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Blood Vessels in White and Brown Adipose Tissues

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Angiogenesis in Adipose Tissue

Abstract

The adipose tissue is composed of two major subtypes, white adipose tissue (WAT) and brown adipose tissue (BAT). While WAT mainly stores excess energy in, BAT plays a role in burning energy and generating heat in a process known as non-shivering thermogenesis involving uncoupling protein-1 (UCP-1). Apart from its role in energy homeostasis, adipose tissue also exerts an endocrine function secreting a number of hormones and factors. Among those are pro- and anti-angiogenic factors involved in vascular remodeling. The vasculature plays a major role in the adipose tissue and both WAT and BAT are highly vascularized.

Sharon Lim and Jennifer Honek contributed equally to this work.

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References

  • Adya R, Tan BK, Punn A, Chen J, Randeva HS. Visfatin induces human endothelial VEGF and MMP-2/9 production via MAPK and PI3K/Akt signalling pathways: novel insights into visfatin-induced angiogenesis. Cardiovasc Res. 2008;78(2):356–65. Epub 2007/12/21.

    Article  PubMed  CAS  Google Scholar 

  • Aoki S, Toda S, Sakemi T, Sugihara H. Coculture of endothelial cells and mature adipocytes actively promotes immature preadipocyte development in vitro. Cell Struct Funct. 2003;28(1):55–60. Epub 2003/03/26.

    Article  PubMed  Google Scholar 

  • Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun. 1999;257(1):79–83. Epub 1999/03/27.

    Article  PubMed  CAS  Google Scholar 

  • Arita Y, Kihara S, Ouchi N, Maeda K, Kuriyama H, Okamoto Y, et al. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation. 2002;105(24):2893–8. Epub 2002/06/19.

    Article  PubMed  CAS  Google Scholar 

  • Armulik A, Abramsson A, Betsholtz C. Endothelial/pericyte interactions. Circ Res. 2005;97(6):512–23. Epub 2005/09/17.

    Article  PubMed  CAS  Google Scholar 

  • Asano A, Morimatsu M, Nikami H, Yoshida T, Saito M. Adrenergic activation of vascular endothelial growth factor mRNA expression in rat brown adipose tissue: implication in cold-induced angiogenesis. Biochem J. 1997;328(Pt 1):179–83. Epub 1998/01/10.

    PubMed  CAS  Google Scholar 

  • Asano A, Kimura K, Saito M. Cold-induced mRNA expression of angiogenic factors in rat brown adipose tissue. J Vet Med Sci. 1999;61(4):403–9. Epub 1999/05/26.

    Article  PubMed  CAS  Google Scholar 

  • Avogaro A, de Kreutzenberg SV. Mechanisms of endothelial dysfunction in obesity. Clin Chim Acta. 2005;360(1–2):9–26. Epub 2005/06/29.

    Article  PubMed  CAS  Google Scholar 

  • Avogaro A, Albiero M, Menegazzo L, de Kreutzenberg S, Fadini GP. Endothelial dysfunction in diabetes: the role of reparatory mechanisms. Diabetes Care. 2011;34 Suppl 2:S285–90. Epub 2011/05/06.

    Article  PubMed  Google Scholar 

  • Bell LN, Cai L, Johnstone BH, Traktuev DO, March KL, Considine RV. A central role for hepatocyte growth factor in adipose tissue angiogenesis. Am J Physiol Endocrinol Metab. 2008;294(2):E336–44. Epub 2007/12/13.

    Article  PubMed  CAS  Google Scholar 

  • Bergers G, Song S. The role of pericytes in blood-vessel formation and maintenance. Neuro Oncol. 2005;7(4):452–64. Epub 2005/10/11.

    Article  PubMed  CAS  Google Scholar 

  • Bouloumie A, Drexler HC, Lafontan M, Busse R. Leptin, the product of Ob gene, promotes angiogenesis. Circ Res. 1998;83(10):1059–66. Epub 1998/11/14.

