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Models of Complex Partial Seizures: Animal Studies

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Epilepsy

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Abstract

In the most general way, seizures can be classified as partial or generalized. Partial seizures have a regional (focal) cerebral localization, whereas generalized (tonic–clonic) seizures occur throughout the brain. Partial complex seizures are common, occurring in about one-third of epilepsy patients. Complex partial seizure activity is also quite common in laboratory rats and mice, as well as many other animals. Complex partial seizures are characterized by: impairment of consciousness, an immediately preceding event called an aura (simple partial seizure), automatisms, and usually arise from the temporal lobe, hence are also called temporal lobe ­seizures. The nature of the impairment of consciousness is variable and may range from an inability of the patient to respond to simple commands, to an inability to respond at all.

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References

  • McCandless, D.W. and FineSmith, R. (1992) Animal models of experimental seizures. In: Animal models of neurological disease II. Bolton, A., Baker, G., and Butterworth, R., eds. Humana Press, Baltimore, pp 133-150

    Google Scholar 

  • Abel, M., and McCandless, D.W. (1992) The kindling model of epilepsy. In: Animal models of neurological disease II, Bolton, A., Baker, G., and Butterworth, R., eds. Humana Press, Baltimore, pp 153-168

    Chapter  Google Scholar 

  • Goddard, G. (1967) Development of epileptic seizures through brain stimulation at low intensity. Nature 214:1020–1021

    Article  PubMed  CAS  Google Scholar 

  • Imaizumi, K., et al. (1959) The epilepsy like abnormalities in a strain of mice. Jpn. J. Pharmacol. 29:503–507

    Google Scholar 

  • Suzuki, J. (1976) Paroxysmal discharges in the electroencephalogram of the EL mouse. Experiment. 15: 336–338

    Article  Google Scholar 

  • Hochi, T., et al. (1987) Electron microscopic study of mossy fiber endings of the hippocampal formation in EL mice. Acta. Med. Okayama 41:81–84

    PubMed  CAS  Google Scholar 

  • Tober, C., et al. (1996) D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures. Euro. J. Pharm. 303:163–169

    Article  CAS  Google Scholar 

  • Depaulis, A., et al. (1997) Anxiogenic like consequences in animal models of complex partial seizures. Neurosci. And Biobehav Reviews 21:767–774

    Article  CAS  Google Scholar 

  • Raedt, R., and Boon, P. (2005) Cell therapy for neurological disorders: a comprehensive review. Acta Neurol. Belg. 105:158–170

    PubMed  Google Scholar 

  • Thom, S., et al. (2002) Cytoarchitectural abnormalities in hippocampal sclerosis. J. Neuropath Exp Neurol 61:510–519

    PubMed  Google Scholar 

  • Salmenpera, R., et al. (2001) Hippocampal and amygdala damage in partial epilepsy-a cross sectional MRI study of 241 patients. Epil Res 46:69–82

    Article  CAS  Google Scholar 

  • Cavazos, J., Golarai, G., and Sutula, T. (1991) Mossy fiber synaptic reorganization induced by kindling: time course of development, progression, and permanence. J. Neurosci. 11:2795–2803

    PubMed  CAS  Google Scholar 

  • Scharfman, H., Goodman, J., and Sollas, A. (2000) Granule like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 bpyramidal cells: functional implications of seizure induced neurogenesis. J. Neurosci. 20:6144–6158

    PubMed  CAS  Google Scholar 

  • Shetty, A., and Turner, D. (2000) Fetal hippocampal glutamate decarboxylase positive interneuron numbers in a rat model of temporal lobe epilepsy. J. Neurosci. 20:8788–8801

    PubMed  CAS  Google Scholar 

  • Zaman, V., and Shetty, A. (2001) Fetal hippocampal CA3 cell grafts transplanted to lesioned CA3 region of the adult hippocampus exhibit long term survival in a rat model of temporal lobe epilepsy. Neurobiol. Dis. 8:943–952

    Article  Google Scholar 

  • Nakatomi, H., et al. (2002) Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenators. Cell 110:429–441

