisystem illness with considerable morbidity, particularly in North America and Europe. The causative agent is the spirochaete Borrelia burgdorferi, which is usually transmitted by the ixodid tick from animal reservoirs. This book is formed by contributions from the Second European Symposium on Lyme Borreliosis, held at St George's Hospital Medical School, London in 1993, which reviewed the current state of knowledge of the condition with regard to clinical manifestations, diagnosis, treatment, ecology, epidemiology, biology and immunopathogenesis. In this book, important data is reviewed concerning the clinical manifestations of Lyme Borreliosis. It seems that strain variation of the spirochaete is the main cause of regional differences seen in the clinical presentation of patients. One striking example of this, is the relatively high incidence of Lyme arthritis in the USA and apparent rarity of this manifestion in some areas of Europe. These important studies open the way for exciting new research that focuses on the immunological and molecular mechanisms that result in disease. A full insight into the ecology of Borrelia burgdorferi is essential to a balanced understanding of the disease and a number of excellent reviews on this subject are included. Significant advances with regard to the biology of Borrelia burgdorjeri and the immunopathogenic mechanisms that result in disease have been made, enabling the role of the Band T lymphocytes in disease to be established and the development of sophisticated phenotyping methods, improved diagnostic tests and effective vaccines.


Pathogene Seen development ecology infectious infectious disease

Editors and affiliations

  • John S. Axford
    • 1
  • David H. E. Rees
    • 1
  1. 1.St. George’s Hospital Medical SchoolUniversity of LondonLondonUK

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 1994
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6024-7
  • Online ISBN 978-1-4615-2415-1
  • About this book