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Mechanosensitive Ion Channels in Vascular Endothelial Cells

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Ion Flux in Pulmonary Vascular Control

Part of the book series: NATO ASI Series ((NSSA,volume 251))

Abstract

Endothelial cells form a monolayer lining the entire vascular system and are the target of a wide variety of blood-borne substances which regulate vascular tone (reviewed by Vanhoutte, 1987). The endothelium also mediates changes in vessel tone that occur in response to mechanical forces produced by blood flowing under pressure. Both the vasodilation that occurs in response to an increase in blood flow (Rubanyi et al., 1986; Cooke et al., 1990) and the vasoconstriction that occurs in response to an increase in vascular pressure (Katusic et al., 1987; Fischeil et al., 1989) are abolished by removing the endothelium. The cellular mechanisms underlying endothelium-dependent responses to mechanical forces, however, are poorly understood.

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Author information

Authors and Affiliations

  1. Department of Physiology, University of California, San Francisco, CA, 94143-0450, USA

    Teryl R. Elam

  2. Department of Pharmacology School of Medicine, University of California, San Francisco, CA, 94143-0450, USA

    Jeffry B. Lansman

Authors
  1. Teryl R. Elam
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  2. Jeffry B. Lansman
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Editor information

Editors and Affiliations

  1. Veterans Administration Medical Center, Minneapolis, Minnesota, USA

    E. Kenneth Weir

  2. University of Nevada, Reno, Nevada, USA

    Joseph R. Hume

  3. University of Colorado, Denver, Colorado, USA

    John T. Reeves

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© 1993 Springer Science+Business Media New York

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Elam, T.R., Lansman, J.B. (1993). Mechanosensitive Ion Channels in Vascular Endothelial Cells. In: Weir, E.K., Hume, J.R., Reeves, J.T. (eds) Ion Flux in Pulmonary Vascular Control. NATO ASI Series, vol 251. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2397-0_20

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  • DOI: https://doi.org/10.1007/978-1-4615-2397-0_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6016-2

  • Online ISBN: 978-1-4615-2397-0

  • eBook Packages: Springer Book Archive

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