    Article  PubMed  CAS  Google Scholar 

  • Bouloumie A, Lolmede K, Sengenes C, Galitzky J, Lafontan M. Angiogenesis in adipose tissue. Ann Endocrinol (Paris). 2002;63(2 Pt 1):91–5. Epub 2002/05/08.

    CAS  Google Scholar 

  • Bozaoglu K, Curran JE, Stocker CJ, Zaibi MS, Segal D, Konstantopoulos N, et al. Chemerin, a novel adipokine in the regulation of angiogenesis. J Clin Endocrinol Metab. 2010;95(5):2476–85. Epub 2010/03/20.

    Article  PubMed  CAS  Google Scholar 

  • Brakenhielm E, Veitonmaki N, Cao R, Kihara S, Matsuzawa Y, Zhivotovsky B, et al. Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci U S A. 2004a;101(8):2476–81. Epub 2004/02/26.

    Article  PubMed  CAS  Google Scholar 

  • Brakenhielm E, Cao R, Gao B, Angelin B, Cannon B, Parini P, et al. Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice. Circ Res. 2004b;94(12):1579–88. Epub 2004/05/25.

    Article  PubMed  CAS  Google Scholar 

  • Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 1995;269(5223):546–9. Epub 1995/07/28.

    Article  PubMed  CAS  Google Scholar 

  • Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev. 2004;84(1):277–359. Epub 2004/01/13.

    Article  PubMed  CAS  Google Scholar 

  • Cao Y. Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis. Nat Rev Cancer. 2005;5(9):735–43. Epub 2005/08/05.

    Article  PubMed  CAS  Google Scholar 

  • Cao Y. Angiogenesis modulates adipogenesis and obesity. J Clin Invest. 2007;117(9):2362–8. Epub 2007/09/06.

    Article  PubMed  CAS  Google Scholar 

  • Cao Y. Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases. Nat Rev Drug Discov. 2010;9(2):107–15. Epub 2010/02/02.

    Article  PubMed  CAS  Google Scholar 

  • Chandran M, Phillips SA, Ciaraldi T, Henry RR. Adiponectin: more than just another fat cell hormone? Diabetes Care. 2003;26(8):2442–50. Epub 2003/07/29.

    Article  PubMed  CAS  Google Scholar 

  • Chen YE. Vascular cell lineage determination and differentiation. Arterioscler Thromb Vasc Biol. 2011;31(7):1467–8. Epub 2011/06/17.

    Article  PubMed  CAS  Google Scholar 

  • Cleaver O, Melton DA. Endothelial signaling during development. Nat Med. 2003;9(6):661–8. Epub 2003/06/05.

    Article  PubMed  CAS  Google Scholar 

  • Cohen B, Barkan D, Levy Y, Goldberg I, Fridman E, Kopolovic J, et al. Leptin induces angiopoietin-2 expression in adipose tissues. J Biol Chem. 2001;276(11):7697–700. Epub 2001/01/11.

    Article  PubMed  CAS  Google Scholar 

  • Coppola A, Marfella R, Coppola L, Tagliamonte E, Fontana D, Liguori E, et al. Effect of weight loss on coronary circulation and adiponectin levels in obese women. Int J Cardiol. 2009;134(3):414–6. Epub 2008/04/02.

    Article  PubMed  Google Scholar 

  • Crandall ED, Bidani A, Forster RE. Postcapillary changes in blood pH in vivo during carbonic anhydrase inhibition. J Appl Physiol. 1977;43(4):582–90. Epub 1977/10/01.

    PubMed  CAS  Google Scholar 

  • Crandall DL, Hausman GJ, Kral JG. A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives. Microcirculation. 1997;4(2):211–32. Epub 1997/06/01.

    Article  PubMed  CAS  Google Scholar 

  • Crandall DL, Groeling TM, Busler DE, Antrilli TM. Release of PAI-1 by human preadipocytes and adipocytes independent of insulin and IGF-1. Biochem Biophys Res Commun. 2000a;279(3):984–8. Epub 2001/02/13.

