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Ion Flux in Pulmonary Vascular Control

  • Book
  • © 1993

Overview

Editors:
  1. E. Kenneth Weir

    1. Veterans Administration Medical Center, Minneapolis, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Joseph R. Hume

    1. University of Nevada, Reno, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. John T. Reeves

    1. University of Colorado, Denver, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: NATO Science Series A: (NSSA, volume 251)

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-ix
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  2. Pulmonary Hypertension: From Phenomenology to a Molecular Understanding of Disease Mechanisms

    1. Pulmonary Hypertension: From Phenomenology to a Molecular Understanding of Disease Mechanisms

      • Norbert F. Voelkel
      Pages 1-14

  3. The Electrophysiology of Smooth Muscle Cells and Techniques for Studying Ion Channels

    1. The Electrophysiology of Smooth Muscle Cells and Techniques for Studying Ion Channels

      • Normand Leblanc, Xiaodong Wan
      Pages 15-39

  4. Calcium Control in Smooth Muscle

    1. Calcium Channels in Arterial Smooth Muscle Cells

      • J. M. Quayle, M. T. Nelson
      Pages 41-47

    2. Interactions of Intracellular Ca2+ Pools in Vascular Smooth Muscle

      • Cornelis van Breemen, Qian Chen
      Pages 49-56

    3. Na-Ca Exchange in Isolated Coronary Myocytes: A Study Combining Voltage Clamp and Ca2+ Fluorometry

      • Gerrit Isenberg, Vladimir Ganitkevich
      Pages 57-66

    4. Role of Calcium ATPases in Pulmonary Vascular Reactivity

      • Imad S. Farrukh, John R. Michael
      Pages 67-75

    5. Fast Na+ Current and Ca2+ Currents in Smooth Muscles

      • Nicholas Sperelakis, Zhiling Xiong, Yoshihito Inoue, Yusuke Ohya, Keiichi Shimamura, David Bielefeld et al.
      Pages 77-104

    6. Influence of Physical and Environmental Factors on Ion Channels in Arterial Muscle

      • David R. Harder, Debebe Gebremedhin, Richard J. Roman
      Pages 105-110

  5. Potassium Channels in Vascular Smooth Muscle

    1. Potassium Channels Activated by Calcium Released from the Sarcoplasmic Reticulum in Vascular Smooth Muscles

      • Kenji Kitamura, Hirosi Kuriyama, Hiroyuki Nabata
      Pages 111-127

    2. ATP-Sensitive K+ Channels in the Pulmonary Vasculature

      • Lucie H. Clapp, Alison M. Gurney
      Pages 129-139

    3. Electrophysiological Actions of Extracellular ATP Application

      • C. D. Benham
      Pages 141-148

    4. An ATP-Activated Potassium Channel in Smooth Muscle Cells from the Pulmonary Artery

      • Sulayma Albarwani, Piers Nye
      Pages 149-157

    5. The Effect of Prostacyclin Analogs on Vascular K Channels

      • G. Siegel, M. Bostanjoglo, K. Rückborn, F. Schnalke, J. Mironneau, G. Stock
      Pages 159-176

  6. Potassium Channels and Oxygen Sensing

    1. Potassium Channel Modulated by Hypoxia and the Redox Status in Glomus Cells of the Carotid Body

      • Alberto R. Benot, María D. Ganfornina, José López-Barneo
      Pages 177-187

    2. Redox Regulation of K+ Channels and Hypoxic Pulmonary Vasoconstriction

      • J. M. Post, E. K. Weir, S. L. Archer, J. R. Hume
      Pages 189-204

    3. The Sodium Gradient, Potassium Channels, and Regulation of Calcium in Pulmonary and Mesenteric Arterial Smooth Muscles: Effects of Hypoxia

      • Xiao-Jian Yuan, Carmen G. Salvaterra, Mary L. Tod, Magdalena Juhaszova, William F. Goldman, Lewis J. Rubin et al.
      Pages 205-222

  7. Ion Flux in Vascular Endothelial Cells

    1. The Importance of Calcium in the Regulation of EDRF Synthesis in the Pulmonary Vasculature

      • Stephen L. Archer, Vaclav Hampl, James Huang, Nancy Cowan
      Pages 223-245

    2. The Role of Ion Channels in Vascular Endothelium

      • Andreas Lückhoff
      Pages 247-257

    3. Calcium Signalling in Vascular Endothelial Cells: Ca2+ Entry and Release

      • David J. Adams, Julius Rusko, Glen Van Slooten
      Pages 259-275
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Keywords

About this book

6 Ions can pass through a single membrane channel at a rate of 10 ions/second. Over the last decade the ability to measure ion flux so precisely and to document the opening and closing of individual ion channels has provided a powerful tool to those working on smooth muscle physiology and vascular reactivity. The use of potassium channel blockers by Tom Lloyd in the 1960s and calcium channel blockers by Ivan McMurtry in the 1970s indicated the importance of ion flux in regulating pulmonary vascular tone. Recent advances in technology. principally the patch-clamp technique and fluorescent ion-sensitive dyes. now permit a more detailed description of physiologic mechanisms. This volume arises from the Sixth Grover Conference on the Pulmonary Circulation. a NATO Advanced Research Workshop. held in Colorado in October 1992. A group of international sCientists who are leaders in the field of ion flux focused their attention on the problems of the pulmonary vasculature. The chapters in this book describe the present state of knowledge of the movement and storage of ions in vascular endothelial and smooth muscle cells. Those who are not familiar with the techniques of patch clamping and calcium imaging will find an introduction to these methods in the chapters by Leblanc and Wan and Archer et al. The role of potassium channels in oxygen sensing illustrates the rapid progress which the study of ion currents has made possible.

Editors and Affiliations

  • Veterans Administration Medical Center, Minneapolis, USA

    E. Kenneth Weir

  • University of Nevada, Reno, USA

    Joseph R. Hume

  • University of Colorado, Denver, USA

    John T. Reeves

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