Abstract
A number of recent studies suggest a role for phospholipid degradation in mitogenicsignaltransduction pathways. Particularly, the phosphodiesterase-mediated hydrolysis of phosphatidylcholine (PC) has been demonstrated in our and other laboratories to be activated in response to growth factors and oncogenes (1,2). In this regard, we have also produced evidence that activation of PLC-catalyzed hydrolysis of phosphatidylcholine (PC-PLC) is an important step in mitogenic signalling (2,3). In Xenopus laevis oocytes, microinjection of transforming ras p21 is a potent inducer of maturation, whereas microinjection of a neutralizing anti-ras p21 antibody specifically inhibits maturation induced by insulin but not by progesterone. Results from our laboratory demonstrate that microinjection of phosphatidylcholine-hydrolyzing phospholipase C (PC-PLC) is sufficient to induce maturation of Xenopus laevis oocytes (3).
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References
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© 1994 Springer Science+Business Media New York
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Moscat, J., Diaz-Meco, M.T. (1994). Phospholipid Degradation and ζPKC Activation during Mitogenic Signal Transduction. In: Municio, A.M., Miras-Portugal, M.T. (eds) Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1879-2_4
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DOI: https://doi.org/10.1007/978-1-4615-1879-2_4
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