    Article  PubMed  CAS  Google Scholar 

  • Crandall DL, Busler DE, McHendry-Rinde B, Groeling TM, Kral JG. Autocrine regulation of human preadipocyte migration by plasminogen activator inhibitor-1. J Clin Endocrinol Metab. 2000b;85(7):2609–14. Epub 2000/07/21.

    Article  PubMed  CAS  Google Scholar 

  • Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009;360(15):1509–17. Epub 2009/04/10.

    Article  PubMed  CAS  Google Scholar 

  • Descamps B, Emanueli C. Vascular differentiation from embryonic stem cells: novel technologies and therapeutic promises. Vascul Pharmacol. 2012;56(5–6):267–79. Epub 2012/04/17.

    Article  PubMed  CAS  Google Scholar 

  • Farrington-Rock C, Crofts NJ, Doherty MJ, Ashton BA, Griffin-Jones C, Canfield AE. Chondrogenic and adipogenic potential of microvascular pericytes. Circulation. 2004;110(15):2226–32. Epub 2004/10/07.

    Article  PubMed  CAS  Google Scholar 

  • Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. 2009;15(8):930–9. Epub 2009/07/28.

    Article  PubMed  CAS  Google Scholar 

  • Fried SK, Ricci MR, Russell CD, Laferrere B. Regulation of leptin production in humans. J Nutr. 2000;130(12):3127S–31. Epub 2001/01/04.

    PubMed  CAS  Google Scholar 

  • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998;395(6704):763–70. Epub 1998/10/31.

    Article  PubMed  CAS  Google Scholar 

  • Fu Y, Luo N, Klein RL, Garvey WT. Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation. J Lipid Res. 2005;46(7):1369–79. Epub 2005/04/19.

    Article  PubMed  CAS  Google Scholar 

  • Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science. 2005;307(5708):426–30. Epub 2004/12/18.

    Article  PubMed  CAS  Google Scholar 

  • Galic S, Oakhill JS, Steinberg GR. Adipose tissue as an endocrine organ. Mol Cell Endocrinol. 2010;316(2):129–39. Epub 2009/09/03.

    Article  PubMed  CAS  Google Scholar 

  • Gerhardt H, Betsholtz C. Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res. 2003;314(1):15–23. Epub 2003/07/29.

    Article  PubMed  Google Scholar 

  • Gerstein HC, Yusuf S, Bosch J, Pogue J, Sheridan P, Dinccag N, et al. Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial. Lancet. 2006;368(9541):1096–105. Epub 2006/09/26.

    Article  PubMed  CAS  Google Scholar 

  • Gimble JM, Katz AJ, Bunnell BA. Adipose-derived stem cells for regenerative medicine. Circ Res. 2007;100(9):1249–60. Epub 2007/05/15.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein BJ, Scalia R. Adiponectin: a novel adipokine linking adipocytes and vascular function. J Clin Endocrinol Metab. 2004;89(6):2563–8. Epub 2004/06/08.

    Article  PubMed  CAS  Google Scholar 

  • Goralski KB, McCarthy TC, Hanniman EA, Zabel BA, Butcher EC, Parlee SD, et al. Chemerin, a novel adipokine that regulates adipogenesis and adipocyte metabolism. J Biol Chem. 2007;282(38):28175–88. Epub 2007/07/20.

    Article  PubMed  CAS  Google Scholar 

  • Halaas JL, Friedman JM. Leptin and its receptor. J Endocrinol. 1997;155(2):215–6. Epub 1998/01/01.

    Article  PubMed  CAS  Google Scholar 

  • Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science. 1995;269(5223):543–6. Epub 1995/07/28.

    Article  PubMed  CAS  Google Scholar 

  • Hausman GJ, Richardson RL. Adipose tissue angiogenesis. J Anim Sci. 2004;82(3):925–34. Epub 2004/03/23.