    Article  PubMed  CAS  Google Scholar 

  • Englot, D., and Blumenfeld, H. (2009) Consciousness and epilepsy: why are complex partial seizures complex? Prog Brain Res 177:147–170

    Article  PubMed  Google Scholar 

  • Kraev, I., et al. (2009) Partial kindling induces neurogenesis, activates astrocytes and alters synaptic morphology in the dentate gyrus of freely moving adult rats. Neurosci. 18:254–267

    Article  Google Scholar 

  • Chuang, Y., et al. (2009) Contribution of nitric oxide, superoxide anion, and peroxynitrate to activation of mitochondrial apoptotic signaling in hippocampal CA3 subfield following experimental temporal lobe status epilepticus. Epilepsia 50:731–746

    Article  PubMed  CAS  Google Scholar 

  • Kuzniecky, R., et al. (1993) Magnetic resonance imaging in childhood intractable partial epilepsies: pathological correlations. Neurology 43:681–687

    PubMed  CAS  Google Scholar 

  • Brown, W. (1973) Structural substrate of seizure foci in the temporal lobe. In: Brazier, M., ed. Epilepsy: its phenomena in man. Acad. Press, N.Y. pp 339-374

    Google Scholar 

  • Brown, W., and Babb, T. (1987) Central pathological considerations of complex partial seizures. In: Hopkins, A., ed. Epilepsy Chapman and Hall, London pp 261-277

    Google Scholar 

  • Delgado-Escueta, A., et al. (1981) The nature of aggression during epileptic seizures. N Eng J Med 305:711–716

    Article  CAS  Google Scholar 

  • Manford, M., et al. (1992) National general practice study of epilepsy (NGPSE) : partial seizure patterns in a general population. Neurology 42:1911–1917

    PubMed  CAS  Google Scholar 

  • Sardo, P., et al. (2009)In the rat maximal dentate activation model of partial complex epilepsy, the anticonvulsant activity of levetiracetam is modulated by nitric oxide active drugs. J. Neural. Trans. 116:831–839

    Google Scholar 

  • Ferraro, G., and Sardo, P. (2009) Cholecystokinin-8 sulfate modulates the anticonvulsant efficacy of vigabatrin in an experimental model of partial complex epilepsy. Epilepsia 50:721–730

    Article  PubMed  CAS  Google Scholar 

  • Dube, C., Brewster, A., and Baram, T. (2009) Febrile seizures: mechanisms and relationship to epilepsy. Brain Dev 5:366–371

    Article  Google Scholar 

  • McCandless, D. (2010) Thiamine deficiency and associated clinical disorders. Springer, N. Y.

    Google Scholar 

  • Turski, W., et al. (1983) Cholinomimetics produce seizures and brain damage in rats. Experentia 39:1408–1411

    Article  CAS  Google Scholar 

  • Kudin, A., et al. (2002) Seizure dependent modulation of mitochondrial oxidative phosphorylation in rat hippocampus. Euro. J. Neurosci. 16:1105–1114

    Article  Google Scholar 

  • Yamamoto, H., and Tang, H. (1996) Preventive effect of melatonin against cyanide induced seizures and lipid peroxidation in mice. Neurosci. Letters207:89–92

    Article  CAS  Google Scholar 

  • Urbanska, E., et al. (1998) Mitochondrial toxin 3-nitropropionic acid evokes seizures in mice. Eur. J. Pharmacol. 369:55–58

    Article  Google Scholar 

  • Bindokas, V., et al. (1998) Changes in mitochondrial function resulting from synaptic activity in the rat hippocampal slice. J. Neurosci. 18:4570–4587

    PubMed  CAS  Google Scholar 

  • Dulla, C., et al. (2005) Adenosine and ATP link Pco2 to cortical excitability via pH. Neuron 48:1011–1023

    Article  PubMed  CAS  Google Scholar 

  • Pascual, O., et al. (2005) Astrocytic purinergic signaling coordinates synaptic networks. Science 310:113–116

