Abstract
Even though the gastrointestinal hormones have the rare privilege of being among the very first entries in the fascinating field of chemical messengers, they have had to sustain a hard and lengthy struggle to gain recognition as well defined chemical entities. In some cases, like gastrin, because the fact of its very existence was challenged again and again, and in others, like secretin, because its isolation and purification has taxed heavily the resourcefulness of a long series of investigators. Fortunately the battle has been won and the efforts of sixty years of research have been crowned by the wonderful achievements of Gregory and Tracy in gastrin2 and of Jorpes and Mutt with secretin3 and cholecystokinin4.
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References
Present address: Department of Chemistry, Case-Western Reserve University, Cleveland, Ohio.
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The excretion of water and bicarbonate was assayed by Dr. V. Mutt (Karolinska Institutet) and Dr. S. Engel (Squibb). Inhibition of gastric secretion and enhancement of bile flow were reported by Dr. M. I. Grossman (Veterans Administration, Los Angeles, California). The insulin releasing activity was tested by Dr. H. Elrick (San Diego, California). The inhibition of gastrointestinal motility was studied by Dr. W. Y. Chey (Temple University, Philadelphia, Pennsylvania). We wish to thank all these investigators for their contributions.
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We thank Dr. V. Mutt for these determinations.
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Ondetti, M.A., Sheehan, J.T., Bodanszky, M. (1968). Synthesis of Gastrointestinal Hormones. In: Back, N., Martini, L., Paoletti, R. (eds) Pharmacology of Hormonal Polypeptides and Proteins. Advances in Experimental Medicine and Biology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-4612-5_4
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