    PubMed  CAS  Google Scholar 

  • Hausman GJ, Wright JT, Richardson RL. The influence of extracellular matrix substrata on preadipocyte development in serum-free cultures of stromal-vascular cells. J Anim Sci. 1996;74(9):2117–28. Epub 1996/09/01.

    PubMed  CAS  Google Scholar 

  • Havel PJ, Kasim-Karakas S, Mueller W, Johnson PR, Gingerich RL, Stern JS. Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss. J Clin Endocrinol Metab. 1996;81(12):4406–13. Epub 1996/12/01.

    Article  PubMed  CAS  Google Scholar 

  • Himms-Hagen J, Cui J, Danforth Jr E, Taatjes DJ, Lang SS, Waters BL, et al. Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats. Am J Physiol. 1994;266(4 Pt 2):R1371–82. Epub 1994/04/11.

    PubMed  CAS  Google Scholar 

  • Hotamisligil GS. The irresistible biology of resistin. J Clin Invest. 2003;111(2):173–4. Epub 2003/01/18.

    PubMed  CAS  Google Scholar 

  • Howe R, Rao BS, Holloway BR, Stribling D. Selective beta 3-adrenergic agonists of brown adipose tissue and thermogenesis. 1. [4-[2-[(2-Hydroxy-3-phenoxypropyl)amino]ethoxy]phenoxy]acetates. J Med Chem. 1992;35(10):1751–9.

    Article  PubMed  CAS  Google Scholar 

  • Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem. 1996;271(18):10697–703. Epub 1996/05/03.

    Article  PubMed  CAS  Google Scholar 

  • Hutley LJ, Herington AC, Shurety W, Cheung C, Vesey DA, Cameron DP, et al. Human adipose tissue endothelial cells promote preadipocyte proliferation. Am J Physiol Endocrinol Metab. 2001;281(5):E1037–44. Epub 2001/10/12.

    PubMed  CAS  Google Scholar 

  • Hutley L, Shurety W, Newell F, McGeary R, Pelton N, Grant J, et al. Fibroblast growth factor 1: a key regulator of human adipogenesis. Diabetes. 2004;53(12):3097–106. Epub 2004/11/25.

    Article  PubMed  CAS  Google Scholar 

  • Jamaluddin MS, Weakley SM, Yao Q, Chen C. Resistin: functional roles and therapeutic considerations for cardiovascular disease. Br J Pharmacol. 2012;165(3):622–32. Epub 2011/05/07.

    Article  PubMed  CAS  Google Scholar 

  • Jansson PA. Endothelial dysfunction in insulin resistance and type 2 diabetes. J Intern Med. 2007;262(2):173–83. Epub 2007/07/25.

    Article  PubMed  CAS  Google Scholar 

  • Joshi PV, Lele VR. Unexpected visitor on FDG PET/CT–brown adipose tissue (BAT) in mesentery in a case of retroperitoneal extra-adrenal pheochromocytoma: is the BAT activation secondary to catecholamine-secreting pheochromocytoma? Clin Nucl Med. 2012;37(5):e119–20. Epub 2012/04/06.

    Article  PubMed  Google Scholar 

  • Kennedy GC. The role of depot fat in the hypothalamic control of food intake in the rat. Proc R Soc Lond B Biol Sci. 1953;140(901):578–96. Epub 1953/01/15.

    Article  PubMed  CAS  Google Scholar 

  • Kim SR, Bae SK, Choi KS, Park SY, Jun HO, Lee JY, et al. Visfatin promotes angiogenesis by activation of extracellular signal-regulated kinase 1/2. Biochem Biophys Res Commun. 2007;357(1):150–6. Epub 2007/04/06.

    Article  PubMed  CAS  Google Scholar 

  • Kitagawa M, Era T. Differentiation of mesodermal cells from pluripotent stem cells. Int J Hematol. 2010;91(3):373–83. Epub 2010/03/13.

    Article  PubMed  Google Scholar 

  • Komarova Y, Malik AB. Regulation of endothelial permeability via paracellular and transcellular transport pathways. Annu Rev Physiol. 2010;72:463–93. Epub 2010/02/13.

