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Spatiotemporal Focal Delivery of Dual Regenerating Factors for Osteochondral Defect Repair

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Focal Controlled Drug Delivery

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

The design of focal spatiotemporal delivery systems for multiple regeneration-inducing factors represents a crucial step in the development of effective therapies for osteochondral injuries, osteoarthritis, and other pathologies of cartilage and bone. While endogenous bone regeneration is an established process, cartilage has very limited intrinsic regeneration ability. Thus, cartilage defects progressively affect subchondral bone and alter osteochondral interface homeostasis, leading to pain and disability. Spatiotemporal delivery of osteo- and chondroinductive factors by biomaterial-based systems represents an attractive therapeutic strategy for the currently available clinical therapies that still cannot provide a superior functional replacement for the damaged or lost tissue. This chapter offers an up-to-date review of the acellular biomaterial-based strategies, aimed at simultaneous regeneration of bone and cartilage by the controlled focal delivery of the appropriate factors. It describes the various factors and delivery systems (microspheres, hydrogels, and macroporous scaffolds) developed and tested in animals and presents a novel biomaterial approach, developed by our group, for the affinity binding of TGF-β1 and BMP-4 in two separate layers, which promoted the regeneration of osteochondral interface in rabbits with osteochondral defects.

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Authors and Affiliations

  1. Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Negev, Israel

    Emil Ruvinov & Smadar Cohen

  2. The Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Negev, Israel

    Smadar Cohen

  3. The Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, Negev, Israel

    Smadar Cohen

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  1. Emil Ruvinov
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  2. Smadar Cohen
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Correspondence to Smadar Cohen .

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Editors and Affiliations

  1. School of Pharmacy-Faculty of Medicine The Hebrew University of Jerusalem, Jerusalem, Israel

    Abraham J. Domb

  2. Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Balanagar, Hyderabad, Andhra Pradesh, India

    Wahid Khan

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Ruvinov, E., Cohen, S. (2014). Spatiotemporal Focal Delivery of Dual Regenerating Factors for Osteochondral Defect Repair. In: Domb, A., Khan, W. (eds) Focal Controlled Drug Delivery. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-9434-8_22

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