    Article  PubMed  CAS  Google Scholar 

  • King, L., et al. (1967) Effects of convulsants on energy reserves in the cerebral cortex. J. Neurochem. 14:599–611

    Article  PubMed  CAS  Google Scholar 

  • Collins, R.C., Posner, J., and Plum, F. (1970) Cerebral energy metabolism during electroshock seizures in mice. Amer. J. Physiol. 218:943–950

    PubMed  CAS  Google Scholar 

  • Collins, R. C., et al. (1976) Metabolic anatomy of focal motor seizures. Arch. Neurology 33:536–542

    CAS  Google Scholar 

  • Walker, A., Johnson, H., and Kollros, J. (1945) Penicillin convulsions: the convulsant effects of penicillin applied to the cerebral cortex of monkey and man. Surg. Gynecol. Obstet. 81:692–703

    PubMed  CAS  Google Scholar 

  • Sokoloff, L., et al. (1977) The 14C deoxyglucose method for the measurement of local cerebral utilation: theory, procedure, and normal values in the conscious and anesthetized albino rat. J. Neurochem. 28:897–916

    Article  PubMed  CAS  Google Scholar 

  • Lust, W. D., et al. (1978) Changes in brain metabolites induced by convulsants or electroshock: effects of anticonvulsant agents. Molec. Pharmacol. 14:347–356

    CAS  Google Scholar 

  • McCandless, D. W., et al. (1979) Metabolite levels in brain following experimental seizures: the effects of maximal electroshock and phenytoin in cerebellar layers. J. Neurochem:32:743–753

    Google Scholar 

  • McCandless, D. W., et al. (1979) Metabolite levels in brain following experimental seizures: effects of isoniazid and sodium valproate in cerebellar and cerebral cortical layers. J. Neurochem. 32: 755–760

    Article  PubMed  CAS  Google Scholar 

  • McCandless, D. W., et al. (1986) Status epilepticus induced changes in primate cortical energy metabolism. Amer. J. Physiol. 251:C774-C779

    PubMed  CAS  Google Scholar 

  • McCandless, D. W., et al. (1979) Sparing of metabolic stress in Purkinje cells after maximal electroshock. Proc. Natl. Acad. Science 76:1482–1484

    Article  CAS  Google Scholar 

  • Passonneau, J., and Lowry, O. (1993) Enzymatic Analysis: a practical guide. Humana Press, Totowa N.J.

    Google Scholar 

  • Passonneau, J., Lust, W.D., and McCandless, D.W. (1980) Fixation and extraction of viable tissues. In: Techniques in Metabolic Research. C. Pogson, ed. Elsevier Pub. Co. pp 1–27

    Google Scholar 

  • McCandless, D.W., et al. (1987) Pentylenetetrazole induced changes in cerebral energy metabolism in Tupaia Glis. Epilepsia 28:184–189

    Article  PubMed  CAS  Google Scholar 

  • Duffy, T., Howse, D., and Plum, F (1975) Cerebral energy metabolism during status epilepticus. J. Neurochem. 24:925–934

    Article  PubMed  CAS  Google Scholar 

  • Collins, R.C., Tearse, R., and Lothman, E. (1983) Functional anatomy of limbic seizures: focal discharges from medial entorhinal cortex in rat. Brain Res. 280:25–40

    Article  PubMed  CAS  Google Scholar 

  • Lothman, E., and Collins, R.C. (1981) Kainic acid induced limbic seizures: metabolic, behavioral, electroencephalographic and neuropathological correlates. Brain Res. 218: 299–318

    Article  PubMed  CAS  Google Scholar 

  • McCandless, D. W., Mintun, M., and Collins, R. C. (1986) Comparison of 6-14C-glucose and 14C DG quantitative autoradiography. Trans. Amer. Soc. Neurochem. 17:173

    Google Scholar 

  • Dworsky, S., and McCandless, D.W. (1987) Regional cerebral energy metabolism in bicuculline induced seizures. Neurochem. Res. 12:237–240