    Article  PubMed  CAS  Google Scholar 

  • Lafontan M, Langin D. Lipolysis and lipid mobilization in human adipose tissue. Prog Lipid Res. 2009;48(5):275–97. Epub 2009/05/26.

    Article  PubMed  CAS  Google Scholar 

  • Li J, Zhang YP, Kirsner RS. Angiogenesis in wound repair: angiogenic growth factors and the extracellular matrix. Microsc Res Tech. 2003;60(1):107–14. Epub 2002/12/25.

    Article  PubMed  CAS  Google Scholar 

  • Lijnen HR. Angiogenesis and obesity. Cardiovasc Res. 2008;78(2):286–93. Epub 2007/11/17.

    Article  PubMed  CAS  Google Scholar 

  • Lonnqvist F, Nordfors L, Jansson M, Thorne A, Schalling M, Arner P. Leptin secretion from adipose tissue in women. Relationship to plasma levels and gene expression. J Clin Invest. 1997;99(10):2398–404. Epub 1997/05/15.

    Article  PubMed  CAS  Google Scholar 

  • MacDougald OA, Burant CF. The rapidly expanding family of adipokines. Cell Metab. 2007;6(3):159–61. Epub 2007/09/05.

    Article  PubMed  CAS  Google Scholar 

  • Matsuda M, Shimomura I, Sata M, Arita Y, Nishida M, Maeda N, et al. Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol Chem. 2002;277(40):37487–91. Epub 2002/07/26.

    Article  PubMed  CAS  Google Scholar 

  • Miano JM. Vascular smooth muscle cell differentiation. J Biomed Res. 2010;24(3):169–80.

    Article  PubMed  CAS  Google Scholar 

  • Mu H, Ohashi R, Yan S, Chai H, Yang H, Lin P, et al. Adipokine resistin promotes in vitro angiogenesis of human endothelial cells. Cardiovasc Res. 2006;70(1):146–57. Epub 2006/03/07.

    Article  PubMed  CAS  Google Scholar 

  • Nedvidkova J, Smitka K, Kopsky V, Hainer V. Adiponectin, an adipocyte-derived protein. Physiol Res. 2005;54(2):133–40. Epub 2004/11/17.

    PubMed  CAS  Google Scholar 

  • Neels JG, Thinnes T, Loskutoff DJ. Angiogenesis in an in vivo model of adipose tissue development. FASEB J. 2004;18(9):983–5. Epub 2004/04/16.

    PubMed  CAS  Google Scholar 

  • Nishimura S, Manabe I, Nagasaki M, Hosoya Y, Yamashita H, Fujita H, et al. Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes. 2007;56(6):1517–26. Epub 2007/03/29.

    Article  PubMed  CAS  Google Scholar 

  • Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15(8):914–20. Epub 2009/07/28.

    Article  PubMed  CAS  Google Scholar 

  • O’Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell. 1994;79(2):315–28. Epub 1994/10/21.

    Article  PubMed  Google Scholar 

  • O’Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell. 1997;88(2):277–85. Epub 1997/01/24.

    Article  PubMed  Google Scholar 

  • Ohashi K, Parker JL, Ouchi N, Higuchi A, Vita JA, Gokce N, et al. Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem. 2010;285(9):6153–60. Epub 2009/12/24.

    Article  PubMed  CAS  Google Scholar 

  • Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L. VEGF receptor signalling—in control of vascular function. Nat Rev Mol Cell Biol. 2006;7(5):359–71. Epub 2006/04/25.

    Article  PubMed  CAS  Google Scholar 

  • Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, et al. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem. 2004;279(2):1304–9. Epub 2003/10/15.

    Article  PubMed  CAS  Google Scholar 

  • Ouchi N, Higuchi A, Ohashi K, Oshima Y, Gokce N, Shibata R, et al. Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science. 2010;329(5990):454–7. Epub 2010/06/19.

