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Diastolic Dysfuncion, Redox Stress, Extracellular Matrix Remodeling and Congestive Heart Failure in Diabetes Mellitus

  • M. R. Hayden
  • Suresh C. Tyagi
Part of the Progress in Experimental Cardiology book series (PREC, volume 9)

Summary

Congestive heart failure (CHF) is the one cardiovascular disease that has been increasing exponentially during the past decade. The current epidemic can only be expected to increase in the near future as our societies age. Hypertension (HTN), coronary artery disease (CAD), diabetes, and aging are currently the four big players and contribute to redox stress, myocellular and extramyocellular matrix (ECM) remodeling on the path to developing diastolic dysfunction (DD), systolic dysfunction (SD) and eventual CHF. The natural progression and history of CHF has a tendency to follow along two separate but interconnecting pathways as if tied together in a molecule. The roles of each of these factors will be discussed and the transition from DD to SD and overt CHF will be explored. Earlier diagnosis and compliance to current treatment paradigms by both the patient and physician are essential elements to slow or halt this progressive epidemic. Understanding the natural history of this morbid progressive disease will allow researchers and clinicians alike to develop novel treatment strategies and pave the way for newer developments in the diagnosis and treatment of CHF.

Key words

Congestive heart failure diastolic dysfunction systolic dysfunction redox stress and extracellular matrix remodeling 

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  1. 1.Department of cardiovascular atherosclerosis metabolism and aging Camdenton Community Health CenterCamdentonUSA
  2. 2.FAHA., Deppartment of Physiology and BiophysicsThe University of Mississippi Medical CenterJacksonUSA
  3. 3.Department of Family and Community MedicineUniversity of Missouri-ColumbiaUSA

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