    Article  PubMed  CAS  Google Scholar 

  • Chung, S., (2009) Lacosamide: pharmacology, action and efficacy in partial onset seizures. Expt Rev Neurother. 9:33–42

    Article  Google Scholar 

  • Ohr, T., et al. (2007) Lacosamide, a novel anti-convulsant drug shows efficacy with a wide safety margin. Epil. Res. pil. Res. 74:147–154

    Google Scholar 

  • Beyreuther, B., et al. (2007) Lacosamide: a review of preclinical properties. CNS Drug Rev, 13:21–42

    Article  PubMed  CAS  Google Scholar 

  • Parekh, M., et al. (2010) Early MR diffusion and relaxation changes in the parahippocampal gyrus precede the onset of spontaneous seizures in an animal model of chronic limbic epilepsy. Exper. Neurol. Doi:10.1016/j

    Google Scholar 

  • Lothman, E., et al. (1990) Recurrent spontaneous hippocampal seizures in the rat as a chronic sequela to limbic status epilepticus. Epil. Res. 6:110–118

    Article  CAS  Google Scholar 

  • Annegers, J., et al. (1987) Factors prognostic of unprovoked seizures after febrile convulsions. N. Eng. J. Med. 316:493–498

    Article  CAS  Google Scholar 

  • Koyama, R., and Matsuki, N. (2010) Novel etiological therapeutic strategies for neurodiseases: mechanisms and consequences of febrile seizures: lessons from animal models. J. Pharm. Sci. doi:10.1254/jphs.o9r19fm

  • Dube, C., et al. (2006) Temporal lobe epilepsy after experimental prolonged febrile seizures. Brain 129:911–922

    Article  PubMed  Google Scholar 

  • Dube, C., et al. (2005) Interleukin 1 beta contributes to the generation of experimental febrile seizures. Ann. Neurol. 57:152–155

    Article  PubMed  CAS  Google Scholar 

  • Schuchmann, S., Vanhatalo, S., and Kaila, K. (2009) Neurobiological and physiological mechanisms of fever related epileptiform syndromes. Brain Dev. 31:378–382

    Article  PubMed  Google Scholar 

  • Toth, Z., et al. (1998) Seizure induced neuronal injury: vulnerability to febrile seizures in an immature rat model. J. Neurosci. 18:4285–4294

    PubMed  CAS  Google Scholar 

  • Lemmens, E., et al. (2008) Cytognesis in the dentate gyrus after neonatal hyperthermia induced seizures: what becomes of surviving cells. Epilepsia 49:853–860

    Article  PubMed  Google Scholar 

  • Gill, D., Ramsay, S., and Tasker, R. (2010) Selective reductions in subpopulations of GABAergic neurons in a developmental rat model of epilepsy. Brain Res. Doi:10.1016j/2010.03.054

    Google Scholar 

  • Chen, J., et al. (2010) Effects of lamotrigine and topiramate on hippocampal neurogenesis in experimental temporal lobe epilepsy. Brain Res. 1313:270–282

    Article  PubMed  CAS  Google Scholar 

  • Dube, C., et al. (2000) Prolonged febrile seizures in the immature rat model enhance hippocampal excitability in limbic circuits. Nat. Med. 5:888–894

    Google Scholar 

  • Vielhaber, S., et al. (2003) Hippocampal N-acetyl aspartate levels do not mirror neuronal cell densities in creatine supplimented epileptic rats. Euro J Neurosci. 18:2292–2300

    Article  Google Scholar 

  • Suzuki, J., Nakamoto, Y., and Shinkawa, Y. (1983) Local cerebral glucose utilization in epileptic seizures of the mutant E1 mouse Brain Res 266:359–363

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. The Chicago Medical School Department of Cell Biology and Anatomy, Rosalind Franklin University, Chicago, IL, USA

    David W. McCandless

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  1. David W. McCandless
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McCandless, D.W. (2012). Models of Complex Partial Seizures: Animal Studies. In: Epilepsy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0361-6_14

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