    Article  PubMed  CAS  Google Scholar 

  • Ouellet V, Labbe SM, Blondin DP, Phoenix S, Guerin B, Haman F, et al. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J Clin Invest. 2012;122(2):545–52. Epub 2012/01/25.

    Article  PubMed  CAS  Google Scholar 

  • Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev. 2004;84(3):767–801. Epub 2004/07/23.

    Article  PubMed  CAS  Google Scholar 

  • Park HY, Kwon HM, Lim HJ, Hong BK, Lee JY, Park BE, et al. Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Exp Mol Med. 2001;33(2):95–102. Epub 2001/07/20.

    Article  PubMed  CAS  Google Scholar 

  • Patel L, Buckels AC, Kinghorn IJ, Murdock PR, Holbrook JD, Plumpton C, et al. Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators. Biochem Biophys Res Commun. 2003;300(2):472–6. Epub 2002/12/31.

    Article  PubMed  CAS  Google Scholar 

  • Planat-Benard V, Silvestre JS, Cousin B, Andre M, Nibbelink M, Tamarat R, et al. Plasticity of human adipose lineage cells toward endothelial cells: physiological and therapeutic perspectives. Circulation. 2004;109(5):656–63. Epub 2004/01/22.

    Article  PubMed  Google Scholar 

  • Qiao L, Kinney B, Schaack J, Shao J. Adiponectin inhibits lipolysis in mouse adipocytes. Diabetes. 2011;60(5):1519–27. Epub 2011/03/25.

    Article  PubMed  CAS  Google Scholar 

  • Rajala MW, Obici S, Scherer PE, Rossetti L. Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production. J Clin Invest. 2003;111(2):225–30. Epub 2003/01/18.

    PubMed  CAS  Google Scholar 

  • Ramsay TG, Rao SV, Wolverton CK. In vitro systems for the analysis of the development of adipose tissue in domestic animals. J Nutr. 1992;122(3 Suppl):806–17. Epub 1992/03/01.

    PubMed  CAS  Google Scholar 

  • Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove CJ, Bovenkerk JE, et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation. 2004;109(10):1292–8. Epub 2004/03/03.

    Article  PubMed  Google Scholar 

  • Revollo JR, Korner A, Mills KF, Satoh A, Wang T, Garten A, et al. Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab. 2007;6(5):363–75. Epub 2007/11/07.

    Article  PubMed  CAS  Google Scholar 

  • Robertson SA, Rae CJ, Graham A. Induction of angiogenesis by murine resistin: putative role of PI3-kinase and NO-dependent pathways. Regul Pept. 2009;152(1–3):41–7. Epub 2008/08/30.

    Article  PubMed  CAS  Google Scholar 

  • Roh SG, Song SH, Choi KC, Katoh K, Wittamer V, Parmentier M, et al. Chemerin—a new adipokine that modulates adipogenesis via its own receptor. Biochem Biophys Res Commun. 2007;362(4):1013–8. Epub 2007/09/05.

    Article  PubMed  CAS  Google Scholar 

  • Ronti T, Lupattelli G, Mannarino E. The endocrine function of adipose tissue: an update. Clin Endocrinol (Oxf). 2006;64(4):355–65. Epub 2006/04/06.

    CAS  Google Scholar 

  • Rosen ED, Spiegelman BM. Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol. 2000;16:145–71. Epub 2000/10/14.

    Article  PubMed  CAS  Google Scholar 

  • Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature. 2006;444(7121):847–53. Epub 2006/12/15.

    Article  PubMed  CAS  Google Scholar 

  • Rupnick MA, Panigrahy D, Zhang CY, Dallabrida SM, Lowell BB, Langer R, et al. Adipose tissue mass can be regulated through the vasculature. Proc Natl Acad Sci U S A. 2002;99(16):10730–5. Epub 2002/08/01.

