Mesenchymal Stromal Cells

Biology and Clinical Applications

  • Peiman Hematti
  • Armand Keating

Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Table of contents

  1. Front Matter
    Pages i-xxvi
  2. Basic Biology

    1. Front Matter
      Pages 1-1
    2. Peiman Hematti, Armand Keating
      Pages 3-16
    3. Paolo Bianco, Pamela G. Robey
      Pages 43-57
    4. Arnold I. Caplan
      Pages 79-90
    5. Daniel Lucas, Sandra Pinho, Paul S. Frenette
      Pages 91-106
    6. Maria Ester Bernardo, Lynne M. Ball, Franco Locatelli, Willem E. Fibbe
      Pages 107-134
    7. Krisztián Németh, Éva Mezey
      Pages 135-143
    8. Siddiraju V. Boregowda, Donald G. Phinney
      Pages 145-167
    9. Thomas P. Lozito, Rocky S. Tuan
      Pages 169-192
    10. Rodrigo Jacamo, Erika Spaeth, Venkata Battula, Frank Marini, Michael Andreeff
      Pages 209-235
    11. Bruce A. Bunnell, Christine Gagliardi, Maria Isabel Ribeiro Dias
      Pages 237-258
    12. Graça Almeida-Porada, Christopher D. Porada, Esmail D. Zanjani
      Pages 259-275
  3. From Bench to Bedside

    1. Front Matter
      Pages 277-277
    2. Sowmya Viswanathan, Elizabeth J. Read
      Pages 279-315
    3. Derek J. Hei, David H. McKenna Jr.
      Pages 317-341
    4. Adrian P. Gee
      Pages 343-354

About this book


Mesenchymal Stromal Cell (MSC) biology has been studied for more than 4 decades and the cells have been investigated for potential clinical applications for more than 15 years. Progress has become exponential over the past decade due mainly to the broad therapeutic potential of these cells.   However, MSC studies have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs.  This cutting edge book is the ideal resource for scientists and clinicians interested in pursuing an important and rapidly developing field of research that will eventually help patients and address urgent unmet medical needs.

Features include:

  • Coverage of the biology of MSCs, latest understanding of  mechanisms of action, and role in tissue homeostasis and regeneration
  • Identifying the potential of MSCs in proceeding from bench to bedside from regulatory , GMP production, ethical and safety aspects
  • Critical analysis of clinical studies and the potential of MSCs to treat a wide variety of human diseases and tissues.   


Biology Cell Clinical Application Hematti Keating MSC Mesenchymal Stromal

Editors and affiliations

  • Peiman Hematti
    • 1
  • Armand Keating
    • 2
  1. 1.Madison School of Medicine and Public He, Department of Medicine, Hematology/OncolUniversity of WisconsinMadisonUSA
  2. 2.Princess Margaret Hospital, Cell Therapy ProgramUniversity of TorontoTorontoCanada

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-5710-7
  • Online ISBN 978-1-4614-5711-4
  • About this book