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Detection and Characterization of Circulating ICAM-1

  • Conference paper
Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion

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Abstract

Over the past several years, the expression of intercellular adhesion molecule-1 (ICAM-1) on cells from normal and diseased tissue has been extensively studied. Almost as soon as ICAM-1 was identified, it was found to be a cell-surface adhesion molecule that was inducible in vitro with inflammatory cytokines such as IL-1, TNFα, and IFNγ on a multitude of cell types. Furthermore, ICAM-1’s expression on cells from normal and diseased tissue has been and continues to be a focus of much research from many laboratories. To date, it has been reported that there is a low constitutive expression of ICAM-1 on venule endothelial cells; however, its expression is markedly increased at inflammatory sites (1). Furthermore, there is an increased ICAM-1 expression on multiple cell types including keratinocytes in inflammatory skin lesions (2,3), transplanted liver bile duct and perivenular hepatocytes during rejection (4), and in cases of primary biliary cirrhosis (5), endothelium in the brain surrounding MS plaques and EAE lesions in man and rodent, respectively (6–12), transplanted kidney glomeruli and tubules during rejection (13), as well as lung epithelial cells following antigen provocation (14). Increased ICAM-1 is also found on melanoma cells following metastasis (15,16) and recently ICAM-1 expression has been shown to be expressed on placental macrophages and decidua during pregnancy.

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Authors
  1. Elizabeth A. Mainolfi
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  2. Steven D. Marlin
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  3. Robert Rothlein
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Editor information

Editors and Affiliations

  1. Internal Medicine and Microbiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX, 75235-8884, USA

    Peter E. Lipsky M.D. (Professor) (Professor)

  2. Cellular Adhesion/Immunology, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Box 368, Ridgefield, CT, 06877-0368, USA

    Robert Rothlein Ph.D. (Distinguished Scientist) & Takashi Kei Kishimoto Ph.D. (Senior Scientist) (Distinguished Scientist) &  (Senior Scientist)

  3. R&D Scientific and Technical Operations, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Box 368, Ridgefield, CT, 06877-0368, USA

    Ronald B. Faanes Ph.D. (Director) (Director)

  4. Department of Pediatrics Leukocyte Biology Section, Texas Children’s Hospital Clinical Care Center, Suite 1130 6621 Fannin, MC 3-3272, Houston, TX, 77030-2399, USA

    C. Wayne Smith Ph.D. (Professor) (Professor)

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© 1993 Springer-Verlag New York Inc.

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Mainolfi, E.A., Marlin, S.D., Rothlein, R. (1993). Detection and Characterization of Circulating ICAM-1. In: Lipsky, P.E., Rothlein, R., Kishimoto, T.K., Faanes, R.B., Smith, C.W. (eds) Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9266-8_31

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  • DOI: https://doi.org/10.1007/978-1-4613-9266-8_31

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-9268-2

  • Online ISBN: 978-1-4613-9266-8

  • eBook Packages: Springer Book Archive

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