    Article  PubMed  CAS  Google Scholar 

  • Saddi-Rosa P, Oliveira CS, Giuffrida FM, Reis AF. Visfatin, glucose metabolism and vascular disease: a review of evidence. Diabetol Metab Syndr. 2010;2:21. Epub 2010/03/30.

    Article  PubMed  CAS  Google Scholar 

  • Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008;454(7207):961–7. Epub 2008/08/23.

    Article  PubMed  CAS  Google Scholar 

  • Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest. 2011;121(1):96–105. Epub 2010/12/03.

    Article  PubMed  CAS  Google Scholar 

  • Silha JV, Krsek M, Sucharda P, Murphy LJ. Angiogenic factors are elevated in overweight and obese individuals. Int J Obes (Lond). 2005;29(11):1308–14. Epub 2005/06/15.

    Article  CAS  Google Scholar 

  • Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, et al. The hormone resistin links obesity to diabetes. Nature. 2001;409(6818):307–12. Epub 2001/02/24.

    Article  PubMed  CAS  Google Scholar 

  • Suganami T, Nishida J, Ogawa Y. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol. 2005;25(10):2062–8. Epub 2005/08/27.

    Article  PubMed  CAS  Google Scholar 

  • Sumpio BE, Riley JT, Dardik A. Cells in focus: endothelial cell. Int J Biochem Cell Biol. 2002;34(12):1508–12. Epub 2002/10/16.

    Article  PubMed  CAS  Google Scholar 

  • Tang W, Zeve D, Suh JM, Bosnakovski D, Kyba M, Hammer RE, et al. White fat progenitor cells reside in the adipose vasculature. Science. 2008;322(5901):583–6. Epub 2008/09/20.

    Article  PubMed  CAS  Google Scholar 

  • Trayhurn P, Beattie JH. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc. 2001;60(3):329–39. Epub 2001/10/30.

    Article  PubMed  CAS  Google Scholar 

  • Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr. 2004;92(3):347–55. Epub 2004/10/08.

    Article  PubMed  CAS  Google Scholar 

  • Tschritter O, Fritsche A, Thamer C, Haap M, Shirkavand F, Rahe S, et al. Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes. 2003;52(2):239–43. Epub 2003/01/24.

    Article  PubMed  CAS  Google Scholar 

  • Uldry M, Yang W, St-Pierre J, Lin J, Seale P, Spiegelman BM. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab. 2006;3(5):333–41. Epub 2006/05/09.

    Article  PubMed  CAS  Google Scholar 

  • Vachharajani V, Granger DN. Adipose tissue: a motor for the inflammation associated with obesity. IUBMB Life. 2009;61(4):424–30. Epub 2009/03/26.

    Article  PubMed  CAS  Google Scholar 

  • Varzaneh FE, Shillabeer G, Wong KL, Lau DC. Extracellular matrix components secreted by microvascular endothelial cells stimulate preadipocyte differentiation in vitro. Metabolism. 1994;43(7):906–12. Epub 1994/07/01.

    Article  PubMed  CAS  Google Scholar 

  • Verma S, Li SH, Wang CH, Fedak PW, Li RK, Weisel RD, et al. Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction. Circulation. 2003;108(6):736–40. Epub 2003/07/23.

    Article  PubMed  CAS  Google Scholar 

  • Viengchareun S, Zennaro MC, Pascual-Le Tallec L, Lombes M. Brown adipocytes are novel sites of expression and regulation of adiponectin and resistin. FEBS Lett. 2002;532(3):345–50. Epub 2002/12/17.

    Article  PubMed  CAS  Google Scholar 

  • Vona-Davis L, Rose DP. Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression. Endocr Relat Cancer. 2007;14(2):189–206. Epub 2007/07/20.

    Article  PubMed  CAS  Google Scholar 

  • Waki H, Tontonoz P. Endocrine functions of adipose tissue. Annu Rev Pathol. 2007;2:31–56. Epub 2007/11/28.

    Article  PubMed  CAS  Google Scholar 

  • Wang H, Chu WS, Hemphill C, Elbein SC. Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians. J Clin Endocrinol Metab. 2002;87(6):2520–4. Epub 2002/06/07.

