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Endothelial Cell K+ Channels, Membrane Potential and the Release of Vasoactive Factors from the Vascular Endothelium

  • Christopher R. Triggle

Abstract

Potassium channels play an important role in the regulation of the membrane potential (E m ) of endothelial cells and thereby modulate the entry of extracellular Ca2+ (Adams, 1994; Himmel et al., 1993; Adams et al., 1989). Ca2+ entry in concert with intracellular Ca2+ release is important for the synthesis of a number of endothelium-derived vasoactive factors. Thus, the synthesis of the endothelium-derived relaxing factor (EDRF), nitric oxide (NO), and of prostacyclin (PGI2) requires, respectively, the Ca2+-calmodulin-dependent activation of the constitutive endothelial cell nitric oxide synthase (eNOS) and the Ca2+ -dependent activation of phospholipase A2 (Pollock et al., 1991; Bredt and Snyder, 1990; Carter et al., 1988; Hallam et al., 1988). Similarly, the synthesis of the vasoconstrictor peptide endothelin-1 (ET-1) requires the mobilization of intracellular Ca2+ and the activation of protein kinase C (Yanagisawa et al., 1989).

Keywords

Nitric Oxide Bovine Aorta Endothelial Cell Rabbit Thoracic Aorta EDRF Release Native Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Christopher R. Triggle
    • 1
  1. 1.Department of Pharmacology and TherapeuticsUniversity of CalgaryCalgaryCanada

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