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MSCs in Solid Tumors and Hematological Malignancies: From Basic Biology to Therapeutic Applications

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Mesenchymal Stromal Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Compelling experimental evidence has recently unveiled that the tumor microenvironment plays a crucial role in tumor progression. Importantly, bone ­marrow-derived mesenchymal stromal cells interact with tumor cells, and these interactions trigger a series of signaling responses that ultimately favor tumor progression and survival. In this chapter, we will describe how the stroma can influence tumor fate and also how we can utilize these stromal cells to deliver antitumoral therapeutic agents based on their innate tropism for tumors and injury sites.

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Authors and Affiliations

  1. Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

    Rodrigo Jacamo, Erika Spaeth, Venkata Battula & Frank Marini

  2. Section of Molecular Hematology and Therapy, Department of Leukemia and Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

    Michael Andreeff M.D., Ph.D.

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  1. Rodrigo Jacamo
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  2. Erika Spaeth
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  3. Venkata Battula
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  4. Frank Marini
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  5. Michael Andreeff M.D., Ph.D.
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Correspondence to Michael Andreeff M.D., Ph.D. .

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  1. Madison School of Medicine and Public He, Department of Medicine, Hematology/Oncol, University of Wisconsin, 1111 Highland Avenue MC2275, Madison, 53705, USA

    Peiman Hematti

  2. Princess Margaret Hospital, Cell Therapy Program, University of Toronto, University Avenue 610, Toronto, M5G 2M9, Ontario, Canada

    Armand Keating

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Jacamo, R., Spaeth, E., Battula, V., Marini, F., Andreeff, M. (2013). MSCs in Solid Tumors and Hematological Malignancies: From Basic Biology to Therapeutic Applications. In: Hematti, P., Keating, A. (eds) Mesenchymal Stromal Cells. Stem Cell Biology and Regenerative Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-5711-4_12

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