Pharmacology of Hormonal Polypeptides and Proteins

Proceedings of an International Symposium on the Pharmacology of Hormonal Polypeptides, held in Milan, Italy, September 14–16, 1967

  • Nathan Back
  • Luciano Martini
  • Rodolfo Paoletti

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 2)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Peptide and Protein Chemistry

    1. Iphigenia Photaki
      Pages 1-10
    2. A. Patchornik
      Pages 11-16
    3. Miguel A. Ondetti, John T. Sheehan, M. Bodanszky
      Pages 18-31
    4. L. Bernardi, G. Bosisio, R. de Castiglione, O. Goffredo
      Pages 32-34
    5. Garland R. Marshall
      Pages 48-52
  3. Posterior Pituitary Hormones

  4. Hypothalamic Neurohumoral Principles

About this book

Introduction

It can be concluded (under the specific experimental procedures em­ ployed) that:- 1) HCG labelled with 1 - 2 atoms of radioactive iodine did not differ sig­ nificantly from the unlabelled hormone; 2) The ovary alone exhibited a capacity to affix specifically HCG; 3) The amount of radioactive material in the ovary was directly proport­ ional to the quantity of labelled HCG injected; 4) When the HCG present in the circulation is bound to an antiserum to HCG, the antigen-antibody complex is not concentrated by the ovary; 5) Circulating labelled HCG decreased to 50% within 30 minutes following a single intravenous injection; 6) There are four different phases of ovarian uptake of HCG, namely:­ the first phase, when there is only an inflow from the circulation and stor­ age mainly in the follicular envelopes; the second phase, when there is a greater inflow than outflow; the third phase, when the inflow is equal to the outflow; and the fourth period, when the outflow is bigger than the in­ flow. REFERENCES 1. Lunenfeld, B. and Eshkol, A. Vitamins and Hormones (1967) 25:165 2. Eshkol, A. In: Recent Research on Gonadotropbio Hormones, eds. E. T. Bell andJ. A. Loraine, Edinburgh, Livingstone (1967), p. 202. 3. Eshkol, A. and Lunenfeld, B. Proc. Tel-Hashomer Hosp. (1967) 6:4. ACKNOWLEOOMEN'IS This work was supported in part by a grant from the Population Council, N. Y. , U. S. A. andbyGrantNo.

Keywords

antibody antigen pharmacology protein research

Editors and affiliations

  • Nathan Back
    • 1
  • Luciano Martini
    • 2
  • Rodolfo Paoletti
    • 3
  1. 1.Department of Biochemical Pharmacology, School of PharmacyState University of New YorkBuffaloUSA
  2. 2.Institute of PharmacologyUniversity of MilanMilanItaly
  3. 3.Institute of PharmacologyUniversity of CagliariCagliariItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4614-4612-5
  • Copyright Information Springer-Verlag US 1968
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4899-2726-2
  • Online ISBN 978-1-4614-4612-5
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • About this book