    Article  PubMed  CAS  Google Scholar 

  • Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante Jr AW. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003;112(12):1796–808. Epub 2003/12/18.

    PubMed  CAS  Google Scholar 

  • Winer S, Chan Y, Paltser G, Truong D, Tsui H, Bahrami J, et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med. 2009;15(8):921–9. Epub 2009/07/28.

    Article  PubMed  CAS  Google Scholar 

  • Wronska A, Kmiec Z. Structural and biochemical characteristics of various white adipose tissue depots. Acta Physiol (Oxf). 2012;205(2):194–208. Epub 2012/01/10.

    Article  CAS  Google Scholar 

  • Xie H, Tang SY, Luo XH, Huang J, Cui RR, Yuan LQ, et al. Insulin-like effects of visfatin on human osteoblasts. Calcif Tissue Int. 2007;80(3):201–10. Epub 2007/03/07.

    Article  PubMed  CAS  Google Scholar 

  • Xue Y, Cao R, Nilsson D, Chen S, Westergren R, Hedlund EM, et al. FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue. Proc Natl Acad Sci U S A. 2008;105(29):10167–72. Epub 2008/07/16.

    Article  PubMed  CAS  Google Scholar 

  • Xue Y, Petrovic N, Cao R, Larsson O, Lim S, Chen S, et al. Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metab. 2009;9(1):99–109. Epub 2009/01/02.

    Article  PubMed  CAS  Google Scholar 

  • Yamashita H, Sato Y, Kizaki T, Oh S, Nagasawa J, Ohno H. Basic fibroblast growth factor (bFGF) contributes to the enlargement of brown adipose tissue during cold acclimation. Pflugers Arch. 1994;428(3–4):352–6. Epub 1994/10/01.

    Article  PubMed  CAS  Google Scholar 

  • Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001;7(8):941–6. Epub 2001/08/02.

    Article  PubMed  CAS  Google Scholar 

  • Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. Vascular-specific growth factors and blood vessel formation. Nature. 2000;407(6801):242–8. Epub 2000/09/23.

    Article  PubMed  CAS  Google Scholar 

  • Yang WS, Lee WJ, Funahashi T, Tanaka S, Matsuzawa Y, Chao CL, et al. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin. J Clin Endocrinol Metab. 2001;86(8):3815–9. Epub 2001/08/15.

    Article  PubMed  CAS  Google Scholar 

  • Zabel BA, Ohyama T, Zuniga L, Kim JY, Johnston B, Allen SJ, et al. Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands. Exp Hematol. 2006;34(8):1106–14. Epub 2006/07/26.

    Article  PubMed  CAS  Google Scholar 

  • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature. 1994;372(6505):425–32. Epub 1994/12/01.

    Article  PubMed  CAS  Google Scholar 

  • Zuk PA. Stem cell research has only just begun. Science. 2001;293(5528):211–2. Epub 2001/07/17.

    PubMed  CAS  Google Scholar 

  • Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001;7(2):211–28. Epub 2001/04/17.

    Article  PubMed  CAS  Google Scholar 

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    Authors and Affiliations

    1. Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 17177, Stockholm, Sweden

      Sharon Lim & Jennifer Honek

    2. Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institute, 17177, Stockholm, Sweden

      Yihai Cao M.D., Ph.D.

    3. Department of Medicine and Health Sciences, Linköping University, 58185, Linköping, Sweden

      Yihai Cao M.D., Ph.D.

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    1. Sharon Lim
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    Correspondence to Yihai Cao M.D., Ph.D. .

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    1. Microbiology, Tumor and Cell biology (MT, Karolinska Institutet, Stockholm, Sweden

      Yihai Cao

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    Lim, S., Honek, J., Cao, Y. (2013). Blood Vessels in White and Brown Adipose Tissues. In: Cao, Y. (eds) Angiogenesis in Adipose Tissue. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